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Recombinant Human FGFR4 Protein, His-tagged, Alexa Fluor 647 conjugated

Cat.No. : FGFR4-3845HAF647
Product Overview : Alexa Fluor 647 conjugated recombinant human FGFR4 (Leu22-Asp369) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized
Molecular Mass : The protein has a calculated MW of 40.0 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Leu22-Asp369
N-terminal Sequence Analysis : Leu 22
Endotoxin : < 1.0 EU/ μg by the LAL method.
Purity : > 98 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 647 via amines
Excitation = 650 nm
Emission = 668 nm
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : FGFR4
Official Symbol : FGFR4
Synonyms : FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292
Gene ID : 2264
mRNA Refseq : NM_002011
Protein Refseq : NP_002002
MIM : 134935
UniProt ID : P22455

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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