chek1
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  • Official Full Name
  • checkpoint kinase 1
  • Background
  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • CHEK1; checkpoint kinase 1; CHK1; serine/threonine-protein kinase Chk1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
Cat.#:CHEK1-1220HTag:GST|His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CHEK1 Protein, GST-His-Tagged
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Cat.#:CHEK1-1221HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHEK1 Protein, GST-Tagged
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Cat.#:CHEK1-3217HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CHEK1 Protein, MYC/DDK-tagged
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Cat.#:CHEK1-281HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CHEK1, His-tagged, Active
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Cat.#:CHEK1-229HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CHEK1 Protein, GST-tagged
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Cat.#:CHEK1-26453THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CHEK1
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Cat.#:CHEK1-26454THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHEK1
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Cat.#:CHEK1-26714THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CHEK1, His-tagged
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Cat.#:CHEK1-39HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CHEK1 protein, Flag-tagged, Biotinylated
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Cat.#:CHEK1-4838HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CHK1 Checkpoint Homolog (S. pombe), GST-tagged
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Cat.#:CHEK1-629HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CHEK1
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Cat.#:Chek1-1833MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chek1 protein, His & T7-tagged
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Cat.#:Chek1-8670MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Chek1, His & GST tagged
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Cat.#:CHEK1-1368RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CHEK1 Protein
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Cat.#:CHEK1-10539ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CHEK1
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Cat.#:CHEK1-1125HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameCHK1 Checkpoint Homolog (S. pombe)
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Cat.#:CHEK1-1132HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CHK1 Checkpoint Homolog (S. Pombe) , GST-tagged
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Cat.#:CHEK1-438HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CHEK1 cell lysate
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Cat.#:CHEK1-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CHEK1 cell lysate
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Involved Pathway

CHEK1 involved in several pathways and played different roles in them. We selected most pathways CHEK1 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of ATR in response to replication stress
HUS1; CHEK1; MCM8; RAD17; MCM10; RAD9; RAD9A; CDK2; RAD1; DBF4
Cell Cycle
GSK3B; ATM; NUDC; PDS5A; BRCC3; UBE2V2; PLK4; CLASP1; CENPW; TUBGCP4
Cell Cycle Checkpoints
THRSP; RAD9A; BRE; RAD9B; HIST3H2BB; BARD1; CDK5RAP2; FAM175A; RAD50; YWHAQ
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
CHEK1
Circadian rhythm pathway
NONO; DEC1; TIMELESS; CHEK1
DNA Double-Strand Break Repair
RAD17; EYA4; CHEK1; RAD9B; RAD50; EME2; RBBP8; RNF168; TDP1; FUZ
DNA Repair
RAD17; BAZ1B; CHEK2; ALKBH2; ERCC8; COPS7B; TP53BP1; USP45; EME1; COPS4

Protein Function

CHEK1 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-T11 specific), protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK1 itself. We selected most functions CHEK1 had, and list some proteins which have the same functions with CHEK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACTA1A; SMARCA4; XYLB; BAZ1B; PRKG1A; XRCC2; CDC7; MAP2K6; FBXO18; EHD4
Function histone kinase activity (H3-T11 specific)
Related Protein PKN1; CHEK1
Function protein binding
Related Protein SIRT6; RB1; POR; COPRS; C6orf108; RPS28; LXN; NME4; C22orf13; DAPK2
Function protein kinase activity
Related Protein CAMK2D2; RPS6KA3; CDK11A; RPS6KB2; SRPK1; IKBKAP; HIPK3; PRKACBB; STK26; PRKAA2
Function protein serine/threonine kinase activity
Related Protein CDK16; MAST4; IKBKB; CDK14; TLK1B; STK32B; PKMYT1; STK10; ATM; VPRBP

Interacting Protein

CHEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK1.
HSP90AB1; N/A; CDC25C; SMURF1; YWHAG