tnfsf10
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 10
  • Background
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Synonyms
  • TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;
Cat.#:TNFSF10-302HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10 Protein, His-tagged
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Cat.#:TNFSF10-31604THTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10, FLAG-tagged
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Cat.#:TNFSF10-4752HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10
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Cat.#:TNFSF10-556HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10 protein, His-tagged
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Cat.#:TNFSF10-557HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10, Fc tagged
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Cat.#:TNFSF10-635HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TNFSF10 Protein
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Cat.#:TNFSF10-636HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10, None tagged
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Cat.#:Tnfsf10-1509MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Tnfsf10
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Cat.#:TNFSF10-17171MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNFSF10 Protein
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Cat.#:Tnfsf10-504MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf10, His-tagged
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Cat.#:TNFSF10-851MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TNFSF10 Protein, His-tagged
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Cat.#:Tnfsf10-579RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfsf10 protein, His & GST-tagged
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Cat.#:TNFSF10-1191RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus TNFSF10 Protein
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Cat.#:TNFSF10-1634RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFSF10 Protein
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Cat.#:TNFSF10-4871RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TNFSF10 Protein, His-tagged
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Cat.#:TNFSF10-577DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TNFSF10 protein, His & T7-tagged
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Cat.#:TNFSF10-5949CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFSF10
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Cat.#:TNFSF10-710ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TNFSF10
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Cat.#:TNFSF10-2154HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF10, His-tagged
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Cat.#:TNFSF10-892HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNFSF10 293 Cell Lysate
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Cat.#:TNFSF10-18HTag:
Source (Host):Species:Human
Product nameHuman TNF-related Apoptosis-Inducing Ligand (trail) Reference standard
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Cat.#:CSC-P0164Tag:
Source (Host):Species:
Product nameAnti-Human TRAIL MAb Stable Cell Line-CHO
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Involved Pathway

TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
BMP7B; CCR6A; PF4; ACVR1BA; Il4ra; IFNGR2; TNFRSF11B; FIGF; PDGFB; TNFSF13
FoxO signaling pathway
SGK2B; TGFBR1A; STK11; PLK1; MAPK12; GABARAPL1; MAP2K2; RAG2; HOMER2; MAP2K1
Apoptosis
PPP3CCB; DSG3; TNFRSFA; PPP3R1B; CASP3A; STK24A; MYD88; CAPN2L; PRKACBB; CASP8
Natural killer cell mediated cytotoxicity
SHC4; IFNA2; IFNA4; TNFRSF10D; RAF1; LCP2; BID; HLA-B; MAPK1; GM-CSF
Measles
RELA; CD209; TAB2; CD3E; CD3D; IRAK4; HSPA2; CLEC4M; IFNA4; STAT3; Il2
Influenza A
BMA2; Ifna11; MAP2K4; EP300; IFNA21; DDX39B; OAS2; KPNA2; IRAK4; PIK3CD

Protein Function

TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CCL6; LEFTY2; IFNA4; BMP8B; IL17C; PRL7D1; IFNA21; TNFSF18; IFNG1-2; GDF3
Function metal ion binding
Related Protein RSAD2; TRIM35-35; GTSF1; KCNIP3B; CA15B; NRXN3A; HIVEP2; PAPD7; UQCRC2B; GTPBP6
Function protein binding
Related Protein PLEKHG4; TULP1; NHLRC2; HIST2H4; HADHB; CD19; COX17; MID1IP1; ZMAT4; SERTAD3
Function receptor binding
Related Protein NRG2; HACL1; FGF10A; CSNK2B; HSPA1B; Ren1; LYN; P2RX4; NUDT19; PTK6B
Function tumor necrosis factor receptor binding
Related Protein TNFSF9; TNFSF10L3; TNFSF11; TRADD; TRAF2; Fasl; FASLG; CD70; ERAP1; TRAP1

Interacting Protein

TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.
TNFRSF10B

TNFSF10 Related Articles

Cantarella, G; Di Benedetto, G; et al. Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease. BRAIN 138:203-216(2015).
Goere, D; Flament, C; et al. Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab. CANCER RESEARCH 73:4663-4673(2013).

TNFSF10 Related Gene Family

TNF Cytokines