ITGA4 Protein, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

ITGA4

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ITGA4

Official Full Name integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Background The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Synonyms ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D
    • Species :
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA4 & ITGB1-162H Recombinant Human ITGA4 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGA4 & ITGB7-163H Recombinant Human ITGA4 & ITGB7 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGA4-1541H Recombinant Human ITGA4 protein, His-tagged E.coli His
    Human ITGA4-161H Recombinant Human ITGA4 & ITGB1, Flag & His tagged Human Cell His
    Human ITGA4-4997H Recombinant Human ITGA4 Protein, GST-tagged Wheat Germ GST
    Human ITGA4-4998H Recombinant Human ITGA4 Protein Wheat Germ N/A
    Human ITGA4-5133HCL Recombinant Human ITGA4 293 Cell Lysate HEK293 N/A
    Mouse Itga4&Itgb1-347M Recombinant Mouse Itga4&Itgb1 CHO N/A
    Mouse Itga4-5665M Recombinant Mouse Integrin Alpha 4, His-tagged CHO His
    Mouse ITGA4-8350M Recombinant Mouse ITGA4 Protein Mammalian Cell His

    ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway FGF16; YWHAG; GNG5; G6PC; PPP2R2D; TLR4; PPP2R2B; COL27A1; SGK1; PRKAA2
    Focal adhesion PIK3R1; TESK2; IGF1RB; XIAP; PPP1CB; VAV1; MAPK4; PRKCB; IGF1R; CDC42L
    ECM-receptor interaction HMMR; COL11A2; VTNB; ITGA6B; LAMA2; COL4A4; ITGA10; THBS4A; COL1A1; FN1A
    Cell adhesion molecules (CAMs) NCAM2; CLDN16; CLDNK; HLA-A; HLA-DRB3; ITGA8; Siglec1; CLDN6; CLDN7A; MHC2DAB
    Hematopoietic cell lineage CD37; IL6; CD1D; IL5RA; CD3E; CD3D; Kitl; CD2; GP9; GYPA; HLA-DRB3
    Leukocyte transendothelial migration PLCG2; PTK2B; CDC42; CLDN6; VASP; ROCK1; AASS; MMP2; RAC2; PTK2
    Intestinal i CCR10; MHC2DEB; TNFSF13; TNFRSF13B; CXCR4B; CXCL12A; CXCL12; CXCR4A; HLA-DPA1; HLA-DMA
    ne network for IgA production CXCR4; CCL25; HLA-DMB; HLA-DRB5; BMA2; CCR10; HLA-DRB1; TGFB1A; CD28; LTBR
    Regulation of actin cytoskeleton ITGA2; WAS; ACTN2B; ARPC5L; ITGB7; SOS1; GNA12A; RRAS; PAK6B; TMSB
    Leishmaniasis PTPN6; ITGB1; RELA; CR1; TAB2; TGFB3; MARCKSL1; MAPK1; IRAK1; TRAF6
    Hypertrophic cardiomyopathy (HCM) DMD; CACNB2; ITGA10; TNNC1; ITGB6; TNF; CACNA2D1; CACNG7; TGFB3; TNNI3
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) LEF1; SGCD; SGCA; ITGB3; CTNNA3; AASS; EMD; CACNA2D1; SGCB; ITGA1
    Dilated cardiomyopathy MYL2; MYL3; CACNG4; TNF; CACNG1; LAMA2; PRKACA; SGCG; ADRB1; DAG1

    ITGA4 has several biochemical functions, for example, cell adhesion molecule binding, fibronectin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding GLYCAM1; CAML; CD226; SMAGP; ITGB7; ITGB3; PTBP3; SELL; NRXN2; NLGN2
    fibronectin binding LPA; ITGB1A; ITGB1; LRRC15; VEGFA; ITGB3; PLEKHA2; LACRT; HSD17B12; CTSS
    metal ion binding NCALDB; VDRB; MARCH6; CHSY1; NRP1; LHX1A; CYP2C39; ARL1; FAHD1; THAP3
    protein antigen binding EP300; KLRC2; H2-AB1; ITGA4; KLRD1
    protein binding NOP58; PSPC1; ZBTB24; E2F1; PDZD3; SOX10; NCALD; SCNM1; KLHL20; BIRC7

    ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.

    PXN; ITGB1; VCAM1; LYN; TGFB1I1; LPXN; ITGB1; FLNA

    Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
    Reindel, R; Baker, SC; et al. Integrins alpha 4 and alpha M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. PEDIATRIC RESEARCH 73:332-336(2013).

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