Active Recombinant Human FGFR4 Homodimer Protein, His&Avi tagged

• Cat.No.: FGFR4-41H
• Product Overview: FGFR4 dimer protein contains a FGFR4 extracellular domain (UniProt# P22455) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 22-369 aa
• Description: Human fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor belonging to the immunoglobulin superfamily and a transmembrane receptor tyrosine kinase (RTK) that belongs to the FGFR family. FGFR4 is also known as cluster of differentiation 334 (CD334), JTK2, and TKF. FGFR4 contains an extracellular domain with three immunoglobulin-like (Ig-like) subdomains (D1, D2 and D3), followed by a transmembrane, and an intracellular domain. Dimerization of FGFRs is necessary for activation and they can homodimerize and heterodimerize in both the presence and absence of ligand. FGFRs bind fibroblast growth factors (FGFs) leading to phosphorylation and triggering signaling cascades. FGFR4 has been implicated in oncogenesis, tumor progression, and resistance to anti-tumor therapy in multiple types of cancer making it an emerging target for cancer therapeutics.
• Molecular Mass: 97 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for FGFR4-specific antibody binding assay and BLI for fibroblast growth factor 1 (FGF-1) ligand protein binding assays. Suggested Applications: SPR for FGFR4-specific antibody and FGF-1 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens (human) ]
• Official Symbol: FGFR4
• Synonyms: FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• MIM: 134935
• UniProt ID: P22455