cxcl3
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 3
  • Background
  • Cytokine-induced neutrophil chemo attractant 1(CINC-1) was originally purified from media conditioned by IL-1βstimulated rat kidney epithelioid cells (NRK-52E). Amino acid sequence that encodes for rat CINC-1 was identified in 1989 by Watanabe's group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β, CINC-3/MIP-2. In addition, GROα, GROβ and GROγ is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs.
  • Synonyms
  • Cxcl3; Cinc2; Cinc-2; Gm1960; chemokine (C-X-C motif) ligand 3; GRO-gamma; SCYB3; GRO-gamma(1-73); GRO3; MIP2-beta; CINC-2b; MIP2B; GROg; MIP-2b; C-X-C motif chemokine 3; GRO3 oncogene; melanoma growth stimulatory activity gamma; Growth-regulated protein gamma; MGSA gamma2; Macrophage inflammatory protein 2-beta; GROG; C-X-C motif chemokine 3; MIP2-alpha/beta; macrophage inflammatory protein 2-alpha/beta; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2
Cat.#:Cxcl3-349MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Cxcl3 Protein, His-tagged
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Cat.#:CXCL3-2171HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL3 Protein, GST-tagged
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Cat.#:CXCL3-432CTag:His
Source (Host):E. coliSpecies:Cynomolgus
Product nameRecombinant Cynomolgus CXCL3 Protein, His-tagged
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Cat.#:Cxcl3-373MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 3
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Cat.#:Cxcl3-624MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 3, His-tagged
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Cat.#:Cxcl3-439RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-X-C motif) Ligand 3
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Cat.#:CXCL3-163HTag:MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) ligand 3, MBP-tagged
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Cat.#:CXCL3-16HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 3
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Cat.#:CXCL3-18HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CXCL3
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Cat.#:CXCL3-234HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged, mutant
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Cat.#:CXCL3-235HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 3, MIgG2a Fc-tagged
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Cat.#:CXCL3-236HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged
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Cat.#:CXCL3-29038THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL3
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Cat.#:CXCL3-29040THTag:MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL3, MBP-tagged
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Cat.#:CXCL3-29041THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL3, His-tagged
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Cat.#:CXCL3-84HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 3, His-tagged
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Cat.#:CXCL3-4106MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCL3 Protein
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Cat.#:Cxcl3-610MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl3
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Cat.#:CXCL3-1690RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CXCL3 Protein
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Cat.#:Cxcl3-437RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl3
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Cat.#:Cxcl3-627RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl3
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Cat.#:CXCL3-434CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CXCL3 protein, His-tagged
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Cat.#:CXCL3-1110RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCL3 Protein, His-tagged
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Cat.#:CXCL3-207HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL3 lysate
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Involved Pathway

CXCL3 involved in several pathways and played different roles in them. We selected most pathways CXCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF13B; GM10591; CLCF1; Flt3l; CXCL6; PDGFAA; GHRA; IFNA6; FAS; CXCL3
Chemokine signaling pathway
CXCL5; CCL2; PTK2B; CRK; GSK3A; LYN; IKBKB; CCL11; CRKL; NCF1
TNF signaling pathway
PIK3CG; TRAF3; TRAF5; AKT2; MAP3K5; CCL2; BIRC2; MMP3; Casp3; MMP9
Salmonella infection
NLRC4; ACTB1; IFNG; CCL3L3; MAPK12; NOS2B; MAPK10; CASP1; MAPK8B; MAPK8A
Legionellosis
CXCL3; SEC22B; IL12B; CASP9; HSPA2; HSPA8; Itgam&Itgb2; TLR2; SAR1B; TNF

Protein Function

CXCL3 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL3 itself. We selected most functions CXCL3 had, and list some proteins which have the same functions with CXCL3. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein CXCL18B; IL8L2; CXCL12A; CXCL12; CXCL3; CXCL2; CXCL5; PPBP; CXCL20; PF4V1
Function chemokine activity
Related Protein CCL34B.9; PF4; CX3CL1; CCL20; CCL26; CCL25B; CCL5; IL-8; CCL20B; CXCL12

CXCL3 Related Articles

See, ALP; Chong, PK; et al. CXCL3 is a Potential Target for Breast Cancer Metastasis. CURRENT CANCER DRUG TARGETS 14:294-309(2014).
Girolomoni, G; Mrowietz, U; et al. Psoriasis: rationale for targeting interleukin-17. BRITISH JOURNAL OF DERMATOLOGY 167:717-724(2012).

CXCL3 Related Gene Family

Chemokines Cytokines