tlr4
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  • Official Full Name
  • toll-like receptor 4
  • Background
  • Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
  • Synonyms
  • TLR4; toll-like receptor 4; Lps; Ly87; Ran/M1; Rasl2-8; lipopolysaccharide response;
Cat.#:TLR4-289HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TLR4, MYC/DDK-tagged
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Cat.#:TLR4-290HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human TLR4, His-tagged
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Cat.#:TLR4-291HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TLR4, GST-tagged
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Cat.#:TLR4-292HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TLR4, GST-tagged
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Cat.#:TLR4-293HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TLR4
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Cat.#:TLR4-296HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human TLR4/LY96 Complex Protein, His-tagged
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Cat.#:TLR4-29825THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TLR4
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Cat.#:TLR4-7275HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLR4, His tagged
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Cat.#:TLR4-7617HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR4 protein, His & S-tagged
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Cat.#:TLR4-7618HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR4 protein, His & T7-tagged
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Cat.#:TLR4-886HTag:Ser|His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human TLR4 Protein, Ser & His-tagged
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Cat.#:TLR4-887HTag:N/A
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human TLR4
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Cat.#:TLR4-16826MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TLR4 Protein
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Cat.#:Tlr4-7619MTag:His|S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr4 protein, His & S-tagged
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Cat.#:TLR4-6084RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TLR4 Protein
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Cat.#:Tlr4-7620RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tlr4 protein, His-tagged
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Cat.#:TLR4-1673RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR4 Protein
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Cat.#:TLR4-1674RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR4 Protein, hIgG1-tagged
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Cat.#:TLR4-1675RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR4 Protein, hIgG4-tagged
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Cat.#:TLR4-4733RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR4 Protein, His-tagged
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Cat.#:TLR4-2396CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLR4
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Cat.#:Tlr4-2432MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Toll-like Receptor 4, Fc Chimera
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Cat.#:TLR4-402HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLR4 cell lysate
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Involved Pathway

Tlr4 involved in several pathways and played different roles in them. We selected most pathways Tlr4 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
IL-8; PTGS2; Ccl21c; CXCL12; TNFSF11; CD40LG; NFKB2; NFKBIA; BCL10; TNFSF13B
HIF- signaling pathway
EIF4E2; VEGFA; PFKFB3; RELA; AKT2; RPS6KB1; PIK3R5; TFRC; PIK3CG; ANGPT2
Phagosome
ACTG1; FCGR1A; RAB5AA; TLR4BB; DYNC1LI1; THBS2; ATP6V0A4; HLA-DPA1; HGS; SEC61A1
PIK-Akt signaling pathway
GRB2; IFNA17; Reln; PDGFB; ITGA2; FGFR1; FN1; FGF18; BCL2; LAMA3
Toll-like receptor signaling pathway
MAP2K7; CCL3; MAP2K2; IFNA5; IFNB; IFNA16; IFNPHI1; FADD; PIK3R3B; NFKBIAB
Pathogenic Escherichia coli infection
CDH1; TUBB7P; OCLN; ACTG1; NCK2; TLR5; ROCK1; ROCK2; ARHGEF2; TUBB6
Salmonella infection
RAB7; KLC2; ARPC5L; TJP1; DYNC2H1; IFNGR1; NOS2; PYCARD; MAPK13; KLC1B
Pertussis
NLRP3; Itgam&Itgb2; IL23; CASP7; TLR4; FOS; ITGB2; C1QA; GNAI1; MAPK12
Legionellosis
BNIP3; HSPA1A; IL1B; EEF1G; NAIP1; HSF1; RELA; TLR5; VCP; EEF1A1
Leishmaniasis
TGFB1; C3; HLA-DRB1; TNF; MAPK3; MAPK1; ELK1; TLR4; NCF4; FCGR1A
Chagas disease (American trypanosomiasis)
CD3E; MAPK10; PLCB2; PIK3CB; IL6; IL12B; AKT2; MAPK9; FASLG; CD3E; CD3D
Malaria
IFNG; SELE; ITGB2L; CSF3; HBA2; GYPA; HBB; TLR4; MET; IL1B
Toxoplasmosis
GNAO1; HLA-DQB1; IFNGR1; IRAK4; IL10RA; BIRC3; SOCS1; MAPK8; IKBKB; NFKBIB
Amoebiasis
ACTN1; RAB7A; PLCB4; CD1D; SERPINB13; C8G; IL1R1; PTK2; GNA14; CXCL1
Tuberculosis
PIK3C3; CAMP; RAB5B; PPP3CB; IFNA5; CALM1; PPP3CA; ARHGEF12; IL12B; TRADD
Hepatitis B
HRAS; RAF1; PRKCA; IFNA12; NFATC2; STAT3; IFNA10; PTEN; RB1; CCNE2
Measles
TNFAIP3; CD209A; IFNA21; IFNA4; TACR1; IFNA2; IFNA13; IL2RG; Cd209g; FCGR2B
Influenza A
IFNB1; IFNA17; HSPA2; MAPK1; SOCS3; HLA-DQB1; CASP9; PIK3CG; STAT2; CCL2
Proteoglycans in cancer
FASLG; PPP1CA; PRKCB; CAV1; TP53; NUDT16L1; TGFB2; HPSE; Fzd4; WNT3A
Inflammatory bowel disease (IBD)
IL12B; HLA-DRA; IL18RAP; TGFB2; IL1B; HLA-DRB3; HLA-DRB4; TNF; TLR4; STAT6
Rheumatoid arthritis
ATP6V0B; TNFSF13; ATP6V0A4; Ctsl; CCL3; CXCL6; ATP6V1D; Ccl12; GM-CSF; CD86

Protein Function

Tlr4 has several biochemical functions, for example, lipopolysaccharide binding, lipopolysaccharide receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr4 itself. We selected most functions Tlr4 had, and list some proteins which have the same functions with Tlr4. You can find most of the proteins on our site.
Function
Related Protein
Function lipopolysaccharide binding
Related Protein SPON2; CD14; P2RX7; SELP; LBP; PTAFR; CATHL3; TRIL; TREM2; HSPD1
Function lipopolysaccharide receptor activity
Related Protein TLR4; TLR2; SCARB1; LY96; PTAFR
Function protein binding
Related Protein TMEM183A; ZBTB7B; OCIAD1; DNAJC19; HSP90AA1.2; KLK15; FYTTD1; C12orf40; PSMB2; CSF1
Function receptor activity
Related Protein TLR2; ANXA2R; MRC1; MED30; TREM1; PVRL4; PVRL2L; VMN1R52; NLGN2; SLC20A2
Function transmembrane signaling receptor activity
Related Protein SEMA4D; ICAM1; MRC1; OR4F29; GIPR; LGR4; CLDN3; IGSF6; CD79B; GP1BB

Interacting Protein

Tlr4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr4.
LY96; TIRAP; o76552_acavi; eritoran tetrasodium; BGN; PAUF; LY96; EGFR; HMGB1; F2RL1; TICAM2