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Carboxylesterase 1 Activity Assay Kit

Cat.No. : Kit-0207
Product Overview : (MS789) is a novel assay that uses a high affinity monoclonal capture antibody to selectively isolate carboxylesterase 1 (CES1) from liver tissue or cell samples. After isolation and subsequent measurement of the enzyme"s functional activity, the quantity of isolated CES1 is measured in the same well by adding a second monoclonal detector antibody, which is quantified using a colorimetric label (HRP). Both reactions take place in time-dependent manners proportional to the amount of enzyme captured in each well. By combining activity and quantity measurements, the enzyme"s relative specific activity can be determined. Specific activity is useful for measuring up or down regulation of activity by site-specific modification or damage, and in response to specific inhibitors.
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Size : 1 x 96 well plate
Applications : Functional Studies
Storage : Store all components at 4°C. This kit is Stable for 6 months fromreceipt. Unused microplate strips should be returned to the pouch containing the desiccant and resealed.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the CES1 enzyme in the human body? 09/01/2022

CES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.

In which tissues or organs is CES1 most abundantly expressed? 07/10/2021

CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.

How does CES1 contribute to drug metabolism? 09/14/2020

It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.

What is the significance of CES1 in the metabolism of prodrugs? 05/04/2020

CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.

How can genetic variations in the CES1 gene affect drug response? 03/08/2020

Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.

Are there known inhibitors or activators of CES1, and how might they influence its activity? 04/06/2019

Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.

What role does CES1 play in lipid metabolism? 02/13/2018

It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.

Customer Reviews (3)

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Reviews
03/29/2022

    Reliable for lab work.

    09/16/2021

      Great value for quality.

      09/03/2020

        Good quality, great service.

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