Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

CLEC10A

  • Official Full Name

    C-type lectin domain family 10, member A

  • Overview

    ASGPR/MGL (asialoglycoprotein / macrophage galactose lectin receptor) / CD301 is a Ca2+ dependent type II transmembrane lectin. Immunoprecipitation from DCs using anti-DC-ASGPR Monoclonal Antibody yields a major 40-kDa protein. ASGPR mRNA is observed predominantly in immune tissues (DCs and granulocytes), but not in T, B, or NK cells, or monocytes. ASGPR species are restricted to the CD14- derived DCs obtained from CD34+ progenitors, while absent from the CD1a-derived subset. Accordingly, both monocyte-derived DCs and tonsillar interstitial-type DCs express ASGPR protein, while Langerhans-type cells do not. ASGPR is a feature of immaturity, as its expression is lost upon CD40L activation. In agreement with the presence of tyrosine-based and dileucine motifs in the intracytoplasmic domain, Monoclonal Antibody against DC-ASGPR is rapidly internalized by DCs at 37°C. Finally, intracellular ASGPR is localized in early endosomes, suggesting that the receptor recycles to the cell surface following internalization of ligand. ASGPR/HML is a feature of immature DCs and a subtype of macrophages, and likely important for the specialized antigen-capture function of DCs.
  • Synonyms

    HML; MGL; HML2; CD301; CLECSF13; CLECSF14; C-type lectin domain family 10 member A; macrophage lectin 2 (calcium dependent); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived); CD301 antigen; CLEC10A; C-type lectin superfamily member 14; Macrophage lectin 2; macrophage C-type lectin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus monkey
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLEC10A-308H Recombinant Human CLEC10A protein, His-tagged Mammalian cells His Gln61-His316
Human CLEC10A-1450H Recombinant Human CLEC10A Protein Wheat Germ N/A
Human CLEC10A-1856H Recombinant Human CLEC10A protein, His & T7-tagged E.coli His/T7 Thr71~Met239 (Accession # Q8IUN9)
Human CLEC10A-1451H Recombinant Human CLEC10A Protein, GST-tagged Wheat Germ GST
Human CLEC10A-7302H Recombinant Human CLEC10A, Fc tagged HEK293 Fc Gln61-His292
Human CLEC10A-7800H Recombinant Human CLEC10A, His-tagged HEK293 His
Human CLEC10A-1456HCL Recombinant Human CLEC10A cell lysate Human Cell N/A
Human CLEC10A-348H Recombinant Human CLEC10A protein, Fc-tagged HEK293 human/IgG1/Fc 256
Human CLEC10A-306H Recombinant Human CLEC10A Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CLEC10A-3238H Recombinant Human CLEC10A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CLEC10A-2113HF Recombinant Full Length Human CLEC10A Protein, GST-tagged In Vitro Cell Free System GST 316 amino acids
Human CLEC10A-2112HF Recombinant Full Length Human CLEC10A Protein In Vitro Cell Free System 316 amino acids
Human CLEC10A-2681H Recombinant Human CLEC10A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLEC10A-3684H Recombinant Human CLEC10A protein, His-tagged E.coli His 66 - 316 aa
Human CLEC10A-009H Recombinant Human CLEC10A Protein, His-tagged E.coli His
Human CLEC10A-2705H Recombinant Human CLEC10A protein, His-tagged HEK293 His Gln61-His316
Human CLEC10A-1688H Recombinant Human CLEC10A Protein (Gln61-His316), C-His tagged Mammalian cells C-His Gln61-His316
Human CLEC10A-182H Recombinant Human CLEC10A Protein, Fc-tagged HEK293 Fc 316
Human CLEC10A-2681H-B Recombinant Human CLEC10A Protein Pre-coupled Magnetic Beads HEK293
Human CLEC10A-3904H Recombinant Human CLEC10A Protein (Gln61-Asn292), N-Fc tagged Mammalian cells N-Fc Gln61-Asn292
Human CLEC10A-0935H Recombinant Human CLEC10A Protein (Thr71-Met239), N-His tagged E.coli N-His Thr71-Met239
Mouse Clec10a-307M Active Recombinant Mouse Clec10a, His-tagged Mammalian cells His
Mouse Clec10a-6908M Recombinant Mouse Clec10a protein(Gln58-Ser305), hFc-tagged HEK293 N-hFc Gln58-Ser305
Mouse Clec10a-1857M Recombinant Mouse Clec10a protein, His & T7-tagged E.coli His/T7 Arg69~Asp273 (Accession # P49300)
Mouse Clec10a-6909M Recombinant Mouse Clec10a protein(Gln58-Ser305), His-tagged HEK293 N-His Gln58-Ser305
Mouse CLEC10A-1730MCL Recombinant Mouse CLEC10A cell lysate Human Cell N/A
Mouse Clec10a-1737M Recombinant Mouse Clec10a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Clec10a-1737M-B Recombinant Mouse Clec10a Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey CLEC10A-1698R Recombinant Rhesus Monkey CLEC10A Protein HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLEC10A Related Research Area

CLEC10A involved in several pathways and played different roles in them. We selected most pathways CLEC10A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CLEC10A has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC10A itself. We selected most functions CLEC10A had, and list some proteins which have the same functions with CLEC10A. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingGALNT13;BCAN;MLEC;LGALS9C;OS9;Chil3;GALNT14;SIGLEC12;CLEC1B

CLEC10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC10A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC10A.

sSL2

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CLEC10A protein be targeted for immunotherapy? 03/16/2020

Researchers are exploring the potential of targeting CLEC10A to modulate immune responses against cancer and infectious diseases, with the aim of developing novel immunotherapies.

How does CLEC10A protein interact with the immune system? 03/20/2019

CLEC10A functions as a receptor on immune cells, where it can recognize specific glycan structures on pathogens and tumor cells, leading to immune cell activation and modulation of immune responses.

What are the potential clinical implications of modulating CLEC10A activity? 12/16/2018

Modulating CLEC10A activity could have therapeutic implications for cancer immunotherapy, infectious disease treatment, and potentially other immune-related disorders.

How does CLEC10A protein impact the tumor microenvironment? 07/15/2018

CLEC10A expression on tumor-associated macrophages and dendritic cells can influence the immune response within the tumor microenvironment, potentially impacting tumor growth and metastasis.

Is CLEC10A protein expressed in specific cell types? 02/21/2018

CLEC10A is primarily expressed on dendritic cells and macrophages in the immune system, where it plays a role in antigen presentation and immune regulation.

Customer Reviews (3)

Write a review
Reviews
04/30/2022

    The CLEC10A protein exhibits remarkable performance in Western blotting (WB) experiments.

    01/07/2020

      The versatility and efficacy of CLEC10A in these applications make it an invaluable tool for researchers.

      09/17/2018

        Researchers can rely on CLEC10A to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.

        Ask a Question for All CLEC10A Products

        Required fields are marked with *

        My Review for All CLEC10A Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends