Recombinant Human CES1 Protein, MYC/DDK-tagged
Cat.No. : | CES1-3200H |
Product Overview : | Recombinant Human CES1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
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Description : | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 60.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | CES1 carboxylesterase 1 [ Homo sapiens ] |
Official Symbol : | CES1 |
Synonyms : | ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH |
Gene ID : | 1066 |
mRNA Refseq : | NM_001025194 |
Protein Refseq : | NP_001020365 |
UniProt ID : | P23141 |
Products Types
◆ Recombinant Protein | ||
CES1-654H | Recombinant Human CES1 protein, His-tagged | +Inquiry |
CES1-602H | Recombinant Human CES1 Protein, His-tagged | +Inquiry |
CES1-151C | Recombinant Cynomolgus Monkey CES1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CES1-901H | Recombinant Human CES1, His-tagged | +Inquiry |
CES1-13H | Active Recombinant Human CES1 Protein (His19-Glu563), C-10×His tagged | +Inquiry |
◆ Lysates | ||
CES1-7565HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
CES1-7564HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0207 | Carboxylesterase 1 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewReliable for lab work.
Great value for quality.
Good quality, great service.
Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
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