tgfb2
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  • Official Full Name
  • transforming growth factor, beta 2
  • Background
  • Transforming growth factor betas (TGF betas) mediate many cell-cell interactions that occur during embryonic development. Three TGFbs have been identified in mammals. TGF beta1, TGF beta2 and TGF beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. This antibody reacts with the precursor and mature form of TGF beta2 and to a lesser extent TGF beta3, but does not cross react with TGF beta1.
  • Synonyms
  • TGFB2; transforming growth factor, beta 2; transforming growth factor beta-2; G-TSF; cetermin; polyergin; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor; TGF-beta2; MGC116892; LDS4
Cat.#:TGFB2-1119RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus TGFB2 Protein, His-tagged
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Cat.#:TGFB2-577HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2
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Cat.#:TGFB2-015HTag:
Source (Host):CHO cellSpecies:Human
Product nameRecombinant Human TGFB2 Protein
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Cat.#:TGFB2-016HTag:
Source (Host):HEK293 cellSpecies:Human
Product nameRecombinant Human TGFB2 Protein
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Cat.#:TGFB2-127HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TGFB2 Active
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Cat.#:TGFB2-1566HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human TGFB2, Active
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Cat.#:TGFB2-228HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB2 Protein, His-tagged
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Cat.#:TGFB2-22HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TGFB2, His-tagged
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Cat.#:TGFB2-31244THTag:
Source (Host):Species:Human
Product nameRecombinant Human TGFB2
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Cat.#:TGFB2-348HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2
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Cat.#:TGFB2-377HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2
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Cat.#:TGFB2-438HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Transforming Growth Factor Beta 2
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Cat.#:TGFB2-467HTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2, Monomeric Form
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Cat.#:TGFB2-519HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant human TGFB2
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Cat.#:TGFB2-556HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB2, His tagged
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Cat.#:TGFB2-8328HTag:
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human TGFB2
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Cat.#:TGFB2-16704MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TGFB2 Protein
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Cat.#:Tgfb2-620MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Tgfb2
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Cat.#:Tgfb2-849MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfb2 Protein, His-tagged
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Cat.#:Tgfb2-229RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb2 Protein, His-tagged
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Cat.#:TGFB2-6037RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFB2 Protein
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Cat.#:TGFB2-4687RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFB2 Protein, His-tagged
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Cat.#:TGFB2-1053CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine TGFB2 Protein, His-tagged
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Cat.#:TGFB2-2725CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFB2
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Cat.#:TGFB2-9735ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFB2
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Cat.#:TGFB2-227CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TRIM21 Protein, His-tagged
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Cat.#:TGFB2-540HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human TGFB2
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Cat.#:TGFB2-632HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2
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Cat.#:TGFB2-633HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2, His-tagged
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Cat.#:TGFB2-004NTag:N/A
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 2, Dimeric Form
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Cat.#:TGFB2-1119HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TGFB2 293 Cell Lysate
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Cat.#:TGFB2-104HTag:
Source (Host):Species:Human
Product nameHuman Transforming Growth Factor beta-2( rec DNA )Reference standard
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Cat.#:TGFB2-97BTag:
Source (Host):Species:Bovine
Product nameBovine Transforming Growth Factor beta-2 Reference standard
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Involved Pathway

TGFB2 involved in several pathways and played different roles in them. We selected most pathways TGFB2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MEF2CB; MAP2K3; Fgf15; HRASA; MAPK12B; MAP3K5; FGF6; FGF20B; PPP3R2; TNF
Cytokine-cytokine receptor interaction
IL-8; RELT; IFNAR1; OSMR; CCL20A.3; GM2506; IFNB; IL12RB2; Pdgfa&Pdgfb; IFNA1
FoxO signaling pathway
G6PCA.1; EP300; SGK2B; HRASA; MAPK12B; MAPK11; IGF1RB; RAF1A; TGFB2; G6PC
Cell cycle
ORC2; LEMD3; GINS4; SMC1B; ACD; CENPN; DCTN3; SKP1; ORC3L; FOXM1
Endocytosis
SNX32; IQSEC1; ARPC1A; SH3GL2; SNX1A; STAM; EPN1; SH3GL3A; MVB12BB; GRK7
TGF-beta signaling pathway
PPP2R1A; INHBAB; TGFBR2; ACVR1B; LFT2; CUL1B; SMAD3A; CUL1A; ROCK2B; LEFTY1
Osteoclast differentiation
PPP3R1; PIK3CD; CSF1R; MAP3K14; IKBKG; NFKBIA; MAPK3; NFKB2; PIK3R3; AKT2
Hippo signaling pathway
WNT10B; LLGL1; AXIN2; PRKCZ; CTGF; PPP1CC; LIMD1; LLGL2; WNT8B; BBC3
Leishmaniasis
C3; MYD88; IFNGR2; NOS2; MAPK12; CYBA; MAPK1; FOS; PTGS2; H2-AA
Chagas disease (American trypanosomiasis)
CD3E; CD3D; CXCL8; PIK3R1; TGFBR2; GNAI3; PIK3R2; TNF; MAPK10; NFKBIA; IRAK4
Malaria
TLR4; IL6; ICAM1; DARC; CD81; KLRC4-KLRK1; SELP; CCL2; KLRB1; HBB-B2
Toxoplasmosis
HLA-DMA; HLA-DRA; MAPK8; MAPK12; LAMC2; ALOX5; AKT1; IFNGR2; HLA-DOA; TLR4
Amoebiasis
COL4A4; C9; IL12A; TGFB1; LAMC1; IL12B; PRKCB; RAB5B; COL3A1; ACTN1
Tuberculosis
CASP9; HLA-DMA; Pla2r1; TRADD; PIK3C3; CD209C; Il23a; ATP6V0D2; CD14; CLEC7A
Hepatitis B
HRAS; NFKB1; OSTN; KRAS; CREB3L1; PIK3CG; RB1; FOS; DDX3X; STAT5B
HTLV-I infection
TNFRSF13C; SMAD4; VAC14; CRTC1; IL2RA; ZFP36; ANAPC1; SFPI1; POLD4; PDGFA
Pathways in cancer
CKS2; MMP1A; BRAF; PRKACA; KITLG; LAMA2; TFG; SMAD3; IL6; FADD
Proteoglycans in cancer
SMO; PPP1CA; TRP53; DDX5; RRAS2; CAV2; ACTG1; HPSE2; PTK2; FZD7
MicroRNAs in cancer
CDC25A; PIM1; HDAC4; ABCC1; BCL2; MET; HMOX1; ABCB1A; PDGFA; RPTOR
Colorectal cancer
AKT1; ARAF; RALGDS; MAPK9; MAP2K1; SMAD3; RAC2; LEF1; BIRC5; MSH2
Renal cell carcinoma
RAPGEF1; PAK2; FLCN; CDC42; MAPK1; PIK3CG; RAC1; ARNT2; ARNT; PIK3R1
Pancreatic cancer
PIK3R1; TRP53; ARAF; MAPK9; BAD; BCL2L1; TGFB3; VEGFA; IKBKB; CCND1
Chronic myeloid leukemia
CCND1; PIK3R2; PIK3R5; TGFBR2; MAP2K1; BCL2L1; BCR; GAB2; NFKB1; HDAC1
Inflammatory bowel disease (IBD)
Il23a; Il12b; IL1B; FOXP3; Il4ra; TBX21; RORC; H2-AA; STAT3; IL17F; RORA
Rheumatoid arthritis
GM-CSF; CCL20; IL1B; ATP6V1C1; CTLA4; IL6; MMP1; TGFB2; TNF; CCL3L3
Hypertrophic cardiomyopathy (HCM)
TPM2; CACNB1; CACNA2D3; TTN; ATP2A2; TPM1; ITGA10; MYBPC3; SGCA; ITGA8
Dilated cardiomyopathy
TNF; LMNA; LAMA2; ATP2A2; CACNB4; CACNB2; CACNA2D1; MYL2; ITGA3; CACNA2D2

Protein Function

TGFB2 has several biochemical functions, for example, beta-amyloid binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB2 itself. We selected most functions TGFB2 had, and list some proteins which have the same functions with TGFB2. You can find most of the proteins on our site.
Function
Related Protein
Function beta-amyloid binding
Related Protein FBXO2; MAPK8IP2; APBA3; COL25A1; LDLRAD3; APBB1; OLFM1; APOA1; CD74; APOEB
Function cytokine activity
Related Protein Ccl12; SPP1; VEGFA; IL32; IL11; CSF1B; TNFSF8; RNF207B; LTA; BMP2B
Function growth factor activity
Related Protein BMP7A; LIF; THPO; OSM; GRN; IGF2B; NDR2; CECR1; NTF4; ANGPTL3
Function protein binding
Related Protein CX3CR1; ZNF559-ZNF177; SMNDC1; CCDC141; ARHGAP44; CAPN1; HNRNPF; CENPW; NKD1; CCDC153
Function protein heterodimerization activity
Related Protein NAE1; HIST1H2BM; TAF11; KCNH5; H2-Q10; MCL1A; HEYL; RRAGC; ROPN1B; FZD1
Function protein homodimerization activity
Related Protein NFS1; RAB11FIP2; IRAK1; SRR; TGFB2; HSPB6; NR4A2; CDH13; ASMT; TFAP2B
Function receptor binding
Related Protein ASIP; PRDX5; SSFA2; CADM1; STRAP; Itga10&Itgb1; ANG; SLC27A2; GFRA3; LTA
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR1AB; BMPR1BB; ACVR1L; ACVR2B; SLKA; BMPR2; OXSR1B; ACVR2A; ACVR1BA; PAK2B
Function transforming growth factor beta receptor binding
Related Protein GDF6; INHBC; BMP2B; BMP8A; INHBB; BMP2; SMAD3; GDF6B; GDF1; SMAD2
Function type II transforming growth factor beta receptor binding
Related Protein BAMBI; ENG; TGFB1; TGFB3; TGFB2; TGFBR3; TGFBR1; TGFB1A
Function type III transforming growth factor beta receptor binding
Related Protein TGFB2; TGFBR2; TGFB1; TGFB3

Interacting Protein

TGFB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB2.
APP; BMP2

TGFB2 Related Articles

Niarami, MD; Masoudi, AA; et al. ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF GHSR AND TGFB2 GENES WITH GROWTH AND BODY COMPOSITION TRAITS IN SIRE AND DAM LINES OF A BROILER CHICKEN. ANIMAL BIOTECHNOLOGY 25:13-22(2014).
Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).

TGFB2 Related Gene Family

TGF