Recombinant Human IL12RB2 protein, His & GST-tagged
Cat.No. : | IL12RB2-1465H |
Product Overview : | Recombinant Human IL12RB2 aa. (Tyr559~Gln647 (Accession # Q99665)) fused with N-terminal His & GST tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His&GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 42.6kDa. |
Protein length : | Tyr559~Gln647 (Accession # Q99665) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method). |
Purity : | >95% |
Characteristic : | The isoelectric point is 9.1. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ] |
Official Symbol : | IL12RB2 |
Synonyms : | IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; interleukin-12 receptor subunit beta-2 |
Gene ID : | 3595 |
mRNA Refseq : | NM_001258214.1 |
Protein Refseq : | NP_001245143.1 |
UniProt ID : | Q99665 |
Products Types
◆ Recombinant Protein | ||
IL12RB2-3230H | Recombinant Human IL12RB2 Protein, His-tagged | +Inquiry |
IL12RB2-214H | Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL12RB2-9483H | Active Recombinant Human IL12RB2 Protein, Fc/His-tagged | +Inquiry |
IL12RB2-3885H | Recombinant Human IL12RB2 protein, His-tagged | +Inquiry |
IL12RB2-73H | Recombinant Human IL12RB2 protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL12RB2-2142MCL | Recombinant Mouse IL12RB2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewGood for receptor binding studies.
Consistent in bioactivity.
Suitable for flow cytometry.
Q&As (10)
Ask a questionCRISPR/Cas9 gene tagging tracks IL12RB2 localization dynamically.
Crosslinking and immunoprecipitation study IL12RB2 dimerization.
ChIP-seq identifies genes under IL12RB2's regulation.
Quantitative RT-PCR validates IL12RB2's impact on gene expression.
Functional assays validate IL12RB2's role in signaling pathways.
Flow cytometry quantifies IL12RB2 expression on specific cell types.
Confocal microscopy visualizes IL12RB2 distribution in cells.
siRNA knockdown reveals IL12RB2's functional significance.
Co-immunoprecipitation unveils IL12RB2's protein interactions.
Co-immunoprecipitation and ELISA assay cytokine interactions with IL12RB2.
Ask a Question for All IL12RB2 Products
Required fields are marked with *
My Review for All IL12RB2 Products
Required fields are marked with *
Inquiry Basket