Carboxylesterase 1 Activity Assay Kit
Cat.No. : | Kit-0207 |
Product Overview : | (MS789) is a novel assay that uses a high affinity monoclonal capture antibody to selectively isolate carboxylesterase 1 (CES1) from liver tissue or cell samples. After isolation and subsequent measurement of the enzyme"s functional activity, the quantity of isolated CES1 is measured in the same well by adding a second monoclonal detector antibody, which is quantified using a colorimetric label (HRP). Both reactions take place in time-dependent manners proportional to the amount of enzyme captured in each well. By combining activity and quantity measurements, the enzyme"s relative specific activity can be determined. Specific activity is useful for measuring up or down regulation of activity by site-specific modification or damage, and in response to specific inhibitors. |
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Size : | 1 x 96 well plate |
Applications : | Functional Studies |
Storage : | Store all components at 4°C. This kit is Stable for 6 months fromreceipt. Unused microplate strips should be returned to the pouch containing the desiccant and resealed. |
Products Types
◆ Recombinant Protein | ||
CES1-654H | Recombinant Human CES1 protein, His-tagged | +Inquiry |
CES1-602H | Recombinant Human CES1 Protein, His-tagged | +Inquiry |
Ces1-5787M | Recombinant Mouse Ces1 protein, His&Myc-tagged | +Inquiry |
CES1-13H | Active Recombinant Human CES1 Protein (His19-Glu563), C-10×His tagged | +Inquiry |
CES1-1148H | Recombinant Human CES1 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CES1-7565HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
CES1-7564HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewReliable for lab work.
Great value for quality.
Good quality, great service.
Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
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