cdh5
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  • Official Full Name
  • cadherin 5, type 2 (vascular endothelium)
  • Background
  • This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
  • Synonyms
  • CDH5; cadherin 5, type 2 (vascular endothelium); 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium)
Cat.#:CDH5-0991HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH5 Protein, GST-Tagged
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Cat.#:CDH5-1696HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His
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Cat.#:CDH5-31200THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CDH5
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Cat.#:CDH5-3245HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH5, Fc-His tagged
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Cat.#:CDH5-501HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH5 protein, His-tagged
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Cat.#:CDH5-6862HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH5 protein, His & T7-tagged
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Cat.#:CDH5-148MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse CDH5, Fc Chimera
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Cat.#:Cdh5-2284MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cdh5, His tagged
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Cat.#:Cdh5-364MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Cdh5 Protein, His-tagged
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Cat.#:Cdh5-6863MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh5 protein, His & T7-tagged
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Cat.#:Cdh5-6864RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdh5 protein, His & T7-tagged
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Cat.#:Cdh5-8758RTag:FC/His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cdh5, His tagged
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Cat.#:CDH5-1573RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH5 Protein
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Cat.#:CDH5-1574RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH5 Protein, hIgG1-tagged
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Cat.#:CDH5-1575RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH5 Protein, hIgG4-tagged
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Cat.#:CDH5-5800CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDH5
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Cat.#:CDH5-1182ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDH5
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Cat.#:CDH5-2213HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH5 cell lysate
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Cat.#:CDH5-2570MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CDH5 cell lysate
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Cat.#:CDH5-1201RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CDH5 cell lysate
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Involved Pathway

CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
CDH5; CDH12; CTNNA1; CADM2B; CDH11; PVRL1A; CDH4; ANG; CDH3; CDH10
Cell adhesion molecules (CAMs)
CLDNE; ITGA6B; CD8B; HLA-DOA; CLDN7; PRPSAP2; CLDN11B; CD40; ICAM2; CLDN15LB
Cell junction organization
ANG; CDH4; CDH12A; PVRL2L; CDH11; CDH2; FBLIM1; TESK1; CLDN3; RSU1
Cell-Cell communication
RSU1; CDH17; CDH2; CDH13; LIMS1; CDH24; KIRREL; CADM2B; DSCAMA; CDH7
Cell-cell junction organization
CDH3; INADL; CDH12; CTNND1; CADM2A; CADM2; CDH6; CLDN4; PVRL2L; CDH4
Leukocyte transendothelial migration
MYL9; ITGA4; PIK3CB; RHOH; MYL12A; VCAM1; CTNNA3; CXCL12; JAM2; GNAI1
S1P2 pathway
CDH5
Signal Transduction
PTPRU; OXGR1A.3; MYO7AA; MOB1BA; PENK; TAX1BP3; OR10A5; NMB; RBBP5; RBP4

Protein Function

CDH5 has several biochemical functions, for example, beta-catenin binding, calcium ion binding, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein APC; SOX9; CTNNA3; CBY1; BCL9L; DACT1; BCL9; PTPRJ; DVL3; HDAC6
Function calcium ion binding
Related Protein ALOX8; ANXA4; PCDH1G22; DGKA; CPS1; CDH11; UBE4A; CLGN; ANXA5; EHD1A
Function ion channel binding
Related Protein FKBP1A; FGF12; ACTN1; AASS; TCAP; PDE4D; SLC8A1; FHL1; ACTN3; FAM115A
Function protein binding
Related Protein RUSC1-AS1; AZIN1; TOR1AIP1; HIST1H3A; TMF1; ERO1L; PNKP; ZIC3; BAIAP2L1; RAMP3
Function protein phosphatase binding
Related Protein HSF4; PPP1R3C; Itga10&Itgb1; CSF1R; SKAP1; KCNN4; PPARG; ITPR1; MAP2K7; ANAPC7
Function receptor binding
Related Protein PLA2G1B; MSN; PARK7; EHHADH; FGF8A; NRG2A; SELPLG; WNT5B; TESPA1; FGF10B

Interacting Protein

CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.
CTNNB1; PARD6A; KDR; PARD3; SHC1; Ctnnd1