• Official Full Name
  • prolyl 4-hydroxylase, beta polypeptide
  • Background
  • This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to;the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this;enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase;containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other;known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a;concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of;S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein;complex.
  • Synonyms
  • P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB, His tagged
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse P4hb, His tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse P4hb protein, His & GST-tagged
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse P4HB Protein, His-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat P4hb protein, His & GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P4HB Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P4HB
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish P4HB
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB cell lysate
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse P4HB cell lysate

Involved Pathway

P4HB involved in several pathways and played different roles in them. We selected most pathways P4HB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum

Protein Function

P4HB has several biochemical functions, for example, endopeptidase activity, enzyme binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HB itself. We selected most functions P4HB had, and list some proteins which have the same functions with P4HB. You can find most of the proteins on our site.
Related Protein
Function endopeptidase activity
Related Protein FAP; F9; P4HB; MMP3; PSMA6B; KLK1B8; PSEN2; TPP1; KLK1B16; HTRA4
Function enzyme binding
Related Protein TBP; HDAC2; MST1R; TARBP2; SCN5A; SLPI; ANK1; LUC7L2; SNX12; TOP2B
Function integrin binding
Related Protein ACTN2; COL5A1; Tcam1; ITGB5; MMP14; FAP; TSPAN4; DST; ITGB1BP2; ANGPTL3
Function poly(A) RNA binding
Related Protein RPS25; RAVER1; CLK3; MEPCE; MAK16; JUN; DHX9; MRPL39; SECISBP2; ZFML
Function contributes_to procollagen-proline 4-dioxygenase activity
Related Protein P4HB
Function protein binding
Related Protein KRT16; PFDN5; ABI3; SYCE1; SP3; MAB21L2; LARP4B; RBBP5; NMB; UBR2
Function protein disulfide isomerase activity
Related Protein PDIA6; ITGB3; TXNDC11; ERP44; PIGK; ERO1L; TMX1; TXNDC5; PDIA5; GLRX2
Function protein heterodimerization activity
Related Protein HYPM; TLX1; JAM2A; DDX1; MEF2A; ARNT; UGT1A4; HER1; TCF4; FZD1

Interacting Protein

P4HB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HB here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HB.
ERO1L; heparin; GABARAPL2; TAP1; env; MAPT; MAPT; PRDX4; PDIA3