Recombinant Human JAK3 Protein, His-tagged JAK3-252H

Specification
Gene Information
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Cat.No.:	JAK3-252H
Product Overview:	Recombinant Human JAK3(Trp716~Asp967) fused with His tag at N-terminal was expressed in E. coli.
Description:	The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Source:	E. coli
Species:	Human
Tag :	His
Form:	20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass:	32.5kDa
Protein length:	Trp716~Asp967
Endotoxin:	<1.0EU per 1µg (determined by the LAL method)
Purity:	> 98%
Applications:	Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein.
Stability:	The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage:	Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution:	Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

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Gene Name:	JAK3 Janus kinase 3 [ Homo sapiens ]
Official Symbol:	JAK3
Synonyms:	JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK;
Gene ID:	3718
mRNA Refseq:	NM_000215
Protein Refseq:	NP_000206
MIM:	600173
UniProt ID:	P52333