Active Recombinant Human JAK3 Protein, His tagged

• Cat.No.: JAK3-04H
• Product Overview: Active recombinant human N-terminal His-tagged JAK3 kinase domain (811-1124 aa) expressed in insect cells (Sf9).

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 811-1124 aa
• Description: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
• Form: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 3 mM DTT, 20% glycerol, and 200 mM imidazole
• Molecular Mass: 37 kDa
• Purity: ≥90% estimated by SDS-PAGE
• Storage: At -80 centigrade, Stability ≥ 6 months
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: JAK3 Janus kinase 3 [ Homo sapiens (human) ]
• Official Symbol: JAK3
• Synonyms: JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK
• Gene ID: 3718
• mRNA Refseq: NM_000215
• Protein Refseq: NP_000206
• MIM: 600173
• UniProt ID: P52333