CCR2

  • Official Full Name

    chemokine (C-C motif) receptor 2

  • Overview

    This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
  • Synonyms

    CCR2; chemokine (C-C motif) receptor 2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; FLJ78302; MGC103828; MGC111760; MGC168006; C-C CKR-2; OTTHUMP00000209948;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • hFc
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
  • C
  • Myc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR2-15HB Active Recombinant Human CCR2 protein, Biotinylated HEK293 N/A Met1-Ala374
Human CCR2-3954H Active Recombinant Human CCR2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CCR2-15H Active Recombinant Human CCR2 protein HEK293 N/A Met1-Ala374
Human CCR2-135H Recombinant Human CCR2 Protein Wheat Germ N/A
Human CCR2-0689H Recombinant Human CCR2 Protein, GST-Tagged Wheat Germ GST
Human CCR2-190H Recombinant Human CCR2 Protein Wheat Germ N/A
Human CCR2-1412H Recombinant Human CCR2 Protein Wheat Germ N/A
Human CCR2-27804TH Recombinant Human CCR2 Wheat Germ N/A 42 amino acids
Human CCR2-7696HCL Recombinant Human CCR2 293 Cell Lysate HEK293 N/A
Human CCR2-1072HFL Recombinant Human CCR2 protein, His&Flag-tagged HEK293 His&Flag 1-374 aa
Human CCR2-1735HF Recombinant Full Length Human CCR2 Protein In Vitro Cell Free System 374 amino acids
Human CCR2-1002HF Recombinant Full Length Human CCR2 Protein In Vitro Cell Free System 374 amino acids
Human CCR2-4392H Active Recombinant Human CCR2 Full Length Transmembrane protein(VLPs) HEK293 N/A Met1-Leu360
Human CCR2-921HF Recombinant Full Length Human CCR2 Protein In Vitro Cell Free System 374 amino acids
Human CCR2-4393H Active Recombinant Human CCR2 Full Length Transmembrane protein(VLPs), Biotinylated HEK293 N/A Met1-Leu360
Mouse CCR2-3014M Recombinant Mouse CCR2 Protein, His-tagged E.coli His
Mouse CCR2-3015M Recombinant Mouse CCR2 protein, hFc-tagged HEK293 hFc Met1-Ala55
Mouse Ccr2-4321M Recombinant Mouse Ccr2 protein, His&Myc-tagged E.coli N-His&C-Myc 1-55aa
Rat CCR2-1227R Recombinant Rat CCR2 Protein Mammalian Cell His
Rat CCR2-885R-B Recombinant Rat CCR2 Protein Pre-coupled Magnetic Beads HEK293
Rat CCR2-885R Recombinant Rat CCR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Monkey CCR2-705R Recombinant Rhesus Monkey CCR2 Protein, His-tagged E.coli His
Homo sapiens (Human) RFL10533HF Recombinant Full Length Human C-C Chemokine Receptor Type 2(Ccr2) (Active) Protein, His-Tagged E.coli expression system His Full Length (1-374aa)
Macaca mulatta (Rhesus macaque) RFL28107MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) C-C Chemokine Receptor Type 2(Ccr2) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Mus musculus (Mouse) RFL4539MF Recombinant Full Length Mouse C-C Chemokine Receptor Type 2(Ccr2) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Rattus norvegicus (Rat) RFL19268RF Recombinant Full Length Rat C-C Chemokine Receptor Type 2(Ccr2) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Chicken CCR2-3494C Recombinant Chicken CCR2 Mammalian Cell His
Kit-1637 CHO-K1 CCR2 Bioassay Kit N/A
Kit-1150 CCR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1638 CCR2 Total GPCR Internalization Assay Kit N/A
  • Other Resource

CCR2 involved in several pathways and played different roles in them. We selected most pathways CCR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CCR2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCR2 itself. We selected most functions CCR2 had, and list some proteins which have the same functions with CCR2. You can find most of the proteins on our site.

Function Related Protein

CCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR2.

Gene Family

GPCRs Chemokines Cytokines

Research Area

Related articles

Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
Srivastava, K; Hu, J; et al. Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth. CANCER CELL 26:880-895(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
06/03/2022

    This reproducibility of CCR2 was very good, showing good production process and quality control.

    12/10/2020

      I appreciate the attention paid to product quality by the producers of CCR2, and their product is very stable, which makes our experiments smoother.

      10/22/2019

        The bands of CCR2 in Western blot were regular in shape and showed good quality.

        Q&As (6)

        Ask a question
        Which drugs interact with CCR2 proteins? 12/30/2019

        Antagonists of multiple CCR2 proteins have been developed to inhibit the binding of CCR2 to its ligand CCL2, thereby regulating the inflammatory response and migration of immune cells.

        Does CCR2 protein research have implications for new drug development? 12/16/2019

        CCR2 protein plays an important role in the field of immune inflammation, and studying the function and regulatory mechanism of CCR2 protein will help the development of new drugs, for example, antagonists targeting CCR2 protein may be applied to the treatment of inflammatory diseases.

        What is the role of CCR2 protein in infectious diseases? 12/06/2019

        The CCR2 protein plays an important role in the migration and activation of macrophages and may therefore be involved in the initiation and progression of infectious diseases.

        Has a diagnostic method been developed to interact with the CCR2 protein? 06/08/2019

        There are no specific diagnostic methods for the CCR2 protein, but the CCR2 protein could be a potential candidate for inflammatory markers.

        What is the mechanism of action of CCR2 protein in inflammatory response? 05/18/2019

        By binding to its ligand CCL2, CCR2 protein regulates the release of inflammatory mediators, the migration of immune cells, and the occurrence of inflammatory responses.

        What are the potential applications of CCR2 protein in immune vaccine design? 05/05/2019

        CCR2 protein plays an important role in the activation and migration of immune cells, so it can be used in immune vaccine design to promote immune cell infiltration and antigen presentation.

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