cd14
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  • Official Full Name
  • CD14 molecule
  • Background
  • The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.
  • Synonyms
  • CD14; monocyte differentiation antigen CD14; OTTHUMP00000159892; OTTHUMP00000223710; OTTHUMP00000223711; OTTHUMP00000224328; myeloid cell-specific leucine-rich glycoprotein
Cat.#:Cd14-117MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Cd14 Protein, Fc-tagged
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Cat.#:CD14-0721HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD14 Protein, GST-Tagged
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Cat.#:CD14-2109HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14 Protein, His-tagged
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Cat.#:CD14-3008HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14 Protein, MYC/DDK-tagged
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Cat.#:CD14-204HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD14, His-tagged
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Cat.#:CD14-2100HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD14 protein
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Cat.#:CD14-264HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD14 protein
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Cat.#:CD14-28HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14, His-tagged
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Cat.#:CD14-613HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14, Fc tagged
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Cat.#:CD14-789HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD14 protein, His-tagged
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Cat.#:CD14-90HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14
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Cat.#:Cd14-118MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Cd14, His-tagged
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Cat.#:Cd14-2270MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd14, His tagged
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Cat.#:Cd14-3318MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd14, Fc-His tagged
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Cat.#:Cd14-58MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Cd14 protein, His-tagged
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Cat.#:CD14-1101RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD14 Protein, His-tagged
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Cat.#:CD14-1235RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD14 Protein
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Cat.#:Cd14-7484RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd14, Fc tagged
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Cat.#:Cd14-791RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd14 protein, His & GST-tagged
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Cat.#:CD14-8847CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD14, His tagged
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Cat.#:CD14-717RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD14 Protein, His-tagged
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Cat.#:CD14-3887CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD14
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Cat.#:CD14-790PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CD14 protein, His & T7-tagged
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Cat.#:Cd14-1385MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Cluster Of Differentiation 14, His-tagged
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Cat.#:Cd14-1711MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse CD14 Antigen
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Cat.#:CD14-1604HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD14 cell lysate
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Cat.#:CD14-2581MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD14 cell lysate
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Cat.#:CD14-1469RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD14 cell lysate
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Cat.#:CD14-1169CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD14 cell lysate
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Cat.#:CDA069PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD14
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Involved Pathway

Cd14 involved in several pathways and played different roles in them. We selected most pathways Cd14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MKNK1; RPS6KA5; PPP3R2; MAPK12A; FLNC; NGF; FGF20B; FGFR1A; ECSIT; NRAS
NF-kappa B signaling pathway
MAP3K7; CCL4L1; ICAM1; ERC1; TNFRSF13C; LAT; IRAK4; IRAK1; RELB; Ccl21a
Phagosome
ABCB3L1; PIK3C3; ATP6V1A; CTSLA; HLA-A; ATP6V0CA; HBL4; THBS4A; H2-Q10; TUBA4L
Toll-like receptor signaling pathway
TLR4; MAP2K3; TOLLIP; RIPK1; IFNA14; STAT1; MAP2K1; CXCL9; MAPK14A; PIK3R1
Hematopoietic cell lineage
CD1D2; IL3; CR1; CD1E, B2M; IL11RA; IL6R; CD34; IL1A; FCER2; IL1R2
Regulation of actin cytoskeleton
ITGB8; ACTG1; WASL; ITGAM; FGF13; ITGAE; ITGA8; F2R; RAF1; SSH3
Pathogenic Escherichia coli infection
TUBB6; WAS; TUBA8; CDC42; YWHAZ; EZR; TUBA3E; TUBB7P; CDH1; ACTB
Salmonella infection
PYCARD; CD14; TLR4; IL-8; WAS; IL8L2; KLC2; IFNG; ARPC5A; PKN3
Pertussis
MAPK13; NOS2; NFKB1; C1QA; MAPK3; AMCF-II; CALM2; TNF; C1S; Casp3
Legionellosis
HSPA8; MYD88; ITGAM; IL-8; ITGB2L; CASP8; TLR4; CASP7; NFKBIA; Itgam&Itgb2
Amoebiasis
PIK3CB; CXCL8; ACTN3; SERPINB1A; ITGB2; LAMB1; RAB5B; SERPINB1C; PIK3R5; SERPINB6
Tuberculosis
IFNA16; CASP9; CAMK2G; HLA-DMA; CAMK2D; CASP8; ATP6V0D2; HLA-DOB; BAD; IFNA6
Transcriptional misregulation in cancer
LDB1; IL2RB; NFKB1; NCOR1; MEF2C; HDAC2; SS18; PTCRA; HOXA9; MMP3

Protein Function

Cd14 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd14 itself. We selected most functions Cd14 had, and list some proteins which have the same functions with Cd14. You can find most of the proteins on our site.
Function
Related Protein
Function lipopolysaccharide binding
Related Protein PSMB4; DROSHA; BPI; TLR2; CD14; HMGB1; SCARB1; BPIFA2; PTAFR; P2RX7
Function lipoteichoic acid binding
Related Protein TREM2; CD6; CD14; TLR2; LBP
Function opsonin receptor activity
Related Protein CD14
Function peptidoglycan receptor activity
Related Protein CD14; PGLYRP4; PGLYRP3; PGLYRP1; PGLYRP2
Function protein binding
Related Protein P2RX4; PTK2; IFNA2; HDAC3; ZNF625; CASP6; CD300LD; RPS11; CENPP; UBR2

Interacting Protein

Cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd14.
FSTL1; IRAK3; DIP2A; TNFRSF1B; GJB2; POLR2J; PPP3R2; ARFGAP3; PHF20L1; b4dt77_human; TAF1; PPP1R12B; BUB1B; SVIL; OASL; TAF9; ARID2

Cd14 Related Articles

Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
Troseid, M; Nestvold, TK; et al. Soluble CD14 Is Associated with Markers of Vascular Dysfunction in Bariatric Surgery Patients. METABOLIC SYNDROME AND RELATED DISORDERS 13:119-124(2015).