MBP
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Official Full Name
myelin basic protein
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Overview
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the shiverer and myelin deficient phenotypes in mouse. [provided by RefSeq, Jul 2008] -
Synonyms
MBP; myelin basic protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp; shiverer; myelin deficient; myelin A1 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Cattle
- Chicken
- E.coli
- Human
- Mouse
- Pan-species (General)
- Pig
- Rabbit
- Bovine Central Nervous System Tissue
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Brain
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Mouse Central Nervous System
- Pig Brain
- porcine brain
- Swine
- Biotin
- C
- GFP
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- MBP
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- MBP Related Articles
MBP involved in several pathways and played different roles in them. We selected most pathways MBP participated on our site, such as Glial Cell Differentiation, MAPK Cascade, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glial Cell Differentiation | MBP;TPPP;GAP43;CNP;PLP1 |
MAPK Cascade | MAP3K2;MAP2;MBPB;MBP |
Neural Crest Differentiation | PMP22;FOXD3;HOXA1;PRTG;HEY2;OLIG2;LHX1;OLIG1;TFAP2A |
Spinal Cord Injury | LGALS3;PTPRZ1;NOX4;TNFSF13B;OMG;RTN4;LILRB3;RGMA;RTN4R |
MBP has several biochemical functions, for example, protease binding, protein binding, structural constituent of myelin sheath. Some of the functions are cooperated with other proteins, some of the functions could acted by MBP itself. We selected most functions MBP had, and list some proteins which have the same functions with MBP. You can find most of the proteins on our site.
Function | Related Protein |
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protease binding | PEO1;CHL1;COMP;DPP4;TNFAIP3;HSPD1;RFFL;Casp3;SERPINB9 |
protein binding | PGK1;PTPN23;TBC1D22B;EFHA1;PDP1;ERCC1;KLK5;PKD1L3;KIAA1279 |
structural constituent of myelin sheath | NCMAP;MBP;PLP1;MAL;MBPB;MOBP |
MBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBP here. Most of them are supplied by our site. Hope this information will be useful for your research of MBP.
CTDSP1; q8iin1_plaf7; PBK; PRMT10; HLA-DRB1; RXRB; ATXN1; ATN1; PDGFRL; APTX; APP; HLA-DRB1; HLA-DMA
- Q&As
- Reviews
Q&As (7)
Ask a questionThe MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.
MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.
In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.
Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.
Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.
Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.
MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.
Customer Reviews (3)
Write a reviewProduct exactly as described.
Worked well in ELISA.
Excellent customer support, helpful.
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