| Description : |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
114.87 kDa |
| AA Sequence : |
MAWEARREPGPRRAAVRETVMLLLC LGVPTGRPYNVDTESALLYQGPHNT LFGYSVVLHSHGANRWLLVGAPTAN WLANASVINPGAIYRCRIGKNPGQT CEQLQLGSPNGEPCGKTCLEERDNQ WLGVTLSRQPGENGSIVTCGHRWKN IFYIKNENKLPTGGCYGVPPDLRTE LSKRIAPCYQDYVKKFGENFASCQA GISSFYTKDLIVMGAPGSSYWTGSL FVYNITTNKYKAFLDKQNQVKFGSY LGYSVGAGHFRSQHTTEVVGGAPQH EQIGKAYIFSIDEKELNILHEMKGK KLGSYFGASVCAVDLNADGFSDLLV GAPMQSTIREEGRVFVYINSGSGAV MNAMETNLVGSDKYAARFGESIVNL GDIDNDGFEDVAIGAPQEDDLQGAI YIYNGRADGISSTFSQRIEGLQISK SLSMFGQSISGQIDADNNGYVDVAV GAFRSDSAVLLRTRPVVIVDASLSH PESVNRTKFDCVENGWPSVCIDLTL CFSYKGKEVPGYIVLFYNMSLDVNR KAESPPRFYFSSNGTSDVITGSIQV SSREANCRTHQAFMRKDVRDILTPI QIEAAYHLGPHVISKRSTEEFPPLQ PILQQKKEKDIMKKTINFARFCAHE NCSADLQVSAKIGFLKPHENKTYLA VGSMKTLMLNVSLFNAGDDAYETTL HVKLPVGLYFIKILELEEKQINCEV TDNSGVVQLDCSIGYIYVDHLSRID ISFLLDVSSLSRAEEDLSITVHATC ENEEEMDNLKHSRVTVAIPLKYEVK LTVHGFVNPTSFVYGSNDENEPETC MVEKMNLTFHVINTGNSMAPNVSVE IMVPNSFSPQTDKLFNILDVQTTTG ECHFENYQRVCALEQQKSAMQTLKG IVQFLSKTDKRLLYCIKADPHCLNF LCNFGKMESGKEASVHIQLEGRPSI LEMDETSALKFEIRATGFPEPNPRV IELNKDENVAHVLLEGLHHQRPKRY FTIVIISSSLLLGLIVLLLISYVMW KAGFFKRQYKSILQEENRRDSWSYI NSKSNDDTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
