Recombinant Human IL12RB2 Protein, His-tagged
|Product Overview :||Recombinant Human IL12RB2 protein with a His tag was expressed in HEK293.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.|
|Molecular Mass :||68.5 kDa|
|AA Sequence :||KIDACKRGDVTVKPSHVILLGSTVN ITCSLKPRQGCFHYSRRNKLILYKF DRRINFHHGHSLNSQVTGLPLGTTL FVCKLACINSDEIQICGAEIFVGVA PEQPQNLSCIQKGEQGTVACTWERG RDTHLYTEYTLQLSGPKNLTWQKQC KDIYCDYLDFGINLTPESPESNFTA KVTAVNSLGSSSSLPSTFTFLDIVR PLPPWDIRIKFQKASVSRCTLYWRD EGLVLLNRLRYRPSNSRLWNMVNVT KAKGRHDLLDLKPFTEYEFQISSKL HLYKGSWSDWSESLRAQTPEEEPTG MLDVWYMKRHIDYSRQQISLFWKNL SVSEARGKILHYQVTLQELTGGKAM TQNITGHTSWTTVIPRTGNWAVAVS AANSKGSSLPTRINIMNLCEAGLLA PRQVSANSEGMDNILVTWQPPRKDP SAVQEYVVEWRELHPGGDTQVPLNW LRSRPYNVSALISENIKSYICYEIR VYALSGDQGGCSSILGNSKHKAPLS GPHINAITEEKGSILISWNSIPVQE QMGCLLHYRIYWKERDSNSQPQLCE IPYRVSQNSHPINSLQPRVTYVLWM TALTAAGESSHGNEREFCLQGKANH HHHHH|
|Purity :||> 80% by SDS-PAGE|
|Storage :||Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Concentration :||0.85 mg/mL|
|Storage Buffer :||Supplied as a 0.2 μm filtered solution in PBS, pH7.4.|
|Gene Name :||IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ]|
|Official Symbol :||IL12RB2|
|Synonyms :||IL12RB2; interleukin 12 receptor subunit beta 2; interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain|
|Gene ID :||3595|
|mRNA Refseq :||NM_001559|
|Protein Refseq :||NP_001550|
|UniProt ID :||Q99665|
|◆ Recombinant Protein|
|IL12RB2-73H||Recombinant Human IL12RB2 protein, Fc-tagged||+Inquiry|
|IL12RB2-214H||Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged||+Inquiry|
|IL12RB2-3885H||Recombinant Human IL12RB2 protein, His-tagged||+Inquiry|
|IL12RB2-9483H||Recombinant Human IL12RB2 Protein, Fc/His-tagged||+Inquiry|
|IL12RB2-3233H||Recombinant Human IL12RB2 protein, His-tagged||+Inquiry|
|IL12RB2-2142MCL||Recombinant Mouse IL12RB2 cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
CRISPR/Cas9 gene tagging tracks IL12RB2 localization dynamically.
Crosslinking and immunoprecipitation study IL12RB2 dimerization.
ChIP-seq identifies genes under IL12RB2's regulation.
Quantitative RT-PCR validates IL12RB2's impact on gene expression.
Functional assays validate IL12RB2's role in signaling pathways.
Flow cytometry quantifies IL12RB2 expression on specific cell types.
Confocal microscopy visualizes IL12RB2 distribution in cells.
siRNA knockdown reveals IL12RB2's functional significance.
Co-immunoprecipitation unveils IL12RB2's protein interactions.
Co-immunoprecipitation and ELISA assay cytokine interactions with IL12RB2.
Customer Reviews (3)Write a review
Good for receptor binding studies. -
Consistent in bioactivity. -
Suitable for flow cytometry. -
Ask a Question for All IL12RB2 Products
Required fields are marked with *
My Review for All IL12RB2 Products
Required fields are marked with *