fgf18
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  • Official Full Name
  • fibroblast growth factor 18
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FGF18; fibroblast growth factor 18; ZFGF5; FGF-18;
Cat.#:FGF18-4108HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF18 Protein, GST-tagged
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Cat.#:FGF18-12867HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF18, GST-tagged
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Cat.#:FGF18-171HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 18
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Cat.#:FGF18-183HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF18 protein, His/S-tagged
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Cat.#:FGF18-222HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged, mutant
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Cat.#:FGF18-223HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 18, MIgG2a Fc-tagged
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Cat.#:FGF18-224HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged
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Cat.#:FGF18-504HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF18 Protein, His-tagged
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Cat.#:FGF18-522HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF18
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Cat.#:FGF18-655HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FGF18
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Cat.#:Fgf18-184MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf18 protein, His/S-tagged
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Cat.#:Fgf18-491MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgf18, His tagged
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Cat.#:Fgf18-562MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf18
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Cat.#:Fgf18-185RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgf18 protein, His/S-tagged
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Cat.#:FGF18-2330RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGF18 Protein
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Cat.#:Fgf18-588RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgf18
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Cat.#:FGF18-6279CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGF18
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Cat.#:FGF18-1660HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF18 cell lysate
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Cat.#:FGF18-2430MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGF18 cell lysate
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Involved Pathway

FGF18 involved in several pathways and played different roles in them. We selected most pathways FGF18 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D1A; GRB2B; STK3; HSPA1B; CACNB3A; PRKACAA; SRFA; TGFB1; HSPA1L; FGF16
Ras signaling pathway
PDGFRA; CALM2; Kitl; HGF; RAP1B; MAPK1; PIK3R5; FASLG; KIT; FGF19
Rap signaling pathway
RAP1B; NGFR; SIPA1L2; FGFR3; VAV2; MET; ITGB2; PIK3R1; IGF1; PIK3CG
PIK-Akt signaling pathway
TRP53; GNG8; TP53; EIF4E2; FASLG; INS1; HSP90AA1; IFNA7; IRS1; FGF18
Regulation of actin cytoskeleton
CD14; TMSB4X; ABI2; ITGB6; VAV3B; MSNA; GIT1; F2; SSH3; SRC
Pathways in cancer
APC; TRAF1; Kitl; FGF7; PML; Pdgfa&Pdgfb; WNT8A; WNT7A; EGLN3; MAP2K2
Melanoma
PDGFC; HGF; CCND1; RB1; MAPK1; FGF18; MET; CDH1; PIK3R3; PDGFRA

Protein Function

FGF18 has several biochemical functions, for example, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF18 itself. We selected most functions FGF18 had, and list some proteins which have the same functions with FGF18. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein Il2; JAG1; FGF11A; FGF2; GDF10B; F2; INHBC; FGF13B; NDP; NRTN
Function type 1 fibroblast growth factor receptor binding
Related Protein FGF8; FGF18; NPTN; FGF17
Function type 2 fibroblast growth factor receptor binding
Related Protein FGF10; FGF8; FGF18; FGF17; FGF7

Interacting Protein

FGF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF18.
LYAR

FGF18 Related Articles

Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Portela, VM; Dirandeh, E; et al. The Role of Fibroblast Growth Factor-18 in Follicular Atresia in Cattle. BIOLOGY OF REPRODUCTION 92:-(2015).