Recombinant Human CES1 Protein, His-tagged
Cat.No. : | CES1-602H |
Product Overview : | Recombinant Human CES1(Gly18~Leu299) fused with His tag at N-terminal was expressed in E. coli. |
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Description : | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 34.0kDa |
Protein length : | Gly18~Leu299 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | CES1 carboxylesterase 1 [ Homo sapiens ] |
Official Symbol : | CES1 |
Synonyms : | CES1; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); liver carboxylesterase 1; CEH; CES1A1; CES1A2; CES2; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; SES1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; REH; TGH; ACAT; PCE-1; MGC117365; |
Gene ID : | 1066 |
mRNA Refseq : | NM_001025194 |
Protein Refseq : | NP_001020365 |
UniProt ID : | P23141 |
Products Types
◆ Recombinant Protein | ||
CES1-654H | Recombinant Human CES1 protein, His-tagged | +Inquiry |
CES1-13H | Active Recombinant Human CES1 Protein (His19-Glu563), C-10×His tagged | +Inquiry |
CES1-1148H | Recombinant Human CES1 Protein, GST-Tagged | +Inquiry |
Ces1-5787M | Recombinant Mouse Ces1 protein, His&Myc-tagged | +Inquiry |
CES1-748H | Active Recombinant Human CES1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CES1-7565HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
CES1-7564HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0207 | Carboxylesterase 1 Activity Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewReliable for lab work.
Great value for quality.
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Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
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