il12rb2
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  • Official Full Name
  • interleukin 12 receptor, beta 2
  • Background
  • The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
  • Synonyms
  • IL12RB2; interleukin 12 receptor, beta 2; interleukin-12 receptor subunit beta-2; I12R2_HUMAN; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1; IL-12 receptor beta 2; interleukin-12 receptor beta-2 chain; RP11-102M16.1
Cat.#:IL12RB2-3885HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL12RB2 protein, His-tagged
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Cat.#:IL12RB2-1464HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12RB2 protein, His-tagged
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Cat.#:IL12RB2-1465HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12RB2 protein, His & GST-tagged
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Cat.#:IL12RB2-29640THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IL12RB2
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Cat.#:IL12RB2-3884HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL12RB2 protein, His-tagged
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Cat.#:Il12rb2-1466MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12rb2 protein, His-tagged
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Cat.#:Il12rb2-1467MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12rb2 protein, His-tagged
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Cat.#:Il12rb2-4006MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il12rb2, His tagged
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Cat.#:IL12RB2-5006CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL12RB2
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Cat.#:IL12RB2-6304ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL12RB2
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Cat.#:IL12RB2-2142MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12RB2 cell lysate
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Involved Pathway

Il12rb2 involved in several pathways and played different roles in them. We selected most pathways Il12rb2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il12rb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL14; CCL18; FLT3LG; IL7R; CCR9; BMPR1A; IL11; IFNG1-2; CCL3L1; INHBA
Jak-STAT signaling pathway
RNF207B; HRASB; STAM; IFNAR2; PIAS4A; IFNB1; IL4; PRL2; CCND2; IL17D
Inflammatory bowel disease (IBD)
IL13; IL21; Il4ra; Il23a; Il12b; STAT3; NFKB1; IL2RG; HLA-DMA; STAT1; IFNGR2

Protein Function

Il12rb2 has several biochemical functions, for example, cytokine receptor activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il12rb2 itself. We selected most functions Il12rb2 had, and list some proteins which have the same functions with Il12rb2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein FLT3; IL15RA; IL13RA2; GHRA; F3B; PRLRA; IL1RL1; IL2RGB; CRFB2; IL20RB
Function protein kinase binding
Related Protein CDC25C; MAPK6; RPS3; PPP1R12B; PRKAB1; IL12RB2; DVL1; FAF1; GSTP2; SLC12A5

Interacting Protein

Il12rb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il12rb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il12rb2.
STAT4; SOCS3

Il12rb2 Related Articles

Holle, JU; Gross, WL; et al. Genetic risk factors for vasculitis. INTERNIST 55:128-+(2014).
Cho, S; Kim, J; et al. Immunopathogenic characterization of cutaneous inflammation in Behcet's disease. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:51-57(2014).

Il12rb2 Related Gene Family

IL