fgfr4
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  • Official Full Name
  • fibroblast growth factor receptor 4
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor;
Cat.#:FGFR4-2062HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4 Protein, Fc/His-tagged
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Cat.#:FGFR4-4140HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR4 Protein, GST-tagged
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Cat.#:FGFR4-4141HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR4 Protein, GST/His-tagged
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Cat.#:FGFR4-4142HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR4 Protein
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Cat.#:FGFR4-4143HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR4 Protein, GST-tagged
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Cat.#:FGFR4-5420HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 4, His-tagged
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Cat.#:FGFR4-04HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 4, Fc-tagged
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Cat.#:FGFR4-12882HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR4, His-tagged
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Cat.#:FGFR4-27013THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FGFR4, Fc-tagged
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Cat.#:FGFR4-28837THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR4
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Cat.#:FGFR4-316HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR4, GST-tagged, Active
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Cat.#:FGFR4-32HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4, MYC/DDK-tagged
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Cat.#:FGFR4-3845HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4, His tagged
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Cat.#:FGFR4-47HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR4 protein, Flag-tagged, Biotinylated
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Cat.#:FGFR4-4844HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 4, GST-tagged
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Cat.#:FGFR4-493HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 4
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Cat.#:FGFR4-613HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR4, His-tagged, Biotinylated
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Cat.#:FGFR4-614HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR4, Fc-tagged, Biotinylated
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Cat.#:FGFR4-707HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4, Fc-His tagged
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Cat.#:FGFR4-708HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4, Fc tagged
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Cat.#:FGFR4-792HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FGFR4 Protein, DDK/His-tagged
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Cat.#:FGFR4-90HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR4, GST-tagged
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Cat.#:FGFR4-91HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR4, GST-tagged
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Cat.#:FGFR4-92HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR4, GST-tagged
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Cat.#:FGFR4-93HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR4, GST-tagged
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Cat.#:Fgfr4-1812MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgfr4 protein, His & T7-tagged
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Cat.#:Fgfr4-709MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr4, His tagged
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Cat.#:Fgfr4-710MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr4, Fc-His tagged
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Cat.#:FGFR4-1076RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FGFR4 Protein, Fc-tagged
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Cat.#:FGFR4-2340RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGFR4 Protein
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Cat.#:Fgfr4-7432RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fgfr4, His tagged
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Cat.#:FGFR4-56CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR4, His tagged
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Cat.#:FGFR4-57CTag:Fc
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR4, Fc tagged
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Cat.#:FGFR4-82CTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR4 protein, His-tagged
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Cat.#:FGFR4-8839CTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR4 protein, Fc-tagged
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Cat.#:FGFR4-8998ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR4
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Cat.#:FGFR4-1907HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR4 cell lysate
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Cat.#:FGFR4-2757MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR4 cell lysate
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Cat.#:FGFR4-1516RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FGFR4 cell lysate
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Involved Pathway

FGFR4 involved in several pathways and played different roles in them. We selected most pathways FGFR4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF1B; NGF; RAC3; RPS6KA3B; FGF13; RELB; GADD45AB; FGF20; MAP2K7; PDGFB
Ras signaling pathway
RAP1B; SHC2; RALB; TBK1; EFNA4; SOS1; VEGFB; SHOC2; FGFR4; ELK1
Rap signaling pathway
PGF; PIK3CG; FARP2; PRKD1; RRAS; AKT1; PIK3CD; ITGB1; VEGFA; HRAS
Endocytosis
MHC1UXA2; CAPZA2; HRASB; RAB11B; CAV3; CDC42L; NTRK1; WASH1; IGF1RA; CAPZA1B
PIK-Akt signaling pathway
SOS1; ITGA5; TCL1B1; FGF10; LAMA5; CREB3L2; CREB5; SPP1; PPP2R1A; KRAS
Signaling pathways regulating pluripotency of stem cells
AXIN2; WNT2B; GRB2; BMPR1A; JARID2; PIK3R3; LEFTY2; HESX1; LIFR; PCGF3
Regulation of actin cytoskeleton
MAPK6; PPP1R12C; PIK3R2; MYH9; PIK3R5; PIP4K2B; BRK1; ROCK2; ITGB7; CD14

Protein Function

FGFR4 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR4 itself. We selected most functions FGFR4 had, and list some proteins which have the same functions with FGFR4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Abcb1b; PET112L; PRKACG; GTF2F2B; HSPA4; CSK; ABCC9; KIF1B; SYN2B; DAPK2
Function fibroblast growth factor binding
Related Protein FGFRL1; CEP57; Api5; GLG1B; RPS2; GLG1; CXCL13; TGFBR3; KLB; FGFR1A
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR2; FGFRL1; FGFR4; FGFR1A; FGFR1B; FGFR3; FGFR1
Function heparin binding
Related Protein CTGFA; TGFBR3; FGF14; FMODA; GPNMB; Epy; SLIT1; HDGF; COL13A1; VEGFB
Function protein binding
Related Protein ITGB3; MAPK10; NUB1; MAB21L1; INIP; CDK9; NAA35; USP37; MSH6; SMARCC2
Function protein tyrosine kinase activity
Related Protein MAP2K1; FES; INSRB; ERBB2; HCK; TNK2B; EGFRA; ERBB4A; MAP3K11; IGF1RB

Interacting Protein

FGFR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR4.
saicar; ssr; PKM; FGF1; FGF5; CASC3; GLCE; DIRAS3; RNF20; BLID; THRSP; EPSTI1; PDLIM2; FAM84B; SCGB3A1; RASL10B; MTA3

FGFR4 Related Articles

Herbert, C; Gueguen-Dorbes, G; et al. Anti-FGFR4 monoclonal antibody for the treatment of hepatocellular carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:S10-S10(2014).
Muchekehu, R; Liu, DG; et al. The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs. TRANSLATIONAL ONCOLOGY 6:562-+(2013).

FGFR4 Related Gene Family

Cytokines