smad3
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  • Official Full Name
  • SMAD family member 3
  • Background
  • The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
  • Synonyms
  • SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
Cat.#:SMAD3-1918HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD3 Protein, MYC/DDK-tagged
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Cat.#:SMAD3-304HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 Protein, His-tagged
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Cat.#:Smad3-305MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad3 Protein, His-tagged
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Cat.#:SMAD3-295HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, GST-tagged
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Cat.#:SMAD3-31190THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3, His-tagged
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Cat.#:SMAD3-31191THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3
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Cat.#:SMAD3-326HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, His/MBP-tagged
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Cat.#:SMAD3-327HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD3 protein, His/MBP-tagged
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Cat.#:SMAD3-4599HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant SMAD Family Member 3, His-tagged
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Cat.#:SMAD3-6915HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 3, His-tagged
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Cat.#:SMAD3-532MTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Smad3, His-GST tagged
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Cat.#:SMAD3-5608RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD3 Protein
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Cat.#:SMAD3-4331RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD3 Protein, His-tagged
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Cat.#:SMAD3-6045CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD3
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Cat.#:SMAD3-1094HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 3, GST-tagged
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Cat.#:SMAD3-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD3 cell lysate
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Involved Pathway

SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PRKAA1; ARAF; FOXO3; HRAS; PIK3R1; AKT2; MAPK1; IRS2; Fasl; KRAS
Cell cycle
NEK6; PDS5B; CDK5RAP2; CSNK2A1; HTATIP; CENPJ; E2F3; GINS1; CDC14AB; MIS12
Endocytosis
ASAP2A; EHD1B; ERBB3A; BC2; WASLB; FOLR3; GIT1; ASAP1; FOLR1; HSPA1A
Wnt signaling pathway
DKK1B; MAPK8; TBL1X; PRKCBB; PPP3R1; CAMK2B; AXIN1; WNT8A; LRP6; FBXW11
TGF-beta signaling pathway
ID1; RHOA; BMP2; BMP2B; ACVR1B; MAPK3; TGFBR1; CHRD; GDF7; INHBB
Hippo signaling pathway
FZD3; APC2; BIRC5; LATS1; YAP1; TGFBR2; WNT8B; DLG3; WNT9B; WWTR1
Adherens junction
TJP1; RHOAB; WASLA; RHOA; MAP3K7; RHOAC; INSRA; SNAI2; ACTB2; ACP1
Signaling pathways regulating pluripotency of stem cells
ID1; SMAD9; HESX1; PIK3R1; SMAD2; WNT5A; APC; KLF4; KRAS; SMAD5
Chagas disease (American trypanosomiasis)
IL10; TLR6; CD3D; CCL3L1; PPP2R1A; PIK3CG; TNFRSF1A; TLR9; PIK3R2; IL-8
Hepatitis B
IFNA4; Fasl; NFKBIA; IFNA12; MAPK3; CREB3L2; MAP3K1; IKBKG; IFN-a; PIK3CG
HTLV-I infection
POLE3; TGFBR1; TRP53INP1; HLA-DMB; HLA-B; CDC27; SLC25A4; TGFB3; VDAC1; BAX
Pathways in cancer
BIRC2; HHIP; RALBP1; RB1; MAPK9; PML; Adcy4; Ar; FGF22; TCEB1
Colorectal cancer
CCND1; TGFB3; GSK3B; KRAS; FOS; RHOA; TGFBR1; BAD; AXIN1; AKT1
Pancreatic cancer
RAD51; CASP9; PIK3CG; MAPK1; MAP2K1; BRAF; NFKB1; TRP53; PIK3CA; RALB
Chronic myeloid leukemia
IKBKG; SMAD4; RELA; KRAS; ABL1; TP53; PIK3R1; CBL; BRAF; NFKBIA
Inflammatory bowel disease (IBD)
IL18RAP; Il2; TNF; IL12B; HLA-DOB; FOXP3; TLR2; TGFB1; IFNG; TGFB2

Protein Function

SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.
Function
Related Protein
Function R-SMAD binding
Related Protein ZEB2; AXIN1; SMAD4; SMAD3; SMURF1; TRIM33; ANKRD1; FOXH1; ZC3H3; SMAD6
Function RNA polymerase II activating transcription factor binding
Related Protein SETD3; EP300; LMO2; ATF2; EGR2; NEUROD1; NFE2L2; TBX3; LDB1; CTNNB1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZFP746; CEBPE; SRF; ATOH1; KLF17; GLI2; ESRRA; BATF3; HNRNPC; PDX1
Function bHLH transcription factor binding
Related Protein TCF3A; ISL1; SP1; HAND1; TCF4; RUNX2; SMAD3; BHLHE40; TWIST1; TCF12
Function beta-catenin binding
Related Protein SLC9A3R2; PTBP3; CD2AP; PTPRK; MED12L; CTNNA1; AXIN2; KLF4; PTPRU; CDH24
Function chromatin DNA binding
Related Protein PRDM14; NKAP; SMAD3; SRF; XBP1; INSM1B; AASS; NEUROG3; HIST1H1E; RUVBL2
Function co-SMAD binding
Related Protein USP9X; SMAD3; TGIF1; SMAD2; TRIM33; SMAD6; GATA4; CITED1; FOXH1; SMAD1
Function collagen binding
Related Protein TLL1; PDGFA; SMAD4; HSD17B12; ITGA1; SERPINH1; ABI3BP; SERPINH1B; ADAM9; ASPN
Function core promoter proximal region sequence-specific DNA binding
Related Protein DMRT1; MEF2C; SP3A; DMRT3; PAX2; GATA3; KLF4; CXXC1; DMRTC1B; CREBBP
Function enhancer binding
Related Protein SP1; LEF1; AHR; SMAD2; TCF12; ARNT; SMAD3; TCF3; SOX9; RAI1
Function identical protein binding
Related Protein ZBTB16; RASSF1; CSNK2B; PRKAB2; CLDN7; ADIPOQ; COL1A1; CUBN; LYZ2; CALHM1
Function phosphatase binding
Related Protein SMAD3; CTSC; SYTL2; ELL; PPP1R27; MAPK3; CNST; SLC9A3R2; TSC2; KLRAQ1
Function protein binding
Related Protein RGL2; EPAS1; STRA13; 2610109H07Rik; NAA35; CYFIP1; CCDC141; ATG4A; GATSL3; PPP1R3C
Function protein heterodimerization activity
Related Protein KCNK9; GCLM; H2AFY; RAB3GAP2; SMC1A; HIST1H2BF; ANO9A; HIST4H4; SDCBP; GAD2
Function protein homodimerization activity
Related Protein CISD2; DPP4; HPRT1; MECOM; TPD52L1; DMRTB1; AMBP; SHMT1; ADRA2A; NADKD1
Function protein kinase binding
Related Protein GYS1; RACGAP1; RAB8A; SKI; FGR; CDKN2A; MSN; IBTK; AGAP2; DPYSL2
Function sequence-specific DNA binding
Related Protein ZBTB4; DHARMA; BATF; RXRAB; AHR2; KLF5; E2F1; IRX1B; ZFP191; HOXD1
Function transcription factor activity, RNA polymerase II core promoter sequence-specific
Related Protein TFAP2B; PAX7; MAX; NKX3; MEF2C; SMAD3; HEYL; HEY1; HEY2
Function contributes_to transcription factor activity, protein binding
Related Protein SMAD3; SMAD4
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZBTB11; SOX5; HOXB6B; GLI4; ZFP821; ETV1; IRF3; NFATC1; ZNF500; HLF
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein RXRA; TAF6; NFE2L2A; SOX19A; MAFGB; SOX1B; NKX2; TAF7; TAF12; GATA4
Function transcription factor binding
Related Protein EP300; EPN1; GTF2F1; PIAS2; HES3; STK4; RPS3; POU5F1; BPTF; APBB3
Function transcription regulatory region DNA binding
Related Protein KLF1; NFE2L2; HNF1A; YY1; SREBF1; FOXA3; RCOR1; BRCA1; MTERFD1; CTNNB1
Function transforming growth factor beta receptor binding
Related Protein BMP7A; INHBE; LEFTY2; GDF1; INHBA; TGFBRAP1; BMP7; INHA; SMAD2; BMP5
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD2; SMAD9; SMAD1; SMAD3
Function ubiquitin binding
Related Protein SQSTM1; OTUB1; NBR1; FAF2; SPRTN; KCNS1; UBXN1; UBAP1; UBR5; D17WSU92E
Function ubiquitin protein ligase binding
Related Protein WFS1; OTUB1; TRIOBP; CUL2; UBE2NB; NLK; CDC34; MC4R; UBE2G1B; UBE2B
Function zinc ion binding
Related Protein AICDA; DMD; KDM2A; S100A6; FANCL; SETDB1A; PXNA; FHL2A; RNF112; RBM20

Interacting Protein

SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.
SMAD4; SKI

SMAD3 Related Articles

Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).

SMAD3 Related Gene Family

TGF