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TNFSF12

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 12

  • Overview

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
  • Synonyms

    TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; APO3L; DR3LG; TWEAK;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mouse
  • C
  • His
  • Fc
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • FLAG
  • SUMO
  • Met|His
  • mFc
  • N/A
  • RlgG Fc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF12-8461H Active Recombinant Human TNFSF12 E.coli N/A
Human TNFSF12-70H Active Recombinant Human TWEAK, FLAG-tagged E.coli Flag
Human TNFSF12-943H Active Recombinant Human TNFSF12 protein, mFc-tagged HEK293 mFc Ser94-His249
Human TNFSF12-1068H Recombinant Human TNFSF12 protein, His-tagged E.coli His Asp65~Gln247 (Accession # O43508)
Human TNFSF12-2097H Recombinant Human TNFSF12, FLAG-tagged E.coli Flag
Human TNFSF12-565H Recombinant Human TNFSF12 E.coli N/A
Human TNFSF12-200T Active Recombinant Human TNFSF12 Protein CHO
Human TNFSF12-3282H Recombinant Human TNFSF12 protein, His-tagged E.coli His 1-134 aa
Human DMABT-H18373 Mouse Anti-TNFSF12 Monoclonal Antibody Mouse N/A
Human TNFSF12-3605H Recombinant Human TNFSF12 protein, His-SUMO-tagged E.coli His-SUMO 43-249aa
Human TNFSF12-3216H Recombinant Human TNFSF12 Protein (Asp65-Gln247), His tagged E.coli His Asp65-Gln247
Human TNFSF12-01H Recombinant Human TNFSF12 Protein, His/FLAG-tagged HEK293T His/FLAG A106-H249
Human TNFSF12-305H Active Recombinant Human TNFSF12 Protein (Lys56-His249), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys56-His249
Mouse Tnfsf12-983M Active Recombinant Mouse Tnfsf12 Protein, Met & His-tagged E.coli Met/His Arg105-His249
Mouse Tnfsf12-01M Active Recombinant Mouse Tnfsf12 Protein, His-Tagged E.coli His
Mouse TNFSF12-17173M Recombinant Mouse TNFSF12 Protein Mammalian Cell His
Mouse Tnfsf12-196M Recombinant Mouse Tnfsf12, FLAG-tagged HEK293 Flag
Mouse Tnfsf12-1069M Recombinant Mouse Tnfsf12 protein, His-tagged E.coli His Gln53~His249
Mouse Tnfsf12-852M Recombinant Mouse Tnfsf12 Protein, Fc-tagged HEK293 Fc
Mouse TNFSF12-9483M-B Recombinant Mouse TNFSF12 Protein Pre-coupled Magnetic Beads HEK293
Mouse TNFSF12-9483M Recombinant Mouse TNFSF12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFSF12-810M Recombinant Mouse TNFSF12 Protein (Arg105-His249), RlgG Fc-tagged HEK293 RlgG Fc Arg105-His249
Mouse Tnfsf12-86M Active Recombinant Mouse Tnfsf12 Protein (His110-His249), C-His tagged, Animal-free, Carrier-free E.coli C-His His110-His249
Rat Tnfsf12-8728R Recombinant Rat Tnfsf12, Fc tagged Human Cell GST
Rat TNFSF12-1204RCL Recombinant Rat TNFSF12 cell lysate Human Cell N/A
Rat TNFSF12-0261R Active Recombinant Rat TNFSF12 protein, hFc-tagged HEK293 hFc Arg105-His249
Cynomolgus Monkey TNFSF12-8822C Recombinant Cynomolgus TNFSF12, Fc tagged Human Cell Fc/His
Cynomolgus Monkey TNFSF12-1155CCL Recombinant Cynomolgus TNFSF12 cell lysate Human Cell N/A
Homo sapiens (Human) RFL27494HF Recombinant Full Length Human Tumor Necrosis Factor Ligand Superfamily Member 12(Tnfsf12) Protein, His-Tagged E.coli expression system His Full Length (1-249)
Mus musculus (Mouse) RFL22909MF Recombinant Full Length Mouse Tumor Necrosis Factor Ligand Superfamily Member 12(Tnfsf12) Protein, His-Tagged E.coli expression system His Full Length (1-249)
Rhesus Macaque TNFSF12-4872R Recombinant Rhesus monkey TNFSF12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFSF12-4686R-B Recombinant Rhesus Macaque TNFSF12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNFSF12-4686R Recombinant Rhesus Macaque TNFSF12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TNFSF12-4501Z Recombinant Zebrafish TNFSF12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFSF12 Related Articles
  • TNFSF12 Related Gene Family
  • TNFSF12 Related Research Area
  • TNFSF12 Related Signal Pathway

TNFSF12 involved in several pathways and played different roles in them. We selected most pathways TNFSF12 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionEDAR;CXCR5;CSF2;IRX1;TP-1;CCR7;CXCL2;EPOR;TNFRSF10C

TNFSF12 has several biochemical functions, for example, cytokine activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF12 itself. We selected most functions TNFSF12 had, and list some proteins which have the same functions with TNFSF12. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCTF1;TNFSF4;TXLNA;CSF2;CCL20A.3;IFNA21;CMTM7;BMP15;Fasl
protein bindingZWILCH;TGIF2LY;COX5A;CCDC87;PRLHR;CRTC2;SYNJ2;HER5;GZMA
receptor bindingFGF13A;FGF8B;CNPY3;ABL1;APOL2;ADM;SRI;GUSB;SRMS
tumor necrosis factor receptor bindingTNFSF9;ERAP1;TNFSF4;TNFB;EDA;TNFSF13B;CASP8;BRE;FASLG

TNFSF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF12.

Sastre, C; Fernandez-Laso, V; et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:721-734(2014).
Zhou, H; Hittelman, WN; et al. Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors. CANCER RESEARCH 73:4439-4450(2013).
TNF
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