Recombinant Human BMPR1A Protein, GST-tagged
Cat.No. : | BMPR1A-281H |
Product Overview : | Human BMPR1A (NP_004320.2, 187 a.a. - 532 a.a.) Q223D mutant partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells. |
- Specification
- Gene Information
- Related Products
Description : | The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq |
Source : | Sf21 cells |
Species : | Human |
Tag : | GST |
Form : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol) |
Molecular Mass : | 66 kDa |
Purity : | 60 % by SDS-PAGE/CBB staining |
Quality Control Test : | Loading 1 ug protein in SDS-PAGE |
Notes : | Result of activity analysis |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol) |
Gene Name : | BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ] |
Official Symbol : | BMPR1A |
Synonyms : | BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5; SKR5; 10q23del; |
Gene ID : | 657 |
mRNA Refseq : | NM_004329 |
Protein Refseq : | NP_004320 |
MIM : | 601299 |
UniProt ID : | P36894 |
Products Types
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Bmpr1a-10524M | Recombinant Mouse Bmpr1a Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR1A-361H | Recombinant Human BMPR1A Protein (177-532 aa), His-SUMO-tagged | +Inquiry |
BMPR1A-107H | Recombinant Human BMPR1A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
BMPR1A-2145HCL | Recombinant Human BMPR1A cell lysate | +Inquiry |
BMPR1A-2466MCL | Recombinant Mouse BMPR1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAbnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.
The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.
Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.
Customer Reviews (3)
Write a reviewThe enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.
When experimenting with this protein, stable and repeatable results can be obtained.
This product has strict quality control and complies with relevant industry standards.
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