Recombinant Mouse Bone Morphogenetic Protein Receptor, Type 1A

• Cat.No.: Bmpr1a-1709M

Specification

• Cat. No.: Bmpr1a-1709M
• Description: Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR-1A), also known as activin receptor-like kinase (ALK)-3, is a monomeric glycoprotein and is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-β family cytokines. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity. BMPRIA immunohistochemistry may be a promising new tool for the identification of enteric ganglion cells in the evaluation of patients with neurointestinal disorders.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse BMPR-IA is Mr 41.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus ]
• Synonyms: Bmpr1a; bone morphogenetic protein receptor, type 1A; ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik; EC 2.7.11.1; EC 2.7.11.30
• Gene ID: 12166
• mRNA Refseq: NM_009758
• Protein Refseq: NP_033888
• UniProt ID: P36895
• Chromosome Location: 14 B; 14 13.0 cM
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity