CDH5

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CDH5

Official Full Name cadherin 5, type 2 (vascular endothelium)
Background This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
Synonyms CDH5; cadherin 5, type 2 (vascular endothelium); 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Wheat Germ
    • Tag :
    • Fc Chimera
    • Fc
    • His
    • GST
    • hIgG1
    • hIgG4
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cdh5-7173M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell His
    Human CDH5-0991H Recombinant Human CDH5 Protein, GST-Tagged Wheat Germ GST
    Human CDH5-1696H Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His NSO His
    Human CDH5-2213HCL Recombinant Human CDH5 cell lysate Human Cell N/A
    Human CDH5-31200TH Recombinant Human CDH5 Wheat Germ N/A
    Human CDH5-3245H Recombinant Human CDH5, Fc-His tagged Human Cell Fc/His
    Human CDH5-501H Recombinant Human CDH5 protein, His-tagged HEK293 His
    Human CDH5-6862H Recombinant Human CDH5 protein, His & T7-tagged E.coli His/T7
    Mouse CDH5-148M Recombinant Mouse CDH5, Fc Chimera NS0 Fc Chimera
    Mouse Cdh5-2284M Recombinant Mouse Cdh5, His tagged Human Cell His
    Mouse CDH5-2570MCL Recombinant Mouse CDH5 cell lysate Human Cell N/A
    Mouse Cdh5-364M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell His
    Mouse Cdh5-6863M Recombinant Mouse Cdh5 protein, His & T7-tagged E.coli His/T7
    Rat CDH5-1201RCL Recombinant Rat CDH5 cell lysate Human Cell N/A
    Rat Cdh5-6864R Recombinant Rat Cdh5 protein, His & T7-tagged E.coli His/T7
    Rat Cdh5-8758R Recombinant Rat Cdh5, His tagged Human Cell Fc/His
    Rhesus monkey CDH5-1573R Recombinant Rhesus Monkey CDH5 Protein HEK293 N/A
    Rhesus monkey CDH5-1574R Recombinant Rhesus Monkey CDH5 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey CDH5-1575R Recombinant Rhesus Monkey CDH5 Protein, hIgG4-tagged HEK293 hIgG4
    Chicken CDH5-5800C Recombinant Chicken CDH5 Mammalian Cell His
    Zebrafish CDH5-1182Z Recombinant Zebrafish CDH5 Mammalian Cell His

    CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junctions interactions CDH10A; CDH9; CDH24; PVRL1A; JUPA; CDH18; CDH2; JUP; CDH11; CDH6
    Cell adhesion molecules (CAMs) HLA-DOA; CLDNH; OCLNA; NLGN3A; NRXN2A; CLDN5; NRXN1A; CD4; JAM2A; ALCAMA
    Cell junction organization INADL; CLDN4; CLDN16; PLECA; CDH4; CDH5; CDH9; F11R.2; PARVB; CADM2A
    Cell-Cell communication KIRREL2; JUP; CDH2; SPTBN1; CD151; PARVB; CLDN4; TESK1; DCC; DSCAMA
    Cell-cell junction organization CLDN7; CDH18; CDH18A; CDH13; CLDN3; CLDN4; CDH5; ANG; CLDN23; CADM2B
    Leukocyte transendothelial migration PIK3CA; CLDN8; ITGB2; F11R; PRKCG; ACTG1; VAV2; NCF4; CLDN2; ACTB
    S1P2 pathway CDH5
    Signal Transduction QRFP; RGR; OXGR1A.3; ARHGAP31; TAX1BP3; TNKS2; AATF; ARHGEF1A; ARHGAP8; DACT1

    CDH5 has several biochemical functions, for example, beta-catenin binding, calcium ion binding, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding BTRC; DACT1; PTPRJ; APC2; C; APC; SMAD3; AXIN1; SOX17; MED12L
    calcium ion binding TESC; STIM2; SLIT1B; PRRG4; PCDHB11; NINL; ATP2A1; ACTN3A; SLC24A5; NKD2
    ion channel binding KCNIP2; USP10; PKP2; CALM; ACTN4; CAV3; PRKCSH; YWHAH; CALM1; YWHAE
    protein binding NINJ2; IFIH1; DMC1; LAMA4; FAM133A; PTPRB; FRMPD2; SPG11; C1D; MICA
    protein phosphatase binding SHOC2; TRP53; DLG3; DRD1; TP53; MVP; PIK3R2; MET; CSK; ITGA1
    receptor binding GNPAT; LGI1; HMGCL; TNFSF12; CNPY3; INSL4; NRG4; PTK2AA; CSNK2B; AMN

    CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.

    CTNNB1; PARD6A; KDR; PARD3; SHC1; Ctnnd1

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