TNFSF10
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 10
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Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Rat
- Rhesus
- Rhesus Macaque
- Rhesus monkey
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- Human cells
- Mammalian Cell
- NS0
- C
- His
- DYKDDDDK
- Fc
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- initial Met
- mFc
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- TNFSF10 Related Articles
- TNFSF10 Related Gene Family
- TNFSF10 Related Research Area
- TNFSF10 Related Signal Pathway
TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | Il23a; Il12b;CCL22;CCL21;IFNA12;CCR6A;IL5;VEGFC;TGFBR1B;TSLP |
FoxO signaling pathway | FOXO1A;INSB;CCND2A;GADD45G;PRKAA2;FOXO3A;PIK3R5;PDPK1;PTEN |
Apoptosis | NFKBIAB;STK24B;PRKAR1A;RELA;PLEC;E2F1;AKT1;SATB1;GZME |
Natural killer cell mediated cytotoxicity | PIK3CG;CD48;KLRK1;GZMB;IFNAR2;HLA-C;TNFRSF10D;MAPK1;IFNA7 |
Measles | HSPA8;SH2D1A;FAS;PIK3CA;CD28;cgr2b;IL2RA;PIK3CB;MYD88 |
Influenza A | IL18;IFIH1;CASP1;IFNA4;HLA-DOB;PRSS2;IFNAR2;VDAC1;ACTG1 |
TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | IL36B;GM13278;Cxcl15;IL22;TNFSF12;CMTM8;IFNE;NODAL;LFT2 |
metal ion binding | ZFAND5B;MMP23BB;ERCC2;TH2;ATF7B;CYB5D1;ZFP184;TRAF4A;ZDHHC18 |
protein binding | MUTYH;SF3B4;CPSF6;GPKOW;SDCBP2;GAB3;GATA1A;IRAK1BP1;SLC14A2 |
receptor binding | CCL17;ANGPTL2;FGF24;LAMA3;CXCL1;HSPA1A;MAP7;PTK6;EPB49 |
tumor necrosis factor receptor binding | TRAF3;TNFSF11;TNFSF12;TRAF6;TRAF4;TNF;TNFSF15;TNFSF4;TRIM37 |
TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.
TNFRSF10B
- Q&As
- Reviews
Q&As (7)
Ask a questionTNFSF10 protein holds great therapeutic potential as a target for various diseases. Studies have shown that utilizing its apoptosis-inducing ability, novel treatment strategies can be developed for cancer. Furthermore, TNFSF10 protein can be utilized in the design of immunotherapies to enhance immune responses. However, further research is needed to optimize TNFSF10 therapeutic strategies and gain a deeper understanding of its specific mechanisms in disease development.
The cellular source of TNFSF10 protein is diverse, including tumor cells, lymphocytes, monocytes, and dendritic cells. Additionally, some epithelial cells and endothelial cells also express TNFSF10 protein.
TNFSF10 protein has diverse physiological functions in tissue remodeling. It promotes inflammation, angiogenesis, and fibrosis processes. Moreover, TNFSF10 protein is involved in immune regulation and tissue repair, playing a crucial role in maintaining normal tissue functionality and structure.
TNFSF10 modulates multiple cellular processes beyond apoptosis induction. It can activate various signaling pathways, including the NF-κB pathway, which plays a key role in immune and inflammatory responses. TNFSF10 also regulates cell migration and invasion properties, affecting metastasis in some cancer types. Furthermore, TNFSF10 can promote immune cell activation and cytokine production, contributing to the regulation of the immune system.
TNFSF10 protein plays a significant role in cancer progression and metastasis. It induces apoptosis in tumor cells, inhibits tumor growth and metastasis, and regulates immune responses. Moreover, TNFSF10 protein interacts with other signaling pathways, participating in the modulation of the tumor microenvironment.
The transcriptional regulation of TNFSF10 gene involves various factors. Known regulators include transcription factors NF-κB, STAT3, and DNA methylation status. These factors modulate the expression levels of TNFSF10 gene, thereby influencing the production of TNFSF10 protein.
TNFSF10 protein interacts with its receptor, death receptor 5 (DR5), and triggers apoptosis pathway to induce cell death. Additionally, TNFSF10 protein also interacts with other ligands and receptors, such as TRAIL-R1 and TRAIL-R2, thereby regulating cell survival and death signaling transduction.
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