CES1

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CES1

Official Full Name carboxylesterase 1
Background This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Synonyms CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; human monocyte/macrophage serine esterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1);
    • Species :
    • Cynomolgus Monkey
    • Human
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CES1-748H Recombinant Human CES1 Protein, His-tagged Insect Cell His
    Human CES1-11125H Recombinant Human CES1, His-tagged E.coli His
    Human CES1-1148H Recombinant Human CES1 Protein, GST-Tagged Wheat Germ GST
    Human CES1-29351TH Recombinant Human CES1 Wheat Germ N/A
    Human CES1-3200H Recombinant Human CES1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CES1-602H Recombinant Human CES1 Protein, His-tagged E.coli His
    Human CES1-7564HCL Recombinant Human CES1 293 Cell Lysate HEK293 N/A
    Human CES1-7565HCL Recombinant Human CES1 293 Cell Lysate HEK293 N/A
    Human CES1-900H Recombinant Human CES1, His-tagged Mammalian Cell His
    Human CES1-911H Recombinant Human CES1 Protein, His-tagged HEK293 His
    Cynomolgus Monkey CES1-403C Recombinant Cynomolgus CES1 Protein, His-tagged Mammalian Cell His
    Kit-0207 Carboxylesterase 1 Activity Assay Kit N/A

    CES1 involved in several pathways and played different roles in them. We selected most pathways CES1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations GGTLC1; CYP27B1; ACSM1; BPNT1; CYP2B6; CYP2S1; GLYATL1; NCOA2; UGT1B7; ABHD14B
    Drug metabolism - other enzymes UGT2A3; UCKL1; UPB1; UGT1A7C; GUSB; UCK2; NAT2; HPRT1; UGT1A9; ITPA
    E2F transcription factor network YY1; DHFR; HIC1; E2F6; TRIM28; CES3; CEBPA; MYBL2; PRMT5; RYBP
    Fluoropyrimidine Activity DPYS; SLC22A7; UPP2; DHFR; DPYD; CES1; TYMP
    Irinotecan Pathway BCHE; ABCC2; CES1; CYP3A5
    Metabolic pathways BCMO1; INPP5L; NDUFA10; POLR2J2; SPHK1; ALDH3A2; GALNT3; TPI1B; ENPP3; IDH3G
    Metabolism UGT1B2; CTH; NUDT4B; NDUFAF3; DPEP2; CYP2K18; CYP2K22; CES1; DGUOK; ETFA
    Phase 1 - Functionalization of compounds CYP3C4; CYP2K22; CYP2U1; CYP2Y3; CYP46A1; CYP3A7; CYP2N13; CYP2R1; CYP8B2; CYP27B1

    CES1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CES1 itself. We selected most functions CES1 had, and list some proteins which have the same functions with CES1. You can find most of the proteins on our site.

    Function Related Protein
    carboxylic ester hydrolase activity NCEH1B; LYPLAL1; ACOT11; Ces2c; LIPH; ACOT12; ACOT2; ACOT9; ABHD2B; AADACL2
    methylumbelliferyl-acetate deacetylase activity CES2; CES1; ESD
    sterol esterase activity CES1D; CES3; Cel; CEL.1; CES5A; LIPA; CES1
    triglyceride lipase activity CES1; PNPLA3; Cel; LIPF; PNLIPRP2; PNLIPRP3; PNLIP; CEL.1; LIPC; CES1D

    CES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES1.

    CREB3

    Ishizuka, T; Yoshigae, Y; et al. Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1. DRUG METABOLISM AND DISPOSITION 41:1888-1895(2013).
    Zhao, B; Bie, JH; et al. Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C427-C435(2012).

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