cxcr2
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  • Official Full Name
  • chemokine (C-X-C motif) receptor 2
  • Background
  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms
  • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B
Cat.#:CXCR2-2179HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR2 Protein, GST-tagged
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Cat.#:CXCR2-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCR2 protein, MYC/DDK-tagged
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Cat.#:CXCR2-2097HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR2 protein, His & GST-tagged
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Cat.#:CXCR2-21HCLTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human CXCR2 HEK293T cell lysate
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Cat.#:CXCR2-22HCLTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human CXCR2 HEK293T cell lysate
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Cat.#:CXCR2-26726THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR2
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Cat.#:IL8RB-14213HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL8RB, GST-tagged
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Cat.#:CXCR2-4108MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCR2 Protein
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Cat.#:CXCR2-1693RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CXCR2 Protein
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Cat.#:CXCR2-5463CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCR2
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Cat.#:CXCR2-7163HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCR2 293 Cell Lysate
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Cat.#:Kit-0876Tag:
Source (Host):Species:
Product nameContinuous ITP pyrophosphatase Assay Kit
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Cat.#:Kit-0877Tag:
Source (Host):Species:
Product namePNP Assay Kit
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Cat.#:Kit-1053Tag:
Source (Host):Species:
Product nameFactor IXa Activity Assay Kit (Fluorometric)
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Cat.#:Kit-1190Tag:
Source (Host):Species:
Product namecAMP CXCR2 (IL8RB) CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1191Tag:
Source (Host):Species:
Product nameCXCR2 (IL8RB) HEK 293 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1192Tag:
Source (Host):Species:
Product nameCXCR2 (IL8RB) CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1193Tag:
Source (Host):Species:
Product nameCXCR2 Activated GPCR Internalization Assay Kit
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Involved Pathway

CXCR2 involved in several pathways and played different roles in them. We selected most pathways CXCR2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PF4; LIF; GHRA; BMP7B; KIT; TNFSF12; CXCR3.1; IL21R.1; CCL25B; LTA
Chemokine signaling pathway
CCL4L2; PIK3R5; GNGT2; CCL4; GRK6; XCL1; PLCB1; JAK2; GNB4; PIK3R1
Phospholipase D signaling pathway
CXCR2; CYTH3; AKT2; CYTH2; LPAR6; Kitl; AGPAT3; PDGFA; PLCG1; Adcy4
Endocytosis
SH3GLB1A; HLA-A; PDGFRA; PRKCZ; TGFB2; DNM1B; NEDD4; CXCR4A; RUFY1; PARD3
Epithelial cell signaling in Helicobacter pylori infection
PTPN11; CXCR1; ATP6V1E2; CXCR2; ATP6V1D; MAPK12; MAPK9; JAM2; NFKB1; TJP1

Protein Function

CXCR2 has several biochemical functions, for example, C-X-C chemokine receptor activity, interleukin-8 binding, interleukin-8 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR2 itself. We selected most functions CXCR2 had, and list some proteins which have the same functions with CXCR2. You can find most of the proteins on our site.
Function
Related Protein
Function C-X-C chemokine receptor activity
Related Protein CCR9A; CXCR5; CXCR3; CXCR7; CCBP2; CXCR3.1; CXCR4; CXCR2; CXCR6; CXCR4A
Function interleukin-8 binding
Related Protein A2M; CXCR2; CXCR1
Function interleukin-8 receptor activity
Related Protein CXCR1; CXCR2
Function protein binding
Related Protein TSHR; FAM9A; TLR1; ZFYVE20; SNRPG; FAM162A; SNX2; OAZ3; MRPL41; TBL1X
Function signal transducer activity
Related Protein MIER1B; MRGPRA7; Fzd4; OLFR510; PLCL1; TAS2R117; OPN4.1; AKAP13; OLFR150; MIER1

Interacting Protein

CXCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR2.
CXCL8; GRIA1; fldA; ytpB; argH1; q81ye8_bacan

CXCR2 Related Articles

Anzai, A; Shimoda, M; et al. Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture. CIRCULATION RESEARCH 116:612-U138(2015).
Xia, JL; Xu, XJ; et al. The potential of CXCL5 as a target for liver cancer - what do we know so far?. EXPERT OPINION ON THERAPEUTIC TARGETS 19:141-146(2015).

CXCR2 Related Gene Family

GPCRs Chemokines Cytokines