| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
47.6 kDa |
| AA Sequence : |
MHYCVLSAFLILHLVTVALSLSTCS TLDMDQFMRKRIEAIRGQILSKLKL TSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSD EEYYAKEVYKIDMPPFFPSENAIPP TFYRPYFRIVRFDVSAMEKN ASNLVKAEFRVFRLQNPKARVPEQR IELYQILKSKDLTSPTQRYIDSKVV KTRAEGEWLSFDVTDAVHEW LHHKDRNLGFKISLHCPCCTFVPSN NYIIPNKSEELEARFAGIDGTSTYT SGDQKTIKSTRKKNSGKTPH LLLMLLPSYRLESQQTNRRKKRALD AAYCFRNVQDNCCLRPLYIDFKRDL GWKWIHEPKGYNANFCAGAC
PYLWSSDTQHSRVLSLYNTINPEAS ASPCCVSQDLEPLTILYYIGKTPKI EQLSNMIVKSCKCSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways : |
Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway |
