cxcr2 Protein, chemokine (C-X-C motif) receptor 2

cxcr2

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cxcr2

Official Full Name chemokine (C-X-C motif) receptor 2
Background The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Synonyms CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCR2-16H Recombinant Human CXCR2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CXCR2-2097H Recombinant Human CXCR2 protein, His & GST-tagged E.coli His/GST
    Human CXCR2-2179H Recombinant Human CXCR2 Protein, GST-tagged Wheat Germ GST
    Human CXCR2-21HCL Recombinant Human CXCR2 HEK293T cell lysate HEK293T Myc/DDK
    Human CXCR2-22HCL Recombinant Human CXCR2 HEK293T cell lysate HEK293T Myc/DDK
    Human CXCR2-26726TH Recombinant Human CXCR2 Wheat Germ N/A
    Human CXCR2-7163HCL Recombinant Human CXCR2 293 Cell Lysate HEK293 N/A
    Human IL8RB-14213H Recombinant Human IL8RB, GST-tagged E.coli GST
    Mouse CXCR2-4108M Recombinant Mouse CXCR2 Protein Mammalian Cell His
    Rat CXCR2-1693R Recombinant Rat CXCR2 Protein Mammalian Cell His
    Chicken CXCR2-5463C Recombinant Chicken CXCR2 Mammalian Cell His
    Kit-0876 Continuous ITP pyrophosphatase Assay Kit N/A
    Kit-0877 PNP Assay Kit N/A
    Kit-1053 Factor IXa Activity Assay Kit (Fluorometric) N/A
    Kit-1190 cAMP CXCR2 (IL8RB) CHO-K1 GPCR Assay Kit N/A
    Kit-1191 CXCR2 (IL8RB) HEK 293 β-Arrestin GPCR Assay Kit N/A
    Kit-1192 CXCR2 (IL8RB) CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1193 CXCR2 Activated GPCR Internalization Assay Kit N/A

    cxcr2 involved in several pathways and played different roles in them. We selected most pathways cxcr2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNA14; IL22; CCR6; CXCL6; ACVR1; EPOR; CCL22; LTA; PPBP; GM2506
    Chemokine signaling pathway AKT2; SHC4; BCAR1; Ccl21c; CDC42; Ccl9; CCR9; XCR1; VAV2; PRKCB
    Phospholipase D signaling pathway SPHK1; PLCG2; INS1; PTGFR; SHC2; GRM6; AGPAT4; SHC4; Pdgfa&Pdgfb; RRAS2
    Endocytosis CDC42; GRK1; FAM125A; PLD1; CAV2; IGF2R; EHD1B; HSPA1A; WIPF2B; ARF6A
    Epithelial cell signaling in Helicobacter pylori infection MAPK13; ADAM17; JAM2; IKBKB; PLCG1; ATP6V1G1; ATP6V1E1; PTPN11; ATP6V1G3; ATP6V0D2

    cxcr2 has several biochemical functions, for example, C-X-C chemokine receptor activity, interleukin-8 binding, interleukin-8 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcr2 itself. We selected most functions cxcr2 had, and list some proteins which have the same functions with cxcr2. You can find most of the proteins on our site.

    Function Related Protein
    C-X-C chemokine receptor activity CXCR2; CXCR7; CCBP2; CXCR4; CXCR5; CCR9A; CXCR3; CXCR3.1; CXCR6; CXCR4B
    interleukin-8 binding A2M; CXCR1; CXCR2
    interleukin-8 receptor activity CXCR1; CXCR2
    protein binding TIMM8A; NDUFB11; UBE2V1; FNTB; ZNF41; RHOB; POU2F3; THSD4; ZFP932; SETMAR
    signal transducer activity TICAM1; TAS2R118; CALCRLA; OLFR49; FPR-RS3; TMTOPS2B; ADRB2A; GPR186; GPR25; DRD4-RS

    cxcr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcr2.

    CXCL8; GRIA1; fldA; ytpB; argH1; q81ye8_bacan

    Anzai, A; Shimoda, M; et al. Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture. CIRCULATION RESEARCH 116:612-U138(2015).
    Xia, JL; Xu, XJ; et al. The potential of CXCL5 as a target for liver cancer - what do we know so far?. EXPERT OPINION ON THERAPEUTIC TARGETS 19:141-146(2015).

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