Recombinant Human Janus Kinase 3, GST-tagged, Active
Cat.No. : | JAK3-337H |
Product Overview : | Recombinant human JAK3 (781-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 64 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | JAK3-337H |
Description : | JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 781-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | JAK3 Janus kinase 3 [ Homo sapiens ] |
Synonyms : | JAK3; Janus kinase 3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC 2.7.10.2 |
Gene ID : | 3718 |
mRNA Refseq : | NM_000215 |
Protein Refseq : | NP_000206 |
MIM : | 600173 |
UniProt ID : | P52333 |
Chromosome Location : | 19p13.1 |
Pathway : | Chemokine signaling pathway; Jak-STAT signaling pathway; Primary immunodeficiency |
Function : | ATP binding; Janus kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity |
Products Types
◆ Recombinant Protein | ||
JAK3-3185H | Recombinant Human JAK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
JAK3-467H | Active Recombinant Human JAK3 Protein, His-tagged | +Inquiry |
JAK3-252H | Recombinant Human JAK3 Protein, His-tagged | +Inquiry |
JAK3-4669M | Recombinant Mouse JAK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Jak3-3628M | Recombinant Mouse Jak3 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
JAK3-5106HCL | Recombinant Human JAK3 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1608 | JAK3 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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