CHUK

  • Official Full Name

    conserved helix-loop-helix ubiquitous kinase

  • Synonyms

    CHUK; conserved helix-loop-helix ubiquitous kinase; TCF16; inhibitor of nuclear factor kappa-B kinase subunit alpha; IkBKA; IKK alpha; IKK1; IKKA; NFKBIKA; TCF-16; IKK-a kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha; IKBKA; IKK-alpha; nhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.;

  • Recombinant Proteins
  • Chicken
  • Human
  • Zebrafish
  • E.coli
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHUK-27562TH Recombinant Human CHUK Sf9 Insect Cell N/A
Human CHUK-1004H Recombinant Human Conserved Helix-Loop-Helix Ubiquitous Kinase, GST-tagged Sf9 Insect Cell GST
Human CHUK-52H Recombinant Human CHUK protein, Flag-tagged, Biotinylated Insect Cell Flag
Human CHUK-1351H Recombinant Human CHUK Protein, GST-tagged Wheat Germ GST
Human CHUK-675H Recombinant Human CHUK, His-tagged Insect Cell His
Human CHUK-5129H Active Recombinant Human CHUK Protein, GST-tagged Insect Cell GST
Human CHUK-3943H Recombinant Human CHUK protein, His-tagged E.coli His
Human CHUK-8633HF Active Recombinant Full Length Human CHUK Protein, DDK-tagged, Biotinylated Insect (sf21) DDK
Human CHUK-7671HF Active Recombinant Full Length Human CHUK Protein, DDK-tagged, Biotinylated Insect (sf21) DDK
Human CHUK-3422HF Active Recombinant Full Length Human CHUK Protein, GST-tagged Insect (sf21) GST
Zebrafish CHUK-10645Z Recombinant Zebrafish CHUK Mammalian Cell His
Chicken CHUK-2119C Recombinant Chicken CHUK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHUK Related Research Area

CHUK involved in several pathways and played different roles in them. We selected most pathways CHUK participated on our site, such as AGE/RAGE pathway, AKT phosphorylates targets in the cytosol, Activated TLR4 signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHUK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayEGFR;CHUK;ATF2;AGER;JUN;MMP13;LGALS3;DDOST;TIRAP
AKT phosphorylates targets in the cytosolCDKN1A;CDKN1B;CHUK;AKT3
Activated TLR4 signallingS100B;DUSP4;TIRAP;DUSP3B;UBE2V1;APPB;MAPKAPK2B;PELI3;MAPK14
Activation of NF-kappaB in B cellsCHUK;MALT1
Acute myeloid leukemiaIKBKG;JUP;PPARD;HRAS;RUNX1;KIT;NRAS;RARA;AKT2
Adaptive Immune SystemSiglece;ERAP1;UBE2L6;ASB6;RACGAP1;AHCYL1;HLA-DQB2;SIGLEC5;UBE2F
Adipocytokine signaling pathwayACSL3;PPARGC1A;LEPA;RXRAA;G6PC3;ADIPOR1B;POMC;AGRP;TRAF2
Alternative NF-kappaB pathway

CHUK has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHUK itself. We selected most functions CHUK had, and list some proteins which have the same functions with CHUK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNOLC1;CUL9;ATP13A1;BMPR2B;LIG4;SMARCAL1;UHMK1;UBA5;MAPK12
IkappaB kinase activityIKBKE;IKBKB;CHUK
protein bindingANKRD45;ACSF2;LINC00482;POLE4;PLD2;KRT20;FAM107A;YEATS4;ARHGEF1
protein heterodimerization activityMYF5;MAPK6;HIST1H2BM;TAF4B;MEF2C;BIRC5;ROPN1B;HIST1H4I;NPM1
protein homodimerization activityFOXP2;VOX;GPD1C;TGFB2;AADAT;TREX1;PLEKHB1;C9orf142;UPK1A
protein kinase activityMAP4K6;PTK2AB;PRKACBA;OXSR1B;COL4A3BP;CAMKV;WNK2;TNNI3K;FASTKD1
scaffold protein bindingNCK2;CHUK;NLGN4X;GRID2;NLRP1;HOMER1;NLGN4Y;PARK7;CAV2

CHUK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHUK here. Most of them are supplied by our site. Hope this information will be useful for your research of CHUK.

IKBKG

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