Recombinant Human BMPR1A Protein (177-532 aa), His-SUMO-tagged

• Cat.No.: BMPR1A-361H
• Product Overview: Recombinant Human BMPR1A Protein (177-532 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial.

Specification

• Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmbrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 56.6 kDa
• Protein length: 177-532 aa
• AA Sequence: KHYCKSISSRRRYNRDLEQDEAFIP VGESLKDLIDQSQSSGSGSGLPLLV QRTIAKQIQMVRQVGKGRYGEVWMG KWRGEKVAVKVFFTTEEASWFRETE IYQTVLMRHENILGFIAADIKGTGS WTQLYLITDYHENGSLYDFLKCATL DTRALLKLAYSAACGLCHLHTEIYG TQGKPAIAHRDLKSKNILIKKNGSC CIADLGLAVKFNSDTNEVDVPLNTR VGTKRYMAPEVLDESLNKNHFQPYI MADIYSFGLIIWEMARRCITGGIVE EYQLPYYNMVPSDPSYEDMREVVCV KRLRPIVSNRWNSDECLRAVLKLMS ECWAHNPASRLTALRIKKTLAKMVE SQDVKI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
• Official Symbol: BMPR1A
• Synonyms: BMPR1A; ACVRLK3; ALK3; CD292; ALK-3; BMPR-1A; SKR5; 10q23del
• Gene ID: 657
• mRNA Refseq: NM_004329
• Protein Refseq: NP_004320
• MIM: 601299
• UniProt ID: P36894