tnfsf12
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 12
  • Background
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
  • Synonyms
  • TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; APO3L; DR3LG; TWEAK
Cat.#:TNFSF12-810MTag:RlgG Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFSF12 Protein (Arg105-His249), RlgG Fc-tagged
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Cat.#:TNFSF12-565HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF12
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Cat.#:TNFSF12-1068HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF12 protein, His-tagged
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Cat.#:TNFSF12-2097HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF12, FLAG-tagged
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Cat.#:TNFSF12-70HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TWEAK, FLAG-tagged
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Cat.#:TNFSF12-8461HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF12
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Cat.#:Tnfsf12-1069MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf12 protein, His-tagged
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Cat.#:TNFSF12-17173MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNFSF12 Protein
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Cat.#:Tnfsf12-196MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf12, FLAG-tagged
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Cat.#:Tnfsf12-852MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf12 Protein, Fc-tagged
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Cat.#:Tnfsf12-983MTag:Met/His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf12 Protein, Met & His-tagged
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Cat.#:Tnfsf12-8728RTag:GST
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tnfsf12, Fc tagged
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Cat.#:TNFSF12-8822CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF12, Fc tagged
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Cat.#:TNFSF12-4872RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TNFSF12 Protein, His-tagged
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Cat.#:TNFSF12-4501ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TNFSF12
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Cat.#:TNFSF12-1204RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TNFSF12 cell lysate
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Cat.#:TNFSF12-1155CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF12 cell lysate
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Involved Pathway

TNFSF12 involved in several pathways and played different roles in them. We selected most pathways TNFSF12 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL19; IL12A; CRFB4; IL4R; TNFRSF8; CCL11; CXCL6; BMPR1BB; KITA; PDGFA

Protein Function

TNFSF12 has several biochemical functions, for example, cytokine activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF12 itself. We selected most functions TNFSF12 had, and list some proteins which have the same functions with TNFSF12. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GDF1; GDF11; BMP1; IL20; IFNA12; HMGB1; GPI; GDF3; ADIPOQ; AREG
Function protein binding
Related Protein RAB11FIP3; LYRM2; CHUK; FERD3L; CCK; NEDD8; APLP1; BATF2; CUL9; UGGT1
Function receptor binding
Related Protein CHRNA10; TNFSF15; FKBP1B; HFE2; NXPH1; HAO2; SLC9A3R2; DRD1A; MSN; ANGPTL2
Function tumor necrosis factor receptor binding
Related Protein TNFSF12; LTA; TNFSF10L; ERAP1; TRAF1; TRAF4; TNFSF13B; EDA; TNFSF8; TRADD

TNFSF12 Related Articles

Sastre, C; Fernandez-Laso, V; et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:721-734(2014).
Zhou, H; Hittelman, WN; et al. Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors. CANCER RESEARCH 73:4439-4450(2013).

TNFSF12 Related Gene Family

TNF