Recombinant Human BMPR1A Protein (177-532 aa), His-SUMO-tagged

• Cat.No.: BMPR1A-361H
• Product Overview: Recombinant Human BMPR1A Protein (177-532 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial.

Specification

• Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmbrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction.
• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 56.6 kDa
• Protein length: 177-532 aa
• AA Sequence: KHYCKSISSRRRYNRDLEQDEAFIP VGESLKDLIDQSQSSGSGSGLPLLV QRTIAKQIQMVRQVGKGRYGEVWMG KWRGEKVAVKVFFTTEEASWFRETE IYQTVLMRHENILGFIAADIKGTGS WTQLYLITDYHENGSLYDFLKCATL DTRALLKLAYSAACGLCHLHTEIYG TQGKPAIAHRDLKSKNILIKKNGSC CIADLGLAVKFNSDTNEVDVPLNTR VGTKRYMAPEVLDESLNKNHFQPYI MADIYSFGLIIWEMARRCITGGIVE EYQLPYYNMVPSDPSYEDMREVVCV KRLRPIVSNRWNSDECLRAVLKLMS ECWAHNPASRLTALRIKKTLAKMVE SQDVKI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
• Official Symbol: BMPR1A
• Synonyms: BMPR1A; ACVRLK3; ALK3; CD292; ALK-3; BMPR-1A; SKR5; 10q23del
• Gene ID: 657
• mRNA Refseq: NM_004329
• Protein Refseq: NP_004320
• MIM: 601299
• UniProt ID: P36894

Reviews

11/06/2021

The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

10/20/2021

When experimenting with this protein, stable and repeatable results can be obtained.

03/08/2021

This product has strict quality control and complies with relevant industry standards.

Q&As

What disease might abnormal BMPR1A levels suggest?

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A?

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed?

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A?

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment?

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause?

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.