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Recombinant Human IL12RB2 protein, His & GST-tagged
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Cat.No. : | IL12RB2-1465H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL12RB2 aa. (Tyr559~Gln647 (Accession # Q99665)) fused with N-terminal His & GST tag was produced in E. coli cells. |
Description : | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 42.6kDa. |
Protein length : | Tyr559~Gln647 (Accession # Q99665) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method). |
Purity : | >95% |
Characteristic : | The isoelectric point is 9.1. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
SDS-PAGE : |
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Gene Name : | IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ] |
Official Symbol : | IL12RB2 |
Synonyms : | IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; interleukin-12 receptor subunit beta-2 |
Gene ID : | 3595 |
mRNA Refseq : | NM_001258214.1 |
Protein Refseq : | NP_001245143.1 |
UniProt ID : | Q99665 |
◆ Recombinant Protein
IL12RB2-3885H | Recombinant Human IL12RB2 protein, His-tagged | +Inquiry |
IL12RB2-73H | Recombinant Human IL12RB2 protein, Fc-tagged | +Inquiry |
IL12RB2-9483H | Recombinant Human IL12RB2 Protein, Fc/His-tagged | +Inquiry |
IL12RB2-214H | Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL12RB2-3230H | Recombinant Human IL12RB2 Protein, His-tagged | +Inquiry |
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◆ Lysates
IL12RB2-2142MCL | Recombinant Mouse IL12RB2 cell lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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