fcgr2b
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  • Official Full Name
  • Fc fragment of IgG, low affinity IIb, receptor (CD32)
  • Background
  • The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32); CD32; FCG2; CD32B; FCGR2; IGFR2; low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Cat.#:FCGR2B-323HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B Protein, His & Avi-tagged, Biotinylated
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Cat.#:FCGR2B-3993HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR2B Protein
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Cat.#:FCGR2B-3994HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR2B Protein, GST-tagged
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Cat.#:FCGR2B-2971CTag:His/AVI
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FCGR2B protein, His/AVI-tagged
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Cat.#:FCGR2B-12820HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FCGR2B, GST-tagged
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Cat.#:FCGR2B-258HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B, His-tagged, Biotinylated
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Cat.#:FCGR2B-259HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B Protein, His-tagged, Biotinylated
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Cat.#:FCGR2B-2962HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B, His & AVI tagged
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Cat.#:FCGR2B-3820HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B, His-tagged
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Cat.#:FCGR2B-383HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fc fragment of IgG, low affinity IIb, receptor (CD32), His-tagged
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Cat.#:FCGR2B-403HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B Protein, His-tagged
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Cat.#:FCGR2B-650HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B, His tagged
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Cat.#:FCGR2B-7279HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FCGR2B, His tagged
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Cat.#:Fcgr2b-2968MTag:His/AVI
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fcgr2b, His & AVI Tagged, Biotinylated
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Cat.#:Fcgr2b-3994MTag:His/AVI
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fcgr2b, His & AVI tagged
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Cat.#:Fcgr2b-633MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Fcgr2b Protein, His-tagged
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Cat.#:Fcgr2b-648MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fcgr2b, His tagged
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Cat.#:Fcgr2b-4083RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fcgr2b, His tagged
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Cat.#:Fcgr2b-7143RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fcgr2b protein, His & T7-tagged
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Cat.#:FCGR2B-278CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey FCGR2B protein, His-tagged
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Cat.#:FCGR2B-2972CTag:His/AVI
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FCGR2B, His & AVI tagged
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Cat.#:FCGR2B-4543CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FCGR2B protein, His-tagged
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Cat.#:FCGR2B-520CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FCGR2B Protein, His-tagged
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Cat.#:FCGR2B-1676RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FCGR2B Protein, His-tagged
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Cat.#:FCGR2B-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FCGR2B cell lysate
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Cat.#:FCGR2B-1988HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR2B cell lysate
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Cat.#:FCGR2B-1942RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FCGR2B cell lysate
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Cat.#:FCGR2B-1994CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FCGR2B cell lysate
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Involved Pathway

FCGR2B involved in several pathways and played different roles in them. We selected most pathways FCGR2B participated on our site, such as Phagosome, Osteoclast differentiation, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
ATP6AP1B; FCGR3B; TUBB1; MRC2; FCGR2B; ITGAM; TUBA8L4; HLA-A; ATP6V0C; HLA-DPA1
Osteoclast differentiation
FCGR4; FCGR2C; TNFRSF1A; IFNG; PPP3R2; LILRA2; NOX3; PIK3CG; ITGB3; LILRA1
B cell receptor signaling pathway
SYK; GRB2; LYN; RAC1; DUSP4; DOK1; STAP1; PIK3AP1; MALT1; CD79B
Fc gamma R-mediated phagocytosis
cgr2b; PLA2G4A; RPS6KB1; PIP5K1C; RAC1; FCGR1A; GSN; PIP5K1B; AKT1; FCGR3A
Staphylococcus aureus infection
PLG; HLA-DOB; ITGB2; HLA-DMA; cgr2b; HLA-DRA; FPR2; FCGR2A; FGG; ITGB2L
Tuberculosis
RAB5C; EP300; MAPK3; MYD88; HLA-DOB; HLA-DRB4; IFNGR1; BAD; HLA-DRB3; Cd209g
Measles
IFNA21; PIK3R5; BBC3; IFNA7; IFNA2; IFNA17; IFNAR2; FASLG; NFKBIA; TYK2

Protein Function

FCGR2B has several biochemical functions, for example, IgG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2B itself. We selected most functions FCGR2B had, and list some proteins which have the same functions with FCGR2B. You can find most of the proteins on our site.
Function
Related Protein
Function IgG binding
Related Protein FCGR3B; FCER1G; FCGRT; CD247L; PIP; FCGR2C; cgr2b; FCGR2A; FCGR2B; UMOD
Function protein binding
Related Protein RAD50; SYT4; DIAP1; CTSZ; WDR25; CMTM5; TLR6; Mill2; ATF7; KIF5B

Interacting Protein

FCGR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2B.
PTPN6; IGHG1

FCGR2B Related Articles

Karpus, ON; Kiener, HP; et al. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. ARTHRITIS RESEARCH & THERAPY 17:-(2015).
Lee, CS; Ashton-Key, M; et al. Expression of the inhibitory Fc gamma receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98). BRITISH JOURNAL OF HAEMATOLOGY 168:145-148(2015).