p4hb
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  • Official Full Name
  • prolyl 4-hydroxylase, beta polypeptide
  • Background
  • This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to;the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this;enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase;containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other;known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a;concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of;S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein;complex.
  • Synonyms
  • P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote
Cat.#:P4HB-1478HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human P4HB Protein (18-508 aa), His-tagged
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Cat.#:P4HB-2042CTag:His
Source (Host):E. coliSpecies:Cricetulus Griseus
Product nameRecombinant Cricetulus Griseus P4HB Protein (20-509 aa), His-tagged
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Cat.#:P4HB-116HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB, MYC/DDK-tagged
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Cat.#:P4HB-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB protein, His-tagged
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Cat.#:P4HB-27008THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
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Cat.#:P4HB-30545THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
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Cat.#:P4HB-310HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB, His tagged
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Cat.#:P4hb-1130MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse P4hb, His tagged
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Cat.#:P4hb-1450MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse P4hb protein, His & GST-tagged
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Cat.#:P4HB-33MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse P4HB Protein, His-tagged
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Cat.#:P4hb-1451RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat P4hb protein, His & GST-tagged
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Cat.#:P4HB-4242RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P4HB Protein
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Cat.#:P4HB-4209CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P4HB
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Cat.#:P4HB-12543ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish P4HB
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Cat.#:P4HB-2760HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HB, His-tagged
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Cat.#:P4HB-2764HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HB cell lysate
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Cat.#:P4HB-2121MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse P4HB cell lysate
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Involved Pathway

P4HB involved in several pathways and played different roles in them. We selected most pathways P4HB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
UBE2G1B; ERO1L; EIF2S1B; LMAN1L; SSR4; CAPN2B; AMFR; DNAJA1; BCL2A; BAXA

Protein Function

P4HB has several biochemical functions, for example, endopeptidase activity, enzyme binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HB itself. We selected most functions P4HB had, and list some proteins which have the same functions with P4HB. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein CTSH; KLK1B26; NCSTN; AP1S2; PSMB1; TMEM59; REN2; FURIN; ADAM10; PSMB8F
Function enzyme binding
Related Protein CNTNAP2; PTPLAD1; WWOX; HDAC6; RFC5; MLEC; NR5A1; RARA; PRKDC; PTPLAD2
Function integrin binding
Related Protein ADAMTS5; CYR61; WISP2; FBLN1; GPNMB; CD151; NISCH; P4HB; ITGA5; PPAP2B
Function poly(A) RNA binding
Related Protein FAM133B; KIAA1429; MRPL44; MYO18A; EBI3; ZFP36L1; DDX18; FAM120B; HNRNPA0; NOC4L
Function contributes_to procollagen-proline 4-dioxygenase activity
Related Protein P4HB
Function protein binding
Related Protein TCF25; CALR; ARHGEF2; PCGF5; CALCR; DRG2; MAP4K5; KIAA0368; CDT1; DLC1
Function protein disulfide isomerase activity
Related Protein PDIA4; TMX4; ITGB3; TXNDC11; PDIA6; QSOX1; PDIP5; GLRX2; PDIA5; ERP44
Function protein heterodimerization activity
Related Protein TYRO3; SOX14; HMG20A; ABCG1; RRAGD; KATNB1; GABPB1; STX1A; SIM2; HIST1H2BO

Interacting Protein

P4HB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HB here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HB.
ERO1L; heparin; GABARAPL2; TAP1; env; MAPT; MAPT; PRDX4; PDIA3