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FCGR2B

  • Official Full Name

    Fc fragment of IgG, low affinity IIb, receptor (CD32)

  • Overview

    The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32); CD32; FCG2; CD32B; FCGR2; IGFR2; low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi
  • His
  • C
  • Flag
  • GST
  • His (Fc)
  • His|Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FCGR2B-259H Active Recombinant Human FCGR2B Protein, His-tagged, Biotinylated HEK293 His Ala 46 - Pro 217
Human FCGR2B-3820H Active Recombinant Human FCGR2B, His-tagged Human Cell His
Human FCGR2B-324H Active Recombinant Human FCGR2B Protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Ala 46-Ile 224
Human FCGR2B-051H Active Recombinant Human FCGR2B protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi (Ala46-Pro217
Human FCGR2B-3993H Recombinant Human FCGR2B Protein Wheat Germ N/A
Human FCGR2B-383H Recombinant Human Fc fragment of IgG, low affinity IIb, receptor (CD32), His-tagged E.coli His
Human FCGR2B-403H Recombinant Human FCGR2B Protein, His-tagged HEK293 His
Human FCGR2B-7279H Recombinant Human FCGR2B, His tagged CHO His
Human FCGR2B-3994H Recombinant Human FCGR2B Protein, GST-tagged Wheat Germ GST
Human FCGR2B-12820H Recombinant Human FCGR2B, GST-tagged E.coli GST C-term-57a.a.
Human FCGR2B-258H Recombinant Human FCGR2B, His-tagged, Biotinylated HEK293 His
Human FCGR2B-2962H Recombinant Human FCGR2B, His & AVI tagged Human Cell His/Avi
Human FCGR2B-650H Active Recombinant Human FCGR2B, His tagged HEK293 His Ala 46-Pro 217
Human FCGR2B-001HCL Recombinant Human FCGR2B cell lysate CHO N/A
Human FCGR2B-1988HCL Recombinant Human FCGR2B cell lysate Human Cell N/A
Human FCGR2B-01H Recombinant Human FCGR2B protein, Myc/DDK-tagged HEK293T Myc/DDK
Human FCGR2B-3789H Recombinant Human FCGR2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FCGR2B-323H Active Recombinant Human FCGR2B Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Ala 46 - Pro 217
Human FCGR2B-1077HFL Recombinant Full Length Human FCGR2B Protein, C-Flag-tagged Mammalian cells Flag
Human FCGR2B-6532H Active Recombinant Human FCGR2B Protein, His-tagged HEK293 His Ala46-Pro217
Human FCGR2B-032H Recombinant Human FCGR2B Protein, C-His-tagged E.coli C-His
Human FCGR2B-1800H Recombinant Human FCGR2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FCGR2B-544H Recombinant Human FCGR2B Protein HEK293 310
Human FCGR2B-900H Recombinant Human FCGR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FCGR2B-2615H Active Recombinant Human FCGR2B protein, His-tagged HEK293 His Ala46-Pro217
Human FCGR2B-02H Recombinant Human FCGR2B protein, Myc/DDK-tagged HEK293T Myc/DDK
Human FCGR2B-900H-B Recombinant Human FCGR2B Protein Pre-coupled Magnetic Beads HEK293
Human FCGR2B-2595H Recombinant Human FCGR2B Protein (Thr43-Pro217), C-His tagged Mammalian cells C-His Thr43-Pro217
Human FCGR2B-1208H Recombinant Human FCGR2B Protein (Ala46-Pro217), N-His tagged E.coli N-His Ala46-Pro217
Human FCGR2B-4757HF Recombinant Full Length Human FCGR2B Protein In Vitro Cell Free System 269 amino acids
Human FCGR2B-545H Recombinant Human FCGR2B Protein HEK293 310
Mouse Fcgr2b-633M Active Recombinant Mouse Fcgr2b Protein, His-tagged Mammalian cells His Thr40-Arg217
Mouse Fcgr2b-648M Active Recombinant Mouse Fcgr2b protein(Met1-Arg217), His-tagged HEK293 C-His Met1-Arg217
Mouse Fcgr2b-3994M Recombinant Mouse Fcgr2b, His & AVI tagged Human Cell His/Avi
Mouse Fcgr2b-2968M Active Recombinant Mouse Fcgr2b protein(Met1-Arg217), His&Avi-tagged, Biotinylated HEK293 C-His&Avi Met1-Arg217
Mouse Fcgr2b-3185M Recombinant Mouse Fcgr2b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fcgr2b-3185M-B Recombinant Mouse Fcgr2b Protein Pre-coupled Magnetic Beads HEK293
Mouse FCGR2B-1441M Active Recombinant Mouse FCGR2B protein, Avi-His-tagged, Biotinylated HEK293 Avi-His Thr40-Arg217
Mouse Fcgr2b-468M Active Recombinant Mouse Fcgr2b protein, His-tagged HEK293 His Thr40-Arg217
Rat Fcgr2b-4083R Active Recombinant Rat Fcgr2b protein(Met1-Pro212), His-tagged HEK293 C-His Met1-Pro212
Rat Fcgr2b-7143R Recombinant Rat Fcgr2b protein, His & T7-tagged E.coli His/T7 Ile47~Ile285 (Accession # Q63203)
Rat FCGR2B-1942RCL Recombinant Rat FCGR2B cell lysate Human Cell N/A
Rat FCGR2B-1439R Active Recombinant Rat FCGR2B protein, His-tagged HEK293 His His32-Pro212
Cynomolgus FCGR2B-291C Active Recombinant Cynomolgus FCGR2B protein, His/Avi-tagged, Biotinylated HEK293 His/Avi Met 1-Gly 220
Cynomolgus FCGR2B-2972C Active Recombinant Cynomolgus FCGR2B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Met1-Gly220
Cynomolgus FCGR2B-4543C Active Recombinant Cynomolgus FCGR2B protein(Met1-Pro217), His-tagged HEK293 C-His Met1-Pro217
Cynomolgus FCGR2B-1440C Active Recombinant Cynomolgus FCGR2B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala46-Pro224
Cynomolgus FCGR2B-215C Active Recombinant Cynomolgus FCGR2B protein, His-tagged HEK293 His Ala46-Pro224
Cynomolgus Monkey FCGR2B-278C Active Recombinant Cynomolgus Monkey FCGR2B protein, His-tagged HEK293 His
Cynomolgus Monkey FCGR2B-2971C Recombinant Cynomolgus FCGR2B protein, His/AVI-tagged HEK293 His/Avi Met 1-Gly 220
Cynomolgus Monkey FCGR2B-1994CCL Recombinant Cynomolgus FCGR2B cell lysate Human Cell N/A
Homo sapiens (Human) RFL22602HF Recombinant Full Length Human Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B(Fcgr2B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (43-310)
Rhesus Macaque FCGR2B-1676R Recombinant Rhesus monkey FCGR2B Protein, His-tagged Mammalian Cell His
Rhesus Macaque FCGR2B-1499R-B Recombinant Rhesus Macaque FCGR2B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FCGR2B-1499R Recombinant Rhesus Macaque FCGR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FCGR2B Related Articles
  • FCGR2B Related Research Area

FCGR2B involved in several pathways and played different roles in them. We selected most pathways FCGR2B participated on our site, such as Phagosome, Osteoclast differentiation, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTHBS1;LAMP2;DYNC1LI1;RAB5AA;ITGB3;RAB5C;RAC1A;HLA-DPA1;TUBA2
Osteoclast differentiationPPP3R1;IFNAR1;FCGR1A;IKBKG;LILRB2;FCGR2B;PIK3CB;MAP3K14;STAT1
B cell receptor signaling pathwayVAV2;NFKB1;BCL2L11;INPPL1;ARPC5;LCP2A;NFKBIA;ACTR2;LAT2
Fc gamma R-mediated phagocytosisASAP3;WASF1;PIP5K1A;RAC2;MYO10;AKT1;PPAP2B;PIK3CA;PIK3CD
Staphylococcus aureus infectionFPR2;MASP1;Hc;FCGR1;C2;ITGAM;FPR3;HLA-DMB;HLA-DRB4
TuberculosisIFNA4;PMAP-36;IL10RB;IFNA16;IFNA2;HLA-DPA1;CLEC7A;HLA-DMA;ATP6V0D2
MeaslesCD209C;CBLB;IFNAR2;EIF2AK3;IL13;TYK2;HSPA8;IFNA2;IFNGR1

FCGR2B has several biochemical functions, for example, IgG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2B itself. We selected most functions FCGR2B had, and list some proteins which have the same functions with FCGR2B. You can find most of the proteins on our site.

Function Related Protein
IgG bindingFCGR3B;FCGR3A;FCGR1B;FCGR2B;PIP;FCGR1;UMOD;FCGR2C;CD247L
protein bindingTRIM54;SPPL2B;MLST8;NME4;PLGRKT;DACT2;NR4A1;EEF1A2;NPBWR1

FCGR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2B.

PTPN6; IGHG1

Karpus, ON; Kiener, HP; et al. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. ARTHRITIS RESEARCH & THERAPY 17:-(2015).
Lee, CS; Ashton-Key, M; et al. Expression of the inhibitory Fc gamma receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98). BRITISH JOURNAL OF HAEMATOLOGY 168:145-148(2015).
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