Recombinant Human Transforming Growth Factor Beta 2

• Cat.No.: TGFB2-438H
• Product Overview: Recombinant Human Transforming Growth Factor Beta 2 is expressed inE. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development. This cytokine is produced in a human cell expression system with serum-free, chemically defined media.
• Purity: >98% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
• Molecular Weight: 35.8 kDa.
• Presentation: Solution containing 50 mM TRIS, 100 mM NaCl, 1% BSA, 0.02% Sodium Azide, pH 7.4.
• Biological Activity: Annexin V exhibits anti-phospholipase activity and binds to phosphatidylserine (PS).
• Application: FITC labelling allows simple direct detection of PS by FACS analysis. Counterstaining by propidium iodide allows the discrimination of apoptotic cells.
• Storage: Stable at 2°-8°C as indicated on the label. Do not freeze!

Gene Information

• Gene Name: TGFB2 transforming growth factor, beta 2 [ Homo sapiens ]
• Synonyms:
  TGFB2; Transforming growth factor beta 2; MGC116892; TGF-beta2; Transforming growth factor beta-2; TGF-beta-2; Glioblastoma-derived T-cell suppressor factor; G-TSF; BSC-1 cell growth inhibitor; Polyergin; Cetermin
• Gene ID: 7042
• mRNA Refseq: NM_001135599
• Protein Refseq: NP_001129071
• MIM: 190220
• UniProt ID: P61812
• Chromosome Location: 1q41
• Pathway: Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Renal cell carcinoma; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway
• Function: beta-amyloid binding; cytokine activity; growth factor activity; protein heterodimerization activity; protein homodimerization activity; receptor signaling protein serine/threonine kinase activity; type II transforming growth factor beta receptor binding

Citation

Wnt-Induced Stabilization of KDM4C Is Required for Wnt/β-Catenin Target Gene Expression and Glioblastoma Tumorigenesis

Journal: Cancer Research    Data: 2019/12/30

Authors: Yaohui Chen, Runping Fang, Suyun Huang

Article Snippet:Empty anti-Flag agarose beads were used as a control.Empty anti-Flag agarose beads were used as a control.. The in vitro ubiquitination assay was performed by incubating KDM4C or control agarose beads at 37°C for 1 hour with E1 ubiquitinactivating enzyme UBE1, E2-conjugating enzyme UbcH5c, HA-ubiquitin, and adenosine triphosphate (all from Boston Biochem) in the presence or absence of recombinant β-TrCP protein (Creative BioMart, Research. on January 1, 2020.. ? 2019 American Association for Cancercancerres.aacrjournals.org Downloaded from 7 BTRC-2545M).? 2019 American Association for Cancercancerres.aacrjournals.org Downloaded from 7 BTRC-2545M).