tnni3
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  • Official Full Name
  • troponin I type 3 (cardiac)
  • Background
  • Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive);
Cat.#:Tnni3-1003HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human cTnI Protein
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Cat.#:TNNI3-2254HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNNI3 Protein, MYC/DDK-tagged
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Cat.#:Tnni3-1388MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tert Protein, His-SUMO-tagged
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Cat.#:TNNI3-164HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TNNI3 Protein, DDK-tagged
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Cat.#:TNNI3-181HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3 protein
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Cat.#:TNNI3-18HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3 protein, His-tagged
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Cat.#:TNNI3-27225THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3
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Cat.#:TNNI3-27226THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3
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Cat.#:TNNI3-31690THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3
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Cat.#:TNNI3-52HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI3 protein, His-tagged
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Cat.#:TNNI3-79HTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TNNI3
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Cat.#:TNNI3-17196MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNNI3 Protein
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Cat.#:Tnni3-17MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnni3 protein, His-tagged
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Cat.#:Tnni3-2674MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnni3 protein, His-tagged
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Cat.#:Tnni3-179RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnni3 protein, His-tagged
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Cat.#:Tnni3-2676RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnni3 protein, His-tagged
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Cat.#:TNNI3-6209RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNNI3 Protein
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Cat.#:TNNI3-178DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TNNI3 protein, His/T7-tagged
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Cat.#:TNNI3-7123CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNNI3
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Cat.#:TNNI3-2675PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TNNI3 protein, His & T7-tagged
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Cat.#:TNNI3-220HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Troponin I Type 3 (Cardiac)
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Cat.#:TNNI3-27665HTag:His
Source (Host):Species:Human
Product nameRecombinant Human TNNI3, His-tagged
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Cat.#:TNNI3-221HTag:
Source (Host):Species:Human
Product nameNative Human TNNI3
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Cat.#:TNNI3-223HTag:N/A
Source (Host):Human heart tissueSpecies:Human
Product nameNative Human Troponin I Type 3 (Cardiac)
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Cat.#:TNNI3-1803HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNNI3 cell lysate
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Involved Pathway

TNNI3 involved in several pathways and played different roles in them. We selected most pathways TNNI3 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
PLD2; PDE3A; CAMK2B; PTCH1; GRIN2A; MAPK8; PRKACB; HCAR3; CNGA2; GRIN2C
Cardiac muscle contraction
ATP1A2; RYR2; CACNB2A; TPM4; UQCRC2; COX4I1; CACNA2D1A; ATP1A1A.1; MYL2; ATP1A1B
Adrenergic signaling in cardiomyocytes
CACNA2D1A; CACNB2; AKT2; PPP1CA; CACNA1DA; PIK3R3B; TNNT2A; PIK3CD; ATF6B; PPP2R5D
Hypertrophic cardiomyopathy (HCM)
ACE; MYL3; CACNG7; ITGA5; TPM2; ITGA6; ITGB4; PRKAG1; CACNG4; CACNB2
Dilated cardiomyopathy
DES; ITGA3; ACTG1; TPM1; MYL2; CACNB4; ITGB7; SLC8A1; TGFB2; CACNG7

Protein Function

TNNI3 has several biochemical functions, for example, actin binding, calcium channel inhibitor activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI3 itself. We selected most functions TNNI3 had, and list some proteins which have the same functions with TNNI3. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein EPB49; HIP1R; PARVAA; CXCR4; KCNMA1; SPIRE2; MYHZ1.2; SMYHC2; SPTB; VMHC
Function calcium channel inhibitor activity
Related Protein ITPR1; PACSIN3; TNNI3; SLC30A1; CCDC109B; AMBP; SLC30A1A; STX1A; SLC30A1B; FKBP1B
Function calcium-dependent protein binding
Related Protein MYO1D; ANXA3; S100A4; NELF; MMP13; C9orf9; SLC9A1; ANXA7; ANXA4; ANXA1
Function metal ion binding
Related Protein ZNF671; RCV1; KDM2BA; SALL3B; OSR2; ZNF334; DDR1; PIKFYVE; PHF23B; C6AST4
Function protein binding
Related Protein SYT1; USP37; LOXL4; GATA1; SPTA1; LRP6; GATA4; CARF; APOO; MPHOSPH8
Function protein domain specific binding
Related Protein STAMBP; IL1B; CTBP1; YWHAE2; WNT3; GABRR1; GABRR3; TFDP2; RAB27A; HMGB2
Function protein kinase binding
Related Protein PTPRR; AKAP7; APC; HDAC4; FAF1; CADPS; NSF; CCNL1B; CDK5RAP3; TPX2
Function troponin C binding
Related Protein TNNI3; TNNT3
Function troponin T binding
Related Protein TNNT1; TNNI2; TNNI3; TNNC1

Interacting Protein

TNNI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI3.
RCAN3; RCAN3; TNNI3K; PDE4DIP; TNNC1; TNNI3K; TRIM21; TRIM63; SMURF2