Recombinant Human CHUK

• Cat.No.: CHUK-27562TH
• Product Overview: Recombinant full length Human IKK alpha with a N terminal proprietary tag; molecular weight 114 kDa including tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Non
• Protein Length: 745 amino acids
• Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
• Molecular Weight: 114.000kDa inclusive of tags
• Tissue specificity: Widely expressed.
• Biological activity: Specific activity is 2.5nm/min/mg
• Form: Liquid
• Purity: Densitometry
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain.
• Publications:
  Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry (2013)

Gene Information

• Gene Name: CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ]
• Official Symbol: CHUK
• Synonyms: CHUK; conserved helix-loop-helix ubiquitous kinase; TCF16; inhibitor of nuclear factor kappa-B kinase subunit alpha; IkBKA; IKK alpha; IKK1; IKKA; NFKBIKA
• Gene ID: 1147
• mRNA Refseq: NM_001278
• Protein Refseq: NP_001269
• MIM: 600664
• Uniprot ID: O15111
• Chromosome Location: 10q24-q25
• Pathway: AKT phosphorylates targets in the cytosol, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem
• Function: ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity