Recombinant Human CCR2 Protein
Cat.No. : | CCR2-135H |
Product Overview : | Recombinant Human CCR2 was expressed in Wheat Germ. Liposomes. |
- Specification
- Gene Information
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Description : | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. |
Source : | Wheat Germ |
Species : | Human |
Form : | 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Molecular Mass : | 41.2 kDa |
AA Sequence : | MLSTSRSRFIRNTNESGEEVTTFFD YDYGAPCHKFDVKQIGAQLLPPLYS LVFIFGFVGNMLVVLILINCKKLKC LTDIYLLNLAISDLLFLITLPLWAH SAANEWVFGNAMCKLFTGLYHIGYF GGIFFIILLTIDRYLAIVHAVFALK ARTVTFGVVTSVITWLVAVFASVPG IIFTKCQKEDSVYVCGPYFPRGWNN FHTIMRNILGLVLPLLIMVICYSGI LKTLLRCRNEKKRHRAVRVIFTIMI VYFLFWTPYNIVILLNTFQEFFGLS NCESTSQLDQATQVTETLGMTHCCI NPIIYAFVGEKFRSLFHIALGCRIA PLQKPVCGGPGVRPGKNVKVTTQGL LDGRGKGKSIGRAPEASLQDKEGA |
Applications : | Antibody Production; Functional Study; Compound Screening |
Notes : | Best use within three months from the date of receipt of this protein. Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | CCR2 C-C motif chemokine receptor 2 [ Homo sapiens ] |
Official Symbol : | CCR2 |
Synonyms : | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; MCP-1 receptor; chemokine (C-C motif) receptor 2; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor |
Gene ID : | 729230 |
mRNA Refseq : | NM_001123041 |
Protein Refseq : | NP_001116513 |
MIM : | 601267 |
UniProt ID : | P41597 |
Products Types
◆ Recombinant Protein | ||
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CCR2-705R | Recombinant Rhesus Monkey CCR2 Protein, His-tagged | +Inquiry |
CCR2-0689H | Recombinant Human CCR2 Protein, GST-Tagged | +Inquiry |
CCR2-885R | Recombinant Rat CCR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR2-3015M | Recombinant Mouse CCR2 protein, hFc-tagged | +Inquiry |
◆ Lysates | ||
CCR2-7696HCL | Recombinant Human CCR2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1150 | CCR2 CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1638 | CCR2 Total GPCR Internalization Assay Kit | +Inquiry |
Kit-1637 | CHO-K1 CCR2 Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAntagonists of multiple CCR2 proteins have been developed to inhibit the binding of CCR2 to its ligand CCL2, thereby regulating the inflammatory response and migration of immune cells.
CCR2 protein plays an important role in the field of immune inflammation, and studying the function and regulatory mechanism of CCR2 protein will help the development of new drugs, for example, antagonists targeting CCR2 protein may be applied to the treatment of inflammatory diseases.
The CCR2 protein plays an important role in the migration and activation of macrophages and may therefore be involved in the initiation and progression of infectious diseases.
There are no specific diagnostic methods for the CCR2 protein, but the CCR2 protein could be a potential candidate for inflammatory markers.
By binding to its ligand CCL2, CCR2 protein regulates the release of inflammatory mediators, the migration of immune cells, and the occurrence of inflammatory responses.
CCR2 protein plays an important role in the activation and migration of immune cells, so it can be used in immune vaccine design to promote immune cell infiltration and antigen presentation.
Customer Reviews (3)
Write a reviewThis reproducibility of CCR2 was very good, showing good production process and quality control.
I appreciate the attention paid to product quality by the producers of CCR2, and their product is very stable, which makes our experiments smoother.
The bands of CCR2 in Western blot were regular in shape and showed good quality.
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