|Official Full Name||cadherin 5, type 2 (vascular endothelium)|
|Background||This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.|
|Synonyms||CDH5; cadherin 5, type 2 (vascular endothelium); 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adherens junctions interactions||CDH10A; CDH9; CDH24; PVRL1A; JUPA; CDH18; CDH2; JUP; CDH11; CDH6|
|Cell adhesion molecules (CAMs)||HLA-DOA; CLDNH; OCLNA; NLGN3A; NRXN2A; CLDN5; NRXN1A; CD4; JAM2A; ALCAMA|
|Cell junction organization||INADL; CLDN4; CLDN16; PLECA; CDH4; CDH5; CDH9; F11R.2; PARVB; CADM2A|
|Cell-Cell communication||KIRREL2; JUP; CDH2; SPTBN1; CD151; PARVB; CLDN4; TESK1; DCC; DSCAMA|
|Cell-cell junction organization||CLDN7; CDH18; CDH18A; CDH13; CLDN3; CLDN4; CDH5; ANG; CLDN23; CADM2B|
|Leukocyte transendothelial migration||PIK3CA; CLDN8; ITGB2; F11R; PRKCG; ACTG1; VAV2; NCF4; CLDN2; ACTB|
|Signal Transduction||QRFP; RGR; OXGR1A.3; ARHGAP31; TAX1BP3; TNKS2; AATF; ARHGEF1A; ARHGAP8; DACT1|
CDH5 has several biochemical functions, for example, beta-catenin binding, calcium ion binding, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.
|beta-catenin binding||BTRC; DACT1; PTPRJ; APC2; C; APC; SMAD3; AXIN1; SOX17; MED12L|
|calcium ion binding||TESC; STIM2; SLIT1B; PRRG4; PCDHB11; NINL; ATP2A1; ACTN3A; SLC24A5; NKD2|
|ion channel binding||KCNIP2; USP10; PKP2; CALM; ACTN4; CAV3; PRKCSH; YWHAH; CALM1; YWHAE|
|protein binding||NINJ2; IFIH1; DMC1; LAMA4; FAM133A; PTPRB; FRMPD2; SPG11; C1D; MICA|
|protein phosphatase binding||SHOC2; TRP53; DLG3; DRD1; TP53; MVP; PIK3R2; MET; CSK; ITGA1|
|receptor binding||GNPAT; LGI1; HMGCL; TNFSF12; CNPY3; INSL4; NRG4; PTK2AA; CSNK2B; AMN|
CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.
CTNNB1; PARD6A; KDR; PARD3; SHC1; Ctnnd1