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Official Full Name fibroblast growth factor receptor 4
Background The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
Synonyms FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Flag
    • GST
    • hFc
    • T7
    • His-Avi
    • Myc/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGFR4-062HB Recombinant Human FGFR4 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human FGFR4-140H Recombinant Human FGFR4 protein, His-Avi-tagged HEK293 His-Avi
    Human FGFR4-141H Recombinant Human FGFR4 protein, hFc-tagged HEK293 hFc
    Human FGFR4-2062H Recombinant Human FGFR4 Protein, Fc/His-tagged HEK293 Fc/His
    Mouse Fgfr4-3004M Recombinant Mouse Fgfr4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human FGFR4-5801H Recombinant Human FGFR4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FGFR4-04H Recombinant Human Fibroblast Growth Factor Receptor 4, Fc-tagged Insect Cell Fc
    Human FGFR4-12882H Recombinant Human FGFR4, His-tagged E.coli His
    Human FGFR4-1907HCL Recombinant Human FGFR4 cell lysate Human Cell N/A
    Human FGFR4-27013TH Recombinant Human FGFR4, Fc-tagged Fc
    Human FGFR4-28837TH Recombinant Human FGFR4 N/A
    Human FGFR4-316H Recombinant Human FGFR4, GST-tagged, Active Sf9 Insect Cell GST
    Human FGFR4-32H Recombinant Human FGFR4, MYC/DDK-tagged HEK293 Myc/DDK
    Human FGFR4-3845H Recombinant Human FGFR4 protein, His-tagged HEK293 His
    Human FGFR4-4140H Recombinant Human FGFR4 Protein, GST-tagged Insect Cell GST
    Human FGFR4-4141H Recombinant Human FGFR4 Protein, GST/His-tagged Insect Cell GST/His
    Human FGFR4-4142H Recombinant Human FGFR4 Protein Wheat Germ N/A
    Human FGFR4-4143H Recombinant Human FGFR4 Protein, GST-tagged Wheat Germ GST
    Human FGFR4-47H Recombinant Human FGFR4 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human FGFR4-4844H Recombinant Human Fibroblast Growth Factor Receptor 4, GST-tagged Sf9 Insect Cell GST
    Human FGFR4-493H Recombinant Human Fibroblast Growth Factor Receptor 4 NSO N/A
    Human FGFR4-5420H Recombinant Human Fibroblast Growth Factor Receptor 4, His-tagged Insect Cell his
    Human FGFR4-613H Recombinant Human FGFR4, His-tagged, Biotinylated Human Cell His
    Human FGFR4-614H Recombinant Human FGFR4, Fc-tagged, Biotinylated Human Cell Fc
    Human FGFR4-707H Recombinant Human FGFR4, Fc-His tagged Human Cell Fc/His
    Human FGFR4-708H Recombinant Human FGFR4, Fc tagged Human Cell Fc
    Human FGFR4-792H Recombinant Human FGFR4 Protein, DDK/His-tagged HEK293 DDK/His
    Human FGFR4-90H Recombinant Human FGFR4, GST-tagged Sf9 Insect Cell GST
    Human FGFR4-91H Recombinant Human FGFR4, GST-tagged Sf9 Insect Cell GST
    Human FGFR4-92H Recombinant Human FGFR4, GST-tagged Sf9 Insect Cell GST
    Human FGFR4-93H Recombinant Human FGFR4, GST-tagged Sf9 Insect Cell GST
    Mouse Fgfr4-1812M Recombinant Mouse Fgfr4 protein, His & T7-tagged E.coli His/T7
    Mouse FGFR4-2757MCL Recombinant Mouse FGFR4 cell lysate Human Cell N/A
    Mouse Fgfr4-709M Recombinant Mouse Fgfr4 protein, His-tagged HEK293 His
    Mouse Fgfr4-710M Recombinant Mouse Fgfr4, Fc-His tagged Human Cell Fc/His
    Rat FGFR4-1076R Recombinant Rat FGFR4 Protein, Fc-tagged HEK293 Fc
    Rat FGFR4-1516RCL Recombinant Rat FGFR4 cell lysate Human Cell N/A
    Rat FGFR4-2340R Recombinant Rat FGFR4 Protein Mammalian Cell His
    Rat Fgfr4-7432R Recombinant Rat Fgfr4, His tagged Human Cell His
    Cynomolgus Monkey FGFR4-56C Recombinant Cynomolgus FGFR4, His tagged Mammalian Cell His
    Cynomolgus Monkey FGFR4-57C Recombinant Cynomolgus FGFR4, Fc tagged Mammalian Cell Fc
    Rhesus Macaque FGFR4-82C Recombinant Rhesus FGFR4 protein, His-tagged HEK293 His
    Rhesus Macaque FGFR4-8839C Recombinant Rhesus FGFR4 protein, Fc-tagged HEK293 Fc
    Zebrafish FGFR4-8998Z Recombinant Zebrafish FGFR4 Mammalian Cell His

    FGFR4 involved in several pathways and played different roles in them. We selected most pathways FGFR4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RAP1AB; HSPA1A; MAP2K4; CACNB2A; IL1B; PPP3CCA; TGFB2; PRKACBB; HSPB1; FGF20B
    Ras signaling pathway NGFR; ABL1; GAB2; RAF1; PLA2G12A; PLA2G4C; FGF17; GNB1; BCL2L1; PRKACA
    Rap signaling pathway CALML5; Pdgfa&Pdgfb; PIK3CG; FGF2; FGF9; PDGFC; GRIN2A; PIK3CB; PARD6A; ITGB1
    PIK-Akt signaling pathway PIK3CA; IL6R; RELA; TP53; FGF7; ITGB6; GNG4; TLR4; Itga10&Itgb1; PPP2R3A
    Signaling pathways regulating pluripotency of stem cells PIK3R2; PAX6; AKT1; KLF4; BMP2; HAND1; FZD9; FZD3; ONECUT1; BMPR1A
    Regulation of actin cytoskeleton FGF20; RAC3; FGF19; ENAH; ITGAM; WASLA; ITGA3B; RHOA; ITGB5; PPP1CAA

    FGFR4 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR4 itself. We selected most functions FGFR4 had, and list some proteins which have the same functions with FGFR4. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor binding FIBPB; FGFRL1; PTPRZ1; S100A13; FIBPA; FGFBP1; GLG1; THBS1; RPS19; FGFBP3
    fibroblast growth factor-activated receptor activity FGFR1; FGFR1A; FGFRL1; FGFR3; FGFR4; FGFR2; FGFR1B
    heparin binding SFRP1; KAL1; TENM1; RSPO3; NRP1; FGFBP3; VTN; APOE; VEGFAA; HBEGF
    protein binding PKD2; JAK1; TSTD2; BCL2A1A; ALOX15; LANCL2; NME3; ZNF155; HES1; SLC9A1
    protein tyrosine kinase activity RET; Aatk; KIAA1804; DSTYK; IGF1R; PTK6B; LYN; TYK2; FES; TNK2

    FGFR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR4.


    Herbert, C; Gueguen-Dorbes, G; et al. Anti-FGFR4 monoclonal antibody for the treatment of hepatocellular carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:S10-S10(2014).
    Muchekehu, R; Liu, DG; et al. The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs. TRANSLATIONAL ONCOLOGY 6:562-+(2013).

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