pik3ca
Share
  • Official Full Name
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • Background
  • Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
  • Synonyms
  • PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3K; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein
Cat.#:PIK3CA/PIK3R1-389HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, His-tagged, Active
+Inquiry
Cat.#:PIK3CA/PIK3R1-631HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, FLAG-tagged
+Inquiry
Cat.#:PIK3CA/PIK3R1-641HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1
+Inquiry
Cat.#:Pik3ca/PIK3R1-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse, Human
Product nameRecombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
+Inquiry
Cat.#:PIK3CA-1864BTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, GST-tagged
+Inquiry
Cat.#:PIK3CA&PIK3R1-150HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA(E545K)/PIK3R1 protein, His-tagged, Active
+Inquiry
Cat.#:PIK3CA&PIK3R1-151HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA(N345K)/PIK3R1 protein, His-tagged, Active
+Inquiry
Cat.#:PIK3CA&PIK3R1-152HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA(E542K)/PIK3R1 protein, His-tagged, Active
+Inquiry
Cat.#:PIK3CA&PIK3R1-153HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1 protein, GST-tagged, Active
+Inquiry
Cat.#:PIK3CA&PIK3R1-154HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1 protein, His-tagged, Active
+Inquiry
Cat.#:PIK3CA&PIK3R3-152HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R3 protein, His-tagged, Active
+Inquiry
Cat.#:PIK3CA-1894HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PI3 kinase (p110α/p85α) protein, GST-tagged
+Inquiry
Cat.#:PIK3CA-29687THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CA, His-tagged
+Inquiry
Cat.#:PIK3CA-331HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PIK3CA
+Inquiry
Cat.#:PIK3CA-70HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PIK3CA protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:PIK3CA-12801MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3CA Protein
+Inquiry
Cat.#:PIK3CA-3432RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3CA Protein, His-tagged
+Inquiry
Cat.#:PIK3CA-208BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3CA
+Inquiry
Cat.#:PIK3CA-1228CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CA
+Inquiry
Cat.#:PIK3CA-610BTag:His
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, His-tagged
+Inquiry
Cat.#:PIK3CA-1078HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Catalytic, Alpha Polypeptide, His-tagged
+Inquiry
Cat.#:Pik3ca-1079HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Phosphatidylinositol 3-Kinase, Catalytic, Alpha Polypeptide, His-tagged
+Inquiry
Cat.#:PIK3CA-3189HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3CA 293 Cell Lysate
+Inquiry

Involved Pathway

PIK3CA involved in several pathways and played different roles in them. We selected most pathways PIK3CA participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
MTMR4; PI4KA; PIK3C2B; PLCB1; MTMR7A; PLCZ1; PIP5K1BA; PLCD1; PLCB3; INPP5L
ErbB signaling pathway
PAK6; RPS6KB2; GRB2A; PAK6B; STAT5B; BAD; MAP2K2B; MAPK8; NRG2B; EGFRA
Ras signaling pathway
PLD1; GAB2; GNG10; SHC1; NRAS; GNB3; PLA2G12A; FGF13; SHC2; CALM3
Rap signaling pathway
KIT; Fgf15; CALM4; VASP; HRAS; RAPGEF6; PRKCZ; PIK3R1; DOCK4; FARP2
cGMP-PKG signaling pathway
ATP2A3; CREB5; AGTR1B; PIK3R5; VDAC1; CALM4; ATP1A2; ATP2A1; PIK3CA; KCNMB4
cAMP signaling pathway
NPY1R; SLC9A1; RAP1B; PRKACA; PDE4B; PAK1; GRIA2; CAMK2G; VIPR2; CNGA3
Chemokine signaling pathway
VAV1; RAC2; GM2506; ARRB1; CCL14; AMCF-II; CDC42; CRK; GNG4; PF4V1
HIF- signaling pathway
PLCG1; CAMK2D; GAPDH; AKT1; EIF4E2; HIF1A; GM5506; HK1; VHL; IGF1
FoxO signaling pathway
GABARAPA; ATM; PRKAG2A; G6PCA.1; CDKN2D; MAPK12; SGK3; STK11; FOXO3B; MAP2K2A
Phosphatidylinositol signaling system
PRKCBA; PIP4K2C; PIK3C2A; PIP5K1AB; PRKCA; PIK3R1; CALM2; CALM1B; PIP4K2B; PPIP5K1
Sphingolipid signaling pathway
MAPK10; SMPD2; CERS2; CERS5; MAPK12; ASAH1; PIK3CD; MAPK11; GAB2; GNA12
Phospholipase D signaling pathway
AGPAT5; INS2; PDGFC; GAB1; FYN; TSC2; PPAP2B; GRM6; INS; PDGFB
mTOR signaling pathway
EIF4BB; RPS6KA3A; CAB39; RPS6KA1; PIK3R1; PRKAA1; RICTOR; EIF4E1B; DEPDC6; PRKCG
PIK-Akt signaling pathway
ITGAV; Reln; GNG13; NFKB1; PKN2; FGFR1; INS2; GNG5; FGF21; PPP2R5C
AMPK signaling pathway
PPP2R2B; LIPE; PFKFB3; AKT1; TSC2; PRKAB1; RAB2A; EIF4EBP1; CREB3L2; STRADA
Apoptosis
PPP3CCA; BIRC5A; PANK1A; JUN; TNFRSF10D; BADB; DSP; BAXB; DYNLL2; CAPN1B
Adrenergic signaling in cardiomyocytes
CREB5; CALM1; ADCY1A; CACNA1D; ATP1B2; PRKACBB; ATP1A3A; PPP2R2B; AGTR1; PPP1CAA
VEGF signaling pathway
RAC1; PIK3CD; KRAS; PTK2; HRASB; SRC; RAC3; PPP3CC; MAPK12A; MAP2K2
Osteoclast differentiation
NCF1; NCF2; AKT1; ACP5; IFNB1; TEC; CYBB; SOCS3; IFNGR2; RELB
Focal adhesion
MYL2B; RAF1A; VEGFB; RAP1A; HGF; LAMB1; GSK3B; BCAR1; TNR; IBSP
Signaling pathways regulating pluripotency of stem cells
INHBA; ONECUT1; AXIN1; SETDB1; IGF1; HNF1A; PCGF1; PIK3R5; KLF4; WNT4
Platelet activation
MAPK3; MYLK4; MYLK; F2R; GP1BB; ROCK2; GNAQ; PLA2G4D; LYN; F2RL3
Toll-like receptor signaling pathway
MAP3K7; RIPK1L; MAPK12A; MAP2K1; IRF7; PIK3R3; FADD; RAC1A; MAPK14B; MAP2K4B
Jak-STAT signaling pathway
IL12BA; LEPR; EP300; PTPN2; STAM; LEPB; CNTF; IFNAR1; IFNPHI1; IFNK
Natural killer cell mediated cytotoxicity
RAC3; FCGR3A; IFNA1; LAT; IFNAR2; NCR1; IFNA5; SH2D1A; ULBP3; MAP2K2
T cell receptor signaling pathway
CBL; VAV3; FYN; NFATC3; MAPK12; MAP2K7; PIK3R1; HRAS; LCP2; DBNLB
B cell receptor signaling pathway
PDPK1A; HDAC5; RAC3; VAV3; BLK; ARPC1B; CDK7; PPP3CA; NFATC2; VAV1
Fc epsilon RI signaling pathway
MAPK10; NRAS; PIK3R3; LCP2; RAC3; FYN; PIK3CB; PIK3R5; MAP2K4; PDPK1
Fc gamma R-mediated phagocytosis
WAS; PIP5K1B; PLD1; RPS6KB1; DOCK2; PLA2G6; AKT1; WASF1; LIMK2; PIK3CB
TNF signaling pathway
NFKBIA; CXCL10; CXCL5; IKBKG; MAPK1; MAPK10; NFKB1; BIRC3; Casp3; RPS6KA4
Leukocyte transendothelial migration
ITGB2L; PIK3CG; MMP2; CLDN9; MYL5; CLDN3; MYL12B; AASS; RAP1B; PIK3R1
Neurotrophin signaling pathway
NFKBIE; NFKBIA; ZFP110; AKT1; MAPK12; CAMK2A; MAP2K1; PLCG1; SH2B3; NGF
Cholinergic synapse
GNG5; PRKACG; CHAT; KCNJ6; KCNQ1; GNB4; CHRM5; KRAS; GNG2; KCNQ4
Inflammatory mediator regulation of TRP channels
HRH1; PRKCB; CYP2C70; CYP2C39; PRKCA; MAPK11; ALOX12; PLCG1; PPP1CA; IL1B
Regulation of actin cytoskeleton
PFN3; ARPC5A; WASB; PDGFAA; SCINLA; FGD1; FGF17; HRAS; FGFR1; ARPC5L
Insulin signaling pathway
PRKACAB; PPP1CA; G6PC; SHC4; FASN; EIF4E1B; INPPL1A; PHKB; PRKAB2; G6PC2
Progesterone-mediated oocyte maturation
CDC23; AKT2L; ANAPC7; PIK3R3; GNAI3; MAPK8B; CCNA1; MAPK8A; GNAI2A; RAF1
Estrogen signaling pathway
FKBP4; MAP2K1; GNAS; CREB3L2; ITPR3; ESR2; KCNJ6; SHC4; PRKACG; PIK3R5
Prolactin signaling pathway
RELA; INS; SOS1; MAPK11; PRL; MAP2K2; NRAS; CCND2; SHC4; ESR2
Thyroid hormone signaling pathway
PFKP; FOXO1; GATA4; NOTCH2; RXRA; ATP1B3; MED12; PIK3R3; SLCO1C1; SRC
Oxytocin signaling pathway
CCND1; HRAS; GNAI1; CALML5; OXT; CD38; MAPK3; RYR3; PRKAB2; PLA2G4F
Regulation of lipolysis in adipocytes
IRS4; PRKACA; PRKG2; INS; GNAI3; LIPE; PTGS2; IRS1; PTGER3; INS1
Type II diabetes mellitus
CACNA1G; PIK3CG; MAPK8; PRKCD; HK3; PIK3R1; SOCS3; INS1; IRS2; SOCS4
Insulin resistance
MAPK9; PPARGC1A; CREB3L3A; INSB; GSK3B; SLC27A2; G6PCA.2; PRKCE; PCK2; PPP1CAA
Non-alcoholic fatty liver disease (NAFLD)
LEPR; BID; INSR; NDUFS6; UQCRFS1; UQCR10; DDIT3; IKBKB; NDUFB2; SOCS3
Aldosterone-regulated sodium reabsorption
ATP1B4; SGK1; KRAS; INS; ALPHA-ENAC; PIK3R2; PIK3CA; ATP1A4; PIK3CD; ATP1A3
Carbohydrate digestion and absorption
ATP1A4; ATP1A3; PIK3R3; PRKCB; G6PC2; G6PC3; AMY1B; ATP1A2; FXYD2; SLC2A5
Bacterial invasion of epithelial cells
PIK3CA; CTNNA2; CBL; ELMO1; ARPC2; PIK3R1; CAV1; GAB1; PIK3R5; DNM3
Chagas disease (American trypanosomiasis)
PPP2R1B; GNAS; PPP2R2A; ACE; NFKBIA; PPP2R2D; CD3E; MAP2K4; PPP2CA; TICAM1
Toxoplasmosis
LAMA4; TNFRSF1A; IRAK4; LAMC2; MAP2K6; NFKB1; GNAI2; HLA-DQB1; BIRC8; HSPA1A
Amoebiasis
SERPINB13; C9; IL1B; C8A; PIK3CB; PLCB1; TGFB3; PIK3CA; CD1d1; LAMA3
Hepatitis C
CLDN10; RNASEL; EIF2AK2; TRADD; NR1H3; MAPK13; CLDN9; CLDN2; LDLR; OAS1A
Hepatitis B
PTK2B; IFNA10; MAPK8; GRB2; CCNA1; CASP8; BAX; YWHAZ; TGFB2; IKBKE
Measles
PIK3CD; IFNGR2; CCNE1; FCGR2B; IFNA17; IL2RA; EIF2AK2; FAS; OAS2; CBLB
Influenza A
IFNB; MAPK3; ACTB; TNFRSF10A; PIK3R1; MYD88; IL1A; TLR3; HLA-DRB4; IL6
HTLV-I infection
BUB3; FOSL1; PDGFB; LTBR; NFATC1; CDC23; ETS2; CDC20; RB1; TNFRSF13C
Epstein-Barr virus infection
PSMC3; MAP2K4; TRP53; SNW1; MAP2K6; TAB1; EIF2AK1; PSMD7; MAP2K3; POLR3GL
Pathways in cancer
FLT3; PTCH1; FZD1; AGTR1B; FASLG; STK4; BRCA2; WNT2; EGLN1; TCEB1
Viral carcinogenesis
IRF7; HDAC2; PIK3R2; GTF2H4; PIK3R1; GTF2A1L; HDAC9; HLA-G; TBPL2; CCNA1
Proteoglycans in cancer
MTOR; EZR; SDC4; WNT9B; FASLG; FLNC; FZD9; SLC9A1; TWIST1; MRAS
MicroRNAs in cancer
BMF; HMGA2; NOTCH3; BCL2; TP53; SHC1; FZD3; DNMT1; PDGFRA; RPTOR
Colorectal cancer
TRP53; MAPK10; ARAF; TGFB2; TGFB1; TCF7; TGFBR1; TP53; APPL1; MSH2
Renal cell carcinoma
EGLN2; MAP2K2; PIK3R1; MAP2K1; TCEB1; GAB1; RAP1B; RBX1; PAK3; CDC42
Pancreatic cancer
TGFBR2; BRAF; RALGDS; ARAF; SMAD4; PIK3R5; PLD1; CDC42; TGFB3; ERBB2
Endometrial cancer
TCF7; CTNNA3; APC2; ARAF; PIK3R2; ERBB2; TP53; LEF1; AKT1; CTNNA2
Glioma
HRAS; CAMK2A; AKT2; NRAS; TP53; PLCG2; RAF1; PIK3R3; PRKCB; PIK3CA
Prostate cancer
NKX3; HSP90B1; PDGFC; RELA; CCNE2; LEF1; NKX3-1; HSP90AB1; IGF1; SOS1
Melanoma
PDGFRB; PIK3CG; MET; IGF1R; FGF22; FGF7; FGFR1; FGF14; HRAS; PDGFRA
Chronic myeloid leukemia
KRAS; CBLB; CDK6; PIK3R3; CTBP2; PIK3R1; TGFB2; STAT5B; CTBP1; AKT1
Acute myeloid leukemia
STAT5A; IKBKG; CCNA1; PIK3R5; CEBPA; RUNX1T1; PIK3R1; STAT5B; MAP2K1; PIK3CA
Small cell lung cancer
COL4A1; NFKBIA; AKT1; LAMB4; LAMB1; ITGA2B; CYCS; PTEN; LAMC1; RXRA
Non-small cell lung cancer
RXRB; SOS1; TRP53; ERBB2; PIK3R1; AKT2; RASSF1; RXRG; RAF1; PIK3R5
Central carbon metabolism in cancer
PIK3CB; AKT1; MAP2K2; PFKL; NTRK1; PDHA2; KIT; FGFR2; AKT2; FLT3
Choline metabolism in cancer
TAE1; SLC22A2; KRAS; SLC5A7; TSC1; MAPK1; PLD1; PIK3CG; RAC2; PLA2G4B

Protein Function

PIK3CA has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CA itself. We selected most functions PIK3CA had, and list some proteins which have the same functions with PIK3CA. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CD; ATM; PIK3CB; PIK3CA; PIK3R3; PIK3CG; PIK3C2B; PIK3C2G; PIK3C2A; PIK3C3
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2B; PIK3CB; PIK3C2G; PIK3CG; PIK3CA; PIK3C2A; PIK3CD
Function ATP binding
Related Protein SMARCAD1; TTBK2; PTK2BB; EPB42; ATAD2B; Abcb1b; AKT2L; SMYHC2; ACSL1; TNIKA
Function insulin receptor substrate binding
Related Protein IGF1RA; PRKCZ; INSRR; PIK3CB; IGF1RB; IGF1R; JAK2; INSRA; PIK3CA; PTPN11
Function kinase activity
Related Protein STK25B; NEK4; ADCK3; GRK7B; FGFR1A; HMGXB3; CKBA; PRKACBB; GM7168; PRKCHB
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CB; PIK3C2A; PIK3CD; PIK3CG; PIK3CA
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CD; PIK3CG; PIK3CA; PIK3CB
Function protein binding
Related Protein IL6R; GNA13; GAD1; ALG2; P4HA1; CSDE1; TRIM33; PPIG; WLS; LHFPL5
Function protein kinase activator activity
Related Protein NKX3; DUSP19; PIK3CA; GPRC5B; AGAP2; STK11; FAM58A; MAPK8IP2; STRADA; WNT11
Function protein serine/threonine kinase activity
Related Protein MAPK1; BRAF; MOK; MAP3K4; CAMK1GB; NLK; BMPR1AB; PRKCQ; ERN1; SMG1

Interacting Protein

PIK3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CA.
PIK3R1; IRS1

PIK3CA Related Articles

Ciombor, KK; Wu, C; et al. Recent Therapeutic Advances in the Treatment of Colorectal Cancer. ANNUAL REVIEW OF MEDICINE, VOL 66 66:83-95(2015).
Treilleux, I; Arnedos, M; et al. Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer. ANNALS OF ONCOLOGY 26:120-125(2015).