smad3
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  • Official Full Name
  • SMAD family member 3
  • Background
  • The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
  • Synonyms
  • SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
Cat.#:SMAD3-1918HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD3 Protein, MYC/DDK-tagged
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Cat.#:SMAD3-304HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 Protein, His-tagged
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Cat.#:Smad3-305MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad3 Protein, His-tagged
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Cat.#:SMAD3-295HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, GST-tagged
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Cat.#:SMAD3-31190THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3, His-tagged
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Cat.#:SMAD3-31191THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3
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Cat.#:SMAD3-326HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, His/MBP-tagged
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Cat.#:SMAD3-327HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, His/MBP-tagged
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Cat.#:SMAD3-4599HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant SMAD Family Member 3, His-tagged
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Cat.#:SMAD3-6915HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 3, His-tagged
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Cat.#:SMAD3-532MTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Smad3, His-GST tagged
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Cat.#:SMAD3-5608RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD3 Protein
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Cat.#:SMAD3-4331RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD3 Protein, His-tagged
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Cat.#:SMAD3-6045CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD3
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Cat.#:SMAD3-1094HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 3, GST-tagged
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Cat.#:SMAD3-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD3 cell lysate
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Involved Pathway

SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
MAPK12B; KLF2; ATG12; RBL2; SLC2A4; TGFB1; SKP2; GRB2B; PRKAB1B; MAP2K2A
Cell cycle
ORC1; H3F3B.1; MAPRE1B; CEP290; TMEM188; CCDC99; SMARCA5; MSH4; ORC1L; HTATIP
Endocytosis
USP8; EHD4; VPS29; CHMP2BB; CXCR4A; CYTH4; CAPZA1B; IL2RA; GRK1A; GRK7
Wnt signaling pathway
CACYBP; FOSL1; RAC3A; FBXW2; CAMK2A; PRICKLE2B; PRKCB; RHOA; SFRP2; PRKACAB
TGF-beta signaling pathway
BMP4; PPP2CA; RBL1; LFT2; SMAD3; GDF5; NDR1; ROCK2B; RHOAC; INHBE
Hippo signaling pathway
PRKCI; FZD5; CCND1; AJUBA; YWHAE; YAP1; ID1; WNT10B; ID2; WNT1
Adherens junction
CSNK2A2; ACTN3; CDC42L; PTPRFB; RHOA; INSR; ERBB2; FYNB; NLK; CSNK2A2A
Signaling pathways regulating pluripotency of stem cells
MAPK13; STAT3; PIK3R3; FGFR2; ACVR1; WNT16; FZD9; AXIN2; LEFTY2; ESX1
Chagas disease (American trypanosomiasis)
C1QC; MAPK3; PLCB4; PPP2CB; PIK3CG; GNAQ; NFKB1; GNAS; IFNGR1; CD3E
Hepatitis B
PTEN; TGFBR1; TGFB1; PIK3CD; IFNA14; FAS; EGR2; OSTN; MAP2K2; ELK1
HTLV-I infection
DLG1; PTTG1; TBP; TGFB2; MAP3K1; HLA-DOB; MYB; NRP1; PRKACA; HLA-F
Pathways in cancer
ETS1; LAMA5; PIK3CD; CBLB; NRAS; FZD3; FGFR1; WNT3; CDH1; RXRA
Colorectal cancer
TGFB3; RHOA; TRP53; PIK3R3; DCC; BIRC5; TCF7; BAX; CASP9; TGFBR1
Pancreatic cancer
AKT1; BCL2L1; STAT1; PIK3CA; BAD; AKT2; PIK3R1; RALGDS; PIK3R5; ERBB2
Chronic myeloid leukemia
PIK3R1; MECOM; CRKL; RELA; CBLC; TGFBR1; PIK3CD; CDK6; HDAC1; SMAD3
Inflammatory bowel disease (IBD)
HLA-DPB1; STAT6; IL1A; IL12RB2; RORA; TGFB2; HLA-DRB4; H2-AA; IL2RG; TLR2

Protein Function

SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.
Function
Related Protein
Function R-SMAD binding
Related Protein JUN; PAX6; AXIN1; FOS; CTNNB1; RANBP3; PMEPA1; FOXH1; SMAD3; C18orf1
Function RNA polymerase II activating transcription factor binding
Related Protein EP300; TBX3; POU1F1; CREBBP; NEUROD1; ISL1; ATF2; DUSP26; TBX20; NHLH2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOSL1A; NFE2L3; NKX6-2; POU1F1; ZNF331; ZNF680; NR3C1; NR2C1; KCNIP3; TCF3A
Function bHLH transcription factor binding
Related Protein LMO2; TCF21; MAP3K10; TWIST1; USF2; TCF12; ISL1; TCF3A; IKZF4; USF1
Function beta-catenin binding
Related Protein PSEN1; C; CTNNA3; LZTS2A; SLC9A3R2; FAM123B; CDH1; APC; TCF7L2; CXADR
Function chromatin DNA binding
Related Protein HIST1H1A; AASS; XBP1; HIST1H1D; H2AFY2; THRA; NKAP; SMAD3; MED1; SLAMF7
Function co-SMAD binding
Related Protein CITED1; GATA4; SMAD3; TRIM33; USP9X; FOXH1; TGIF1; SMAD6; SMAD2; SMAD1
Function collagen binding
Related Protein ADAM9; SMAD7; CHADL; LRRC15; SMAD4; COMP; MMP13; DCN; PODN; ANTXR1
Function core promoter proximal region sequence-specific DNA binding
Related Protein CXXC1; UHRF1; SP3A; DMRTC1C2; DMRT2; DMRT2B; KLF1; SMAD3; SP3; DMRTC2
Function enhancer binding
Related Protein LEF1; TCF12; SMAD3; RAI1; TCF3; SMAD2; ELL3; AHR; SP1; ARNT
Function identical protein binding
Related Protein TRAF2; GOT2B; KIRRELA; CEACAM5; CBLL1; CAV1; HSP90AA1; RILPL2; CASP6; SSNA1
Function phosphatase binding
Related Protein SMAD2; ELL; PPP1R37; SH3RF2; ELFN2; MAST2; KLRAQ1; SMAD3; CTSC; PPP1R35
Function protein binding
Related Protein PACSIN3; GAB1; KLF2; GSG1; PLXNB2; FLT3; TGM2; BEND5; TBRG1; NEDD8
Function protein heterodimerization activity
Related Protein H2AFJ; RARA; BIRC5; HIST2H2L; CXorf15; RALGAPA2; NEUROD2; ATF1; APITD1; HIST1H4E
Function protein homodimerization activity
Related Protein BOKB; OSTA; MAP3K13; CREB3L3; APOA1BP; CADM1B; RAB11FIP4A; NR0B2; PRPS1L1; TPR
Function protein kinase binding
Related Protein TMEM173; CALM2; FAM83B; MAP3K5; HDAC4; CDKN2D; VDAC1; STXBP1; CACNB4; CAV2
Function sequence-specific DNA binding
Related Protein SOX13; ZSCAN23; CAMTA2; HOXB6; NR2F1A; ELF2B; CREBZF; HOXA4A; HOXA7; DBX2
Function transcription factor activity, RNA polymerase II core promoter sequence-specific
Related Protein SMAD3; MEF2C; MAX; HEYL; TFAP2B; HEY2; PAX7; HEY1; NKX3
Function contributes_to transcription factor activity, protein binding
Related Protein SMAD3; SMAD4
Function transcription factor activity, sequence-specific DNA binding
Related Protein TRERF1; TADA2A; ZFP354C; SOX5; DMRT2A; BUD31; FOXD4; ZNF134; IRF4A; HOXD10
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein VDR; GATA4; TAF6; HNRNPAB; TAF12; SOX1B; NKX2; TAF10; SOX19A; VDRB
Function transcription factor binding
Related Protein EP300; NCOA2; MYBBP1A; PDX1; NAB1; HAND1; BPTF; PARD6A; TBP; ATOH8
Function transcription regulatory region DNA binding
Related Protein ARRB1; WNT11; FOXC2; GRHL1; HNRNPL; RELA; MLL1; PPARG; JUN; SALL1A
Function transforming growth factor beta receptor binding
Related Protein INHBA; GDF6; MSTNB; TGFB1A; TGFBR3; NDR1; BMP4; GDF10; TGFB2; INHBB
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD3; SMAD2; SMAD9; SMAD1
Function ubiquitin binding
Related Protein C6orf106; UBXN2A; CXCR4; SHRPRBCK1R; FAF2; UBXN2B; VPS36; PARK2; USP5; BCL10
Function ubiquitin protein ligase binding
Related Protein GABARAP; SUMO1; NLK; ARRB1; NPLOC4; CUL1B; OTUB1; CUL4B; UBE2J1; UCHL1
Function zinc ion binding
Related Protein MT1G; FNTB; ADAM33; ANPEP; MORC3B; RABGEF1; TRIM48; L3MBTL2; ZFP622; DPEP1

Interacting Protein

SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.
SMAD4; SKI

SMAD3 Related Articles

Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).

SMAD3 Related Gene Family

TGF