jak3
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  • Official Full Name
  • Janus kinase 3
  • Background
  • Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
  • Synonyms
  • JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK
Cat.#:JAK3-1672MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse JAK3 Protein (818-1100 aa), His-tagged
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Cat.#:JAK3-1887HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 3, GST-tagged
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Cat.#:JAK3-252HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK3 Protein, His-tagged
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Cat.#:Jak3-253MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jak3 Protein, His-tagged
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Cat.#:JAK3-2657HTag:His/GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Janus Kinase 3, GST-His
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Cat.#:JAK3-27631THTag:
Source (Host):Species:Human
Product nameRecombinant Human JAK3
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Cat.#:JAK3-32HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAK3 protein, MYC/DDK-tagged
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Cat.#:JAK3-337HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Janus Kinase 3, GST-tagged, Active
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Cat.#:JAK3-466HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAK3
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Cat.#:JAK3-8410MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse JAK3 Protein
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Cat.#:JAK3-6554CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JAK3
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Cat.#:JAK3-5106HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human JAK3 293 Cell Lysate
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Cat.#:Kit-1608Tag:
Source (Host):Species:
Product nameJAK3 Activity Assay Kit
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Involved Pathway

JAK3 involved in several pathways and played different roles in them. We selected most pathways JAK3 participated on our site, such as ARMS-mediated activation, Axon guidance, CD40/CD40L signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
CSK; AKAP9; RASGRP4; PSMD5; PAQR3A; FGF10B; DUSP7; PTPRA; DUSP1; DLG4
Axon guidance
KBTBD7; EFNA3B; SPTB; PLXNA1; RND1; NFATC4; EFNA4; CLTB; FGFR1B; MYL12B
CD40/CD40L signaling
MYC; JAK3; TDP2
Chemokine signaling pathway
GM10591; HCK; NRAS; ROCK1; GRB2; PLCB4; NCF1; PLCB1; PRKCZ; GRK6
Cytokine Signaling in Immune system
PEBP1; CASPBL; BST2; CSF2RB; IFITM2; RASGRP1; PEA15; KPNA3; EIF4A2; EIF4E3
DAP12 interactions
SPRED1; FGF10B; MARK3; ADRBK1; JAK1; TRAT1; PRKAR1AA; NRG2A; PTPRA; NRG4
DAP12 signaling
FGF8B; DUSP9; AGO2; AGO1; FRS3; RASGRP1; NEFLB; DUSP7; SPNA1; SPTBN2
Developmental Biology
KIF4; EFNA2A; SIAH2; CD24; TRIO; NRTN; INSM1A; CDK19; HFE2; JAK1

Protein Function

JAK3 has several biochemical functions, for example, ATP binding, hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK3 itself. We selected most functions JAK3 had, and list some proteins which have the same functions with JAK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CSNK1E; ATP11A; NAIP6; FYNB; TAP1; UBE2C; PI4KA; PSMC5; STK25A; YME1L1B
Function hormone receptor binding
Related Protein JAK3; JAK2A; JAK2B; SRC; TNK2B; TNK2; TNK1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein CSK; EIF2AK2; SYK; Fert2; TNK1; JAK3; BAZ1B; MATK; FYNB; BLK
Function protein binding
Related Protein PPP1R15B; ATP4B; SIK2; NRBP1; PER2; TGIF2LY; TRMT2B; PPP2R2B; POLR1D; NOS1
Function protein phosphatase binding
Related Protein MET; CDH5; MAP2K7; ERBB2; FLT4; JUP; PIK3R2; CDKN1B; ANAPC7; KAT2A
Function protein tyrosine kinase activity
Related Protein AXL; EPHA4B; MATK; EGFRA; RET; WEE1; DYRK2; YES1; TESK2; MAP3K9

Interacting Protein

JAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK3.
TCP1; CCT6A; CCT8; CCT4; NAP1L1; MAGED2; LNX1; saicar; NFATC1; PKM; ERBB3

JAK3 Related Articles

Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
Bauer, SM; Gehringer, M; et al. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. ANALYTICAL METHODS 6:8817-8822(2014).

JAK3 Related Gene Family

TGF