IL12RB2-1465H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Human IL12RB2 aa. (Tyr559~Gln647 (Accession # Q99665)) fused with N-terminal His & GST tag was produced in E. coli cells.
Description :
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Source :
E. coli
Species :
Human
Tag :
His & GST
Form :
Freeze-dried powder
Molecular Mass :
Predicted Molecular Mass: 42.6kDa.
Protein length :
Tyr559~Gln647 (Accession # Q99665)
Endotoxin :
<1.0EU per 1µg (determined by the LAL method).
Purity :
>95%
Characteristic :
The isoelectric point is 9.1.
Applications :
SDS-PAGE; WB; ELISA; IP.
Stability :
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage :
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer :
Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.