Tlr4
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Official Full Name
toll-like receptor 4
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Overview
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. -
Synonyms
TLR4; toll-like receptor 4; Lps; Ly87; Ran/M1; Rasl2-8; lipopolysaccharide response;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Goat
- Human
- Mouse
- Rat
- Rhesus Macaque
- Rhesus monkey
- Baculovirus-Insect cells
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Fc
- His
- Strep
- DYKDDDDK
- Flag
- GST
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|S
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Ser|His
- Involved Pathway
- Protein Function
- Interacting Protein
- Tlr4 Related Research Area
Tlr4 involved in several pathways and played different roles in them. We selected most pathways Tlr4 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
NF-kappa B signaling pathway | IL-8;TRAF1;LTA;TRAF3;CFLAR;PLAU;GM13304;NFKBIA;LYN |
HIF- signaling pathway | PRKCG;SLC2A1;MAPK3;ANGPT1;TEK;EGLN1;PIK3R5;PIK3R1;VHL |
Phagosome | ATP6V0CB;TUBA1B;ITGB1B.2;TUBA8L2;RILP;Cd209g;CD209B;ITGAM;CD14 |
PIK-Akt signaling pathway | PDGFB;PRKAA2;YWHAZ;GNB2;GNG13;IFNA5;Il4ra;TSC1;SYK |
Toll-like receptor signaling pathway | PIK3R5;MAPK12B;IFNA13;MAPK8;CD40;CASP8;CCL5;Ifna11;MAP2K4B |
Pathogenic Escherichia coli infection | ARPC5L;NCK2;RHOA;ARHGEF2;TUBA8;TUBB2B;TUBA3D;TUBA3E;TUBA1C |
Salmonella infection | TLR4BB;CDC42L2;RAC1A;MAPK1;TLR4;TLR5B;FOS;ARPC4L;KLC1 |
Pertussis | C2;NFKB1;C1S;C4BPA;IL-8;AMCF-II;GNAI3;ITGB2L;MAPK10 |
Legionellosis | NFKBIA;VCP;NAIP1;HSPA1B;Itgam&Itgb2;TLR4;HSPD1;RAB1;CD14 |
Leishmaniasis | HLA-DRB1;PRKCB;TLR4;NCF1;NFKB1;NCF4;MARCKSL1;FCGR4;IL1A |
Chagas disease (American trypanosomiasis) | MAP2K4;IL1B2;PIK3CB;MAPK9;FADD;RELA;CCL3;TRAF6;SERPINE1 |
Malaria | TNF;ITGB2;SDC2;IFNG;TGFB2;THBS4;HBB-B2;CD81;SELP |
Toxoplasmosis | MAP2K3;STAT3;BIRC8;IL10RB;PIK3R2;GNAI3;HLA-DOA;BIRC2;STAT1 |
Amoebiasis | ARG2;IL-8;LAMA3;GNAQ;TLR4;IL12A;RAB7B;LAMB3;SERPINB10 |
Tuberculosis | SRC;CALM3;ARHGEF12;CORO1A;CD209C;RAF1;HLA-DOA;TNFRSF1A;HLA-DQA2 |
Hepatitis B | TLR2;BAX;EGR3;PIK3CB;BIRC5;NFATC2;IFNA6;STAT6;YWHAB |
Measles | IFNA12;IFNA21;TAB2;OAS1;HSPA1A;FYN;EIF2AK1;MYD88;CD46 |
Influenza A | Ccl12;RSAD2;PRKCB;LOC100033925;GSK3B;MAVS;PRSS3;CCL2;IFNA3 |
Proteoglycans in cancer | ROCK2;CDC42;HPSE2;PIK3CD;CAMK2B;PPP1CA;ACTB;NANOG;PDCD4 |
Inflammatory bowel disease (IBD) | FOXP3;IL22;STAT3;IL17A;IFNGR1;IL1B;IL18R1;NFATC1;Il2 |
Rheumatoid arthritis | ITGB2L;FLT1;CXCL5;HLA-DQA2;CD28;FOS;CCL3L3;TGFB1;CCL5 |
Tlr4 has several biochemical functions, for example, lipopolysaccharide binding, lipopolysaccharide receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr4 itself. We selected most functions Tlr4 had, and list some proteins which have the same functions with Tlr4. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
lipopolysaccharide binding | CD14;DROSHA;TREM2;CATHL3;LBP;CD6;TLR2;HSPD1;SCARB1 |
lipopolysaccharide receptor activity | PTAFR;TLR4;LY96;TLR2;SCARB1 |
protein binding | IRAK1;FBXO6;CCND3;TOR1A;TRIM37;TFPT;JAG1;FAM104A;SPC24 |
receptor activity | GFRA1A;GUCY1A3;ITGB1A;CRLF1;RAMP3;LILRA2;CD7;LILRB2;RET |
transmembrane signaling receptor activity | ADCYAP1R1A;OR6K3;FZD1;Cd79a, Cd79b;GABRQ;TLR3;CELSR3;EDAR;TLR2-1 |
Tlr4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr4.
LY96; TIRAP; o76552_acavi; eritoran tetrasodium; BGN; PAUF; LY96; EGFR; HMGB1; F2RL1; TICAM2
- Q&As
- Reviews
Q&As (5)
Ask a questionTLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.
Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.
The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.
TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.
TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.
Customer Reviews (3)
Write a reviewPrecision in every experiment—this product is a game-changer for us.
Timely delivery is key, and this product arrived on schedule.
Exceptional customer service—knowledgeable staff guided us through the selection process.
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