itga4
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  • Official Full Name
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
  • Background
  • The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
  • Synonyms
  • ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D
Cat.#:ITGA4 & ITGB1-162HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA4 & ITGB1 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGA4 & ITGB7-163HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA4 & ITGB7 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGA4-4997HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA4 Protein, GST-tagged
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Cat.#:ITGA4-4998HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA4 Protein
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Cat.#:ITGA4-1541HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA4 protein, His-tagged
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Cat.#:ITGA4-161HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA4 & ITGB1, Flag & His tagged
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Cat.#:Itga4&Itgb1-347MTag:
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse Itga4&Itgb1
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Cat.#:Itga4-5665MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Integrin Alpha 4, His-tagged
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Cat.#:ITGA4-8350MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGA4 Protein
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Cat.#:ITGA4-5133HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGA4 293 Cell Lysate
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Involved Pathway

ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
INS; HSP90AA1; PDGFC; IFNAR2; PPP2CA; COL24A1; HSP90AB1; SGK1; TCL1B1; IL3RA
Focal adhesion
THBS3A; ITGB3B; ACTB2; COL6A5; ITGA6B; ROCK1; MYL7; MYL12.2; PIK3R2; THBS4B
ECM-receptor interaction
ITGA8; COL27A1B; COL4A6; ITGA10; THBS3; COL6A5; GP6; LAMC2; HMMR; SDC1
Cell adhesion molecules (CAMs)
CLDN4; HLA-E; H2-Q10; HLA-DQA1; HLA-G; NFASC; PECAM1; CNTNAP2; CLDNF; BLA
Hematopoietic cell lineage
ITGA3; CD59; CD24; CD3G; CD1D; TNF; IL4; IL11; IL3; HLA-DRB5
Leukocyte transendothelial migration
RAP1B; NIPAL1; ITGA4; RAC1; ITGB1; PIK3CD; ROCK1; CLDN20; CLDN17; CLDN7
Intestinal i
CXCL12B; MHC2DEB; CD28; HLA-DQA1; CD86; IL-15RA; HLA-DQB1; Icosl; ITGA4; CD40
ne network for IgA production
HLA-DMA; BMA1; MHC2A; IL5; IL4; TNFSF13; CCL25; CD86; CCR9A; CCL27B
Regulation of actin cytoskeleton
MYL7; PFN1; ITGB1A; FGF7; FN1; PAK1; RAC3A; MSNA; ITGB2; ABI2B
Leishmaniasis
MAPK11; PTPN6; PTGS2; RELA; C3; IL12B; FCGR2C; CR1; MAPK12; ITGB2L
Hypertrophic cardiomyopathy (HCM)
MYH7; TGFB2; ITGA2; PRKAB2; ITGA1; ITGB5; CACNB2; ATP2A2; CACNA2D2; ITGB6
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
AASS; CACNG1; CACNA2D3; ITGA2; CTNNA2; CACNA2D1; ITGA3; DSC2; SGCA; CTNNA1
Dilated cardiomyopathy
ITGB5; CACNG2; ACTC1; TPM1; CACNG3; TTN; CACNG8; ADRB1; GNAS; PLN

Protein Function

ITGA4 has several biochemical functions, for example, cell adhesion molecule binding, fibronectin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein CADM1B; NLGN4Y; NLGN1; NLGN4X; NRXN1; PVRL4; SMAGP; NLGN2; PTBP3; NRXN3
Function fibronectin binding
Related Protein ITGA3; CTSL1; CCDC80; ITGA4; LPA; THBS1; LRRC15; SDC4; CTSS; FSTL3
Function metal ion binding
Related Protein AARS2; SMYD2A; PHC2A; ITGA7; PARN; ELMSAN1A; ADCY8; ITGA6; ALKBH6; PLA2G12B
Function protein antigen binding
Related Protein H2-AB1; ITGA4; KLRC2; KLRD1; EP300
Function protein binding
Related Protein CREB1; ZDHHC17; NOSTRIN; MTA1; ATOX1; RPAP1; FAM9B; THRAA; LAT2; TFG

Interacting Protein

ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.
PXN; ITGB1; VCAM1; LYN; TGFB1I1; LPXN; ITGB1; FLNA

ITGA4 Related Articles

Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
Reindel, R; Baker, SC; et al. Integrins alpha 4 and alpha M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. PEDIATRIC RESEARCH 73:332-336(2013).