ccr2

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ccr2

Official Full Name chemokine (C-C motif) receptor 2
Background This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
Synonyms CCR2; chemokine (C-C motif) receptor 2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; FLJ78302; MGC103828; MGC111760; MGC168006; C-C CKR-2; OTTHUMP00000209948
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Monkey
    • Source :
    • E. coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCR2-0689H Recombinant Human CCR2 Protein, GST-Tagged Wheat Germ GST
    Human CCR2-135H Recombinant Human CCR2 Protein Wheat Germ N/A
    Human CCR2-1412H Recombinant Human CCR2 Protein Wheat Germ N/A
    Human CCR2-190H Recombinant Human CCR2 Protein Wheat Germ N/A
    Human CCR2-27804TH Recombinant Human CCR2 Wheat Germ N/A
    Human CCR2-7696HCL Recombinant Human CCR2 293 Cell Lysate HEK293 N/A
    Mouse CCR2-3014M Recombinant Mouse CCR2 Protein, His-tagged E. coli His
    Rat CCR2-1227R Recombinant Rat CCR2 Protein Mammalian Cell His
    Rhesus Monkey CCR2-705R Recombinant Rhesus Monkey CCR2 Protein, His-tagged E. coli His
    Chicken CCR2-3494C Recombinant Chicken CCR2 Mammalian Cell His
    Kit-1150 CCR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1637 CHO-K1 CCR2 Bioassay Kit N/A
    Kit-1638 CCR2 Total GPCR Internalization Assay Kit N/A

    ccr2 involved in several pathways and played different roles in them. We selected most pathways ccr2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ccr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    ccr2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ccr2 itself. We selected most functions ccr2 had, and list some proteins which have the same functions with ccr2. You can find most of the proteins on our site.

    Function Related Protein

    ccr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccr2.

    Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
    Srivastava, K; Hu, J; et al. Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth. CANCER CELL 26:880-895(2014).

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