Recombinant Human FGFR4 Protein, His-tagged

• Cat.No.: FGFR4-248H
• Product Overview: Recombinant human FGFR4 protein with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 40 kDa
• Protein Length: 802
• AA Sequence: MRLLLALLGVLLSVPGPPVLSLEAS EEVELEPCLAPSLEQQEQELTVALG QPVRLCCGRAERGGHWYKEGSRLAP AGRVRGWRGRLEIASFLPEDAGRYL CLARGSMIVLQNLTLITGDSLTSSN DDEDPKSHRDPSNRHSYPQQAPYWT HPQRMEKKLHAVPAGNTVKFRCPAA GNPTPTIRWLKDGQAFHGENRIGGI RLRHQHWSLVMESVVPSDRGTYTCL VENAVGSIRYNYLLDVLERSPHRPI LQAGLPANTTAVVGSDVELLCKVYS DAQPHIQWLKHIVINGSSFGADGFP YVQVLKTADINSSEVEVLYLRNVSA EDAGEYTCLAGNSIGLSYQSAWLTV LPEEDPTWTAAAPEARYTDIILYAS GSLALAVLLLLAGLYRGQALHGRHP RPPATVQKLSRFPLARQFSLESGSS GKSSSSLVRGVRLSSSGPALLAGLV SLDLPLDPLWEFPRDRLVLGKPLGE GCFGQVVRAEAFGMDPARPDQASTV AVKMLKDNASDKDLADLVSEMEVMK LIGRHKNIINLLGVCTQEGPLYVIV ECAAKGNLREFLRARRPPGPDLSPD GPRSSEGPLSFPVLVSCAYQVARGM QYLESRKCIHRDLAARNVLVTEDNV MKIADFGLARGVHHIDYYKKTSNGR LPVKWMAPEALFDRVYTHQSDVWSF GILLWEIFTLGGSPYPGIPVEELFS LLREGHRMDRPPHCPPELYGLMREC WHAAPSQRPTFKQLVEALDKVLLAV SEEYLDLRLTFGPYSPSGGDASSTC SSSDSVFSHDPLPLGSSSFPFGSGV QT
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens (human) ]
• Official Symbol: FGFR4
• Synonyms: FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• MIM: 134935
• UniProt ID: P22455