TNNI3

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TNNI3

Official Full Name troponin I type 3 (cardiac)
Background Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Synonyms TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive);
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cardiac
    • Human Heart
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • DDK
    • His
    • SUMO
    • T7
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human Tnni3-1003H Recombinant Human cTnI Protein E.coli His
    Human TNNI3-164H Recombinant Human TNNI3 Protein, DDK-tagged Insect Cell DDK
    Human TNNI3-1803HCL Recombinant Human TNNI3 cell lysate N/A
    Human TNNI3-181H Recombinant Human TNNI3 protein E.coli N/A
    Human TNNI3-18H Recombinant Human TNNI3 protein, His-tagged E.coli His
    Human TNNI3-220H Recombinant Human Troponin I Type 3 (Cardiac) E.coli N/A
    Human TNNI3-221H Native Human TNNI3 Human Cardiac N/A
    Human TNNI3-223H Native Human Troponin I Type 3 (Cardiac) Human Heart N/A
    Human TNNI3-2254H Recombinant Human TNNI3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNNI3-27225TH Recombinant Human TNNI3 E.coli N/A
    Human TNNI3-27226TH Recombinant Human TNNI3 E.coli N/A
    Human TNNI3-27665H Recombinant Human TNNI3, His-tagged E.coli His
    Human TNNI3-31690TH Recombinant Human TNNI3 E.coli N/A
    Human TNNI3-52H Recombinant Human TNNI3 protein, His-tagged E.coli His
    Human TNNI3-79H Recombinant Human TNNI3 Insect Cell N/A
    Mouse Tnni3-1388M Recombinant Mouse Tert Protein, His-SUMO-tagged E.coli His/SUMO
    Mouse TNNI3-17196M Recombinant Mouse TNNI3 Protein Mammalian Cell His
    Mouse Tnni3-17M Recombinant Mouse Tnni3 protein, His-tagged E.coli His
    Mouse Tnni3-2674M Recombinant Mouse Tnni3 protein, His-tagged E.coli His
    Rat Tnni3-179R Recombinant Rat Tnni3 protein, His-tagged E.coli His
    Rat Tnni3-2676R Recombinant Rat Tnni3 protein, His-tagged E.coli His
    Rat TNNI3-6209R Recombinant Rat TNNI3 Protein Mammalian Cell His
    Dog TNNI3-178D Recombinant Dog TNNI3 protein, His/T7-tagged E.coli His/T7
    Chicken TNNI3-7123C Recombinant Chicken TNNI3 Mammalian Cell His
    Pig TNNI3-2675P Recombinant Pig TNNI3 protein, His & T7-tagged E.coli His/T7

    TNNI3 involved in several pathways and played different roles in them. We selected most pathways TNNI3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway CALM4; GABBR1; CREB3L3; GPR81; CAMK2G; BAD; MAPK3; CALML3; Adcy4; GLP1R
    Cardiac muscle contraction COX6A1; TNNC1A; TPM4A; ATP1B2A; CACNG1; TNNT2; COX5B2; CACNA2D1; COX6B1; CACNG2
    Adrenergic signaling in cardiomyocytes ATP1A2; GNAI2A; CAMK2B1; MYL3; CREB5; ADCY7; PPP1CC; CALM; CACNG7; ACTC1B
    Hypertrophic cardiomyopathy (HCM) ACE; PRKAG1; CACNG4; IGF1; CACNB2; CACNG7; TTN; ACTC1; DES; DMD
    Dilated cardiomyopathy ITGA8; MYH7; ACTG1; MYBPC3; CACNB4; PRKACA; SGCD; CACNG3; SLC8A1; CACNG2

    TNNI3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI3 itself. We selected most functions TNNI3 had, and list some proteins which have the same functions with TNNI3. You can find most of the proteins on our site.

    Function Related Protein
    actin binding MYBPC3; MICAL2B; SVILA; CAPZA3; HIP1R; GSNA; Fert2; WASL; FRG1; YWHAH
    calcium channel inhibitor activity STX1A; FKBP1AA; PACSIN3; PHPT1; FKBP1B; TNNI3; ITPR1; CCDC109B; FKBP1AB; SLC30A1B
    calcium-dependent protein binding ANXA6; ANXA11; KOP; MBL1; SNAP25; MYO1D; NRXN1; CALM3; ANXA2; CD209A
    metal ion binding SIAH2L; CDK5RAP1; CYP2X8; ZNF653; CYP4A10; PLEKHM1; KLF9; CYP3C1; ARL3; PRPSAP2
    protein binding MED10; MAPKBP1; TMPRSS2; COL3A1; NR0B1; B2M; PLEKHF1; FSHR; CXADR; SPRYD7
    protein domain specific binding STMN3; TFDP2; HIST1H4C; ACTN2; RQCD1; FOXA3; PLAUR; MPP5; CNTLN; HOMER3
    protein kinase binding GSTP2; IL31RA; CYLD; CENPJ; KAT2B; B4GALT1; AXIN1; PRKACA; MSN; FOXO3
    troponin C binding TNNT3; TNNI3
    troponin T binding TNNI3; TNNI2; TNNC1; TNNT1

    TNNI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI3.

    RCAN3; RCAN3; TNNI3K; PDE4DIP; TNNC1; TNNI3K; TRIM21; TRIM63; SMURF2

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