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Recombinant Human FGFR4 Protein, DYKDDDDK-tagged

Cat.No. : FGFR4-152H
Product Overview : Recombinant Human fibroblast growth factor receptor 4(FGFR4), transcript variant 1(NM_002011), with a DYKDDDDK tag, was expressed in human cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Source : Human Cells
Species : Human
Tag : DYKDDDDK
Form : Purified protein formulated in a sterile solution of TBS buffer, pH7.172, without any preservatives.
Molecular Mass : 41 kDa
Endotoxin : Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Purity : >90% by SDS-PAGE gel and Coomassie Blue staining
Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.
Gene Name : FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ]
Official Symbol : FGFR4
Synonyms : FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292;
Gene ID : 2264
mRNA Refseq : NM_002011
Protein Refseq : NP_002002
MIM : 134935
UniProt ID : P22455

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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