casp4
Share
  • Official Full Name
  • caspase 4, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
  • Synonyms
  • Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP-4; CASP4; CASP4_HUMAN; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; OTTHUMP00000231863; OTTHUMP00000231864; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57; EC 3.4.22
Cat.#:CASP4-0424HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP4 Protein, GST-Tagged
+Inquiry
Cat.#:CASP4-26607THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP4
+Inquiry
Cat.#:CASP4-607HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP4
+Inquiry
Cat.#:CASP4-820HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP4 Protein, His-tagged
+Inquiry
Cat.#:Casp4-1864MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp4 protein, His-tagged
+Inquiry
Cat.#:CASP4-2753MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP4 Protein
+Inquiry
Cat.#:CASP4-634RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CASP4 Protein, His-tagged
+Inquiry
Cat.#:CASP4-1861CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CASP4 protein, His-tagged
+Inquiry
Cat.#:CASP4-1862CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CASP4 protein, His-tagged
+Inquiry
Cat.#:CASP4-599HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 4, Apoptosis-related Cysteine Peptidase
+Inquiry
Cat.#:CASP4-7836HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP4 293 Cell Lysate
+Inquiry
Cat.#:CASP4-7837HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP4 293 Cell Lysate
+Inquiry

Involved Pathway

CASP4 involved in several pathways and played different roles in them. We selected most pathways CASP4 participated on our site, such as Apoptosis, Caspase cascade in apoptosis, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
BAX; CAPN2; CAPN1; HIST1H1D; CASP2; AKT2L; BCL2A; MAP3K14; VIML; DAPK3
Caspase cascade in apoptosis
DIABLO; CASP4; GAS2; LMNB1; NUMA1; SATB1; PARP1; CFL2; CRADD; TOP1
Immune System
ASB10; TRIM2; EVL; KIF11; PLD4; RAPGEF3; EIF4G2A; DCTN6; PIK3AP1; SEC61B
Innate Immune System
S100B; RNF135; LAT2; BTR12; ALCAMB; MYO9B; CFHL4; KIR2DS2; KIR3DS1; BFB
NOD1/2 Signaling Pathway
CYLD; CASP4
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TXNIPA; TXNIPB; BTR22; BTR12; BTR16; NLRP3; CASP4; BTR06; PANX1; BTR18

Protein Function

CASP4 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP4 itself. We selected most functions CASP4 had, and list some proteins which have the same functions with CASP4. You can find most of the proteins on our site.
Function
Related Protein
Function NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein PSD; CASPBL; CASP5; CASP12; CASPB; CASPA; CASP4; CASP1

Interacting Protein

CASP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP4.
COPE; SNRNP200; UFL1; SMC2; GSN; SNRPA1; UMPS; PSMB1; VDAC1; CDK2; EIF2S3; SSR4; MSH6; SLC25A1; UBXN1; DCTN1; SMC1A; PSMD6; MTHFD1L