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Recombinant Human IL12RB2 protein, Fc-tagged

Cat.No. : IL12RB2-73H
Product Overview : Recombinant Human IL12RB2 protein with Fc-tag was expressed in HEK293.
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Description : The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Source : HEK293
Species : Human
Tag : Fc
Molecular Mass : The protein has a calculated MW of 95 kDa.
AA Sequence : KIDACKRGDVTVKPSHVILLGSTVN ITCSLKPRQGCFHYSRRNKLILYKF DRRINFHHGHSLNSQVTGLPLGTTL FVCKLACINSDEIQICGAEIFVGVA PEQPQNLSCIQKGEQGTVACTWERG RDTHLYTEYTLQLSGPKNLTWQKQC KDIYCDYLDFGINLTPESPESNFTA KVTAVNSLGSSSSLPSTFTFLDIVR PLPPWDIRIKFQKASVSRCTLYWRD EGLVLLNRLRYRPSNSRLWNMVNVT KAKGRHDLLDLKPFTEYEFQISSKL HLYKGSWSDWSESLRAQTPEEEPTG MLDVWYMKRHIDYSRQQISLFWKNL SVSEARGKILHYQVTLQELTGGKAM TQNITGHTSWTTVIPRTGNWAVAVS AANSKGSSLPTRINIMNLCEAGLLA PRQVSANSEGMDNILVTWQPPRKDP SAVQEYVVEWRELHPGGDTQVPLNW LRSRPYNVSALISENIKSYICYEIR VYALSGDQGGCSSILGNSKHKAPLS GPHINAITEEKGSILISWNSIPVQE QMGCLLHYRIYWKERDSNSQPQLCE IPYRVSQNSHPINSLQPRVTYVLWM TALTAAGESSHGNEREFCLQGKANL EVLFQGPEPKSSDKTHTCPPCPAPE LLGGPSVFLFPPKPKDTLMISRTPE VTCVVVDVSHEDPEVKFNWYVDGVE VHNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCKVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKGFYPSDIAVEWES NGQPENNYKTTPPVLDSDGSFFLYS KLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGK
Purity : >80%, by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.4 mg/ml
Storage Buffer : Supplied as a 0.2 μm filtered solution in PBS, pH7.4.
Gene Name : IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ]
Official Symbol : IL12RB2
Synonyms : IL12RB2; interleukin 12 receptor subunit beta 2; interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain
Gene ID : 3595
mRNA Refseq : NM_001559
Protein Refseq : NP_001550
MIM : 601642
UniProt ID : Q2M3V3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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