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Recombinant Human TGFB2 Protein, His-tagged

Cat.No. : TGFB2-228H
Product Overview : Recombinant Human TGFB2(Ser303~Glu414) fused with His tag at N-terminal was expressed in E. coli.
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 16.7kDa
Identity : Reconstitute in PBS or others
Protein length : Ser303~Glu414
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : TGFB2 transforming growth factor, beta 2 [ Homo sapiens ]
Official Symbol : TGFB2
Synonyms : TGFB2; transforming growth factor, beta 2; transforming growth factor beta-2; G-TSF; cetermin; polyergin; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor; TGF-beta2; MGC116892;
Gene ID : 7042
mRNA Refseq : NM_001135599
Protein Refseq : NP_001129071
MIM : 190220
UniProt ID : P61812

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of TGFB2 in wound healing and tissue repair? 05/16/2022

It can promote wound healing and tissue repair by stimulating the proliferation and migration of fibroblasts and epithelial cells, as well as promoting collagen synthesis.

Are there potential applications for TGFB2 inhibitors or activators? 02/12/2022

Inhibitors or activators targeting TGFB2 may have potential applications for the treatment of a variety of diseases, including cancer, inflammatory diseases, autoimmune diseases, etc.

How does TGFB2 regulate cell proliferation and differentiation? 10/15/2021

TGFB2 can regulate cell proliferation and differentiation by binding to its receptor and activating downstream signal transduction pathways.

What is the relationship between TGFB2 and immune regulation? 03/28/2021

This protein can be used as an immunomodulator to participate in the differentiation and function of immune cells, as well as the regulation of inflammatory responses.

How is the expression level of TGFB2 regulated? 11/03/2020

The expression level of TGFB2 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.

What is the association of TGFB2 with other proteins or cytokines? 09/17/2020

TGFB2 has a variety of associations with other proteins and cytokines. For example, it may interact with vascular endothelial growth factor (VEGF) and be involved in angiogenesis, and may also interact with apoptosis-related proteins to regulate the apoptotic process.

Customer Reviews (3)

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Reviews
11/19/2022

    No complicated experimental steps, suitable for beginners.

    06/28/2022

      Excellent performance in Western blot, even if stored for a long time will not affect its performance.

      07/18/2021

        The endotoxin levels were low enough not to interfere with the results.

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