CXCR2

  • Official Full Name

    chemokine (C-X-C motif) receptor 2

  • Overview

    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • DYKDDDDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCR2-2179H Recombinant Human CXCR2 Protein, GST-tagged Wheat Germ GST
Human CXCR2-16H Recombinant Human CXCR2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CXCR2-21HCL Recombinant Human CXCR2 HEK293T cell lysate HEK293T Myc/DDK
Human CXCR2-22HCL Recombinant Human CXCR2 HEK293T cell lysate HEK293T Myc/DDK
Human CXCR2-2097H Recombinant Human CXCR2 protein, His & GST-tagged E.coli His/GST Met1~Leu57 (Accession # P25025)
Human CXCR2-2315HF Recombinant Full Length Human CXCR2 Protein, GST-tagged In Vitro Cell Free System GST 360 amino acids
Human CXCR2-1081HFL Recombinant Human CXCR2 protein, His&Flag-tagged HEK293 His&Flag 1-360 aa
Human CXCR2-3110H Recombinant Human CXCR2 protein, His-SUMO-tagged E.coli His-SUMO 1-40aa
Human CXCR2-5491H Recombinant Human CXCR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CXCR2-1932H Active Recombinant Human CXCR2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CXCR2-1218H Recombinant Human CXCR2 Protein (Met1-Leu57), N-GST tagged E.coli N-GST Met1-Leu57
Human CXCR2-106HF Recombinant Full Length Human CXCR2 Protein In Vitro Cell Free System 360 amino acids
Human CXCR2-161H Recombinant Human CXCR2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CXCR2-9488HFL Recombinant Full Length Human CXCR2 protein, Flag-tagged Mamanlian cells Flag
Mouse CXCR2-4108M Recombinant Mouse CXCR2 Protein Mammalian Cell His
Mouse CXCR2-2100M-B Recombinant Mouse CXCR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse CXCR2-2100M Recombinant Mouse CXCR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cxcr2-1314M Recombinant Mouse Cxcr2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-359aa
Mouse Cxcr2-905M Recombinant Mouse Cxcr2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cxcr2-2168M Recombinant Mouse Cxcr2 Protein, His-tagged E.coli N-His Met1-Asp80
Rat CXCR2-1693R Recombinant Rat CXCR2 Protein Mammalian Cell His
Rat CXCR2-1352R Recombinant Rat CXCR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCR2-1352R-B Recombinant Rat CXCR2 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL10022BF Recombinant Full Length Bovine C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Canis lupus familiaris (Dog) (Canis familiaris) RFL21452CF Recombinant Full Length Dog C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-356)
Gorilla gorilla gorilla (Western lowland gorilla) RFL33396GF Recombinant Full Length Gorilla Gorilla Gorilla C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Homo sapiens (Human) RFL26660HF Recombinant Full Length Human C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Macaca mulatta (Rhesus macaque) RFL19654MF Recombinant Full Length Macaca Mulatta C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Mus musculus (Mouse) RFL36469MF Recombinant Full Length Mouse C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Oryctolagus cuniculus (Rabbit) RFL56OF Recombinant Full Length Rabbit C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-358)
Pan troglodytes (Chimpanzee) RFL30431PF Recombinant Full Length Pan Troglodytes C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Rattus norvegicus (Rat) RFL15520RF Recombinant Full Length Rat C-X-C Chemokine Receptor Type 2(Cxcr2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Chicken CXCR2-5463C Recombinant Chicken CXCR2 Mammalian Cell His
Kit-0877 PNP Assay Kit N/A
Kit-0876 Continuous ITP pyrophosphatase Assay Kit N/A
Kit-1192 CXCR2 (IL8RB) CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1191 CXCR2 (IL8RB) HEK 293 β-Arrestin GPCR Assay Kit N/A
Kit-1053 Factor IXa Activity Assay Kit (Fluorometric) N/A
Kit-1193 CXCR2 Activated GPCR Internalization Assay Kit N/A
Kit-1190 cAMP CXCR2 (IL8RB) CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CXCR2 Related Articles
  • CXCR2 Related Gene Family
  • CXCR2 Related Research Area

CXCR2 involved in several pathways and played different roles in them. We selected most pathways CXCR2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIfnlr1;Il23a;TNFSF13B;IFNGR2;TGFB1A;PF4;Ifna15;IL5RA;IFNA5
Chemokine signaling pathwayPRKCZ;CXCL3;CXCL13;PRKACB;SOS1;GNB3;CCL17;RAC1;CCL5
Phospholipase D signaling pathwayPIK3CA;KITLG;PPAP2A;PDGFRA;FCER1G;GRM8;Pdgfa&Pdgfb;TSC2;MAP2K2
EndocytosisGRK1A;CXCR1;VPS28;HLA-A;CDC42L;CDC42;GIT1;VPS37A;RAB11FIP5
Epithelial cell signaling in Helicobacter pylori infectionATP6AP1;RAC1;JAM3;IL-8;MET;ATP6V0C;IKBKB;ADAM17;MAPK12

CXCR2 has several biochemical functions, for example, C-X-C chemokine receptor activity, interleukin-8 binding, interleukin-8 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR2 itself. We selected most functions CXCR2 had, and list some proteins which have the same functions with CXCR2. You can find most of the proteins on our site.

Function Related Protein
C-X-C chemokine receptor activityCXCR6;CXCR4A;CXCR5;CXCR4B;CXCR4;CXCR2;CCBP2;CXCR7;CXCR3.1
interleukin-8 bindingCXCR2;A2M;CXCR1
interleukin-8 receptor activityCXCR1;CXCR2
protein bindingLPAR2;CHCHD1;FAM113B;LCMT2;RAB32;LSM10;TUBA4A;ATP6V1F;BBS1
signal transducer activityAXIN1;VMN1R45;DRD2A;OLFR18;TICAM1;OPN1LW1;VMN1R40;TAAR12E;GNA11A

CXCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR2.

CXCL8; GRIA1; fldA; ytpB; argH1; q81ye8_bacan

Anzai, A; Shimoda, M; et al. Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture. CIRCULATION RESEARCH 116:612-U138(2015).
Xia, JL; Xu, XJ; et al. The potential of CXCL5 as a target for liver cancer - what do we know so far?. EXPERT OPINION ON THERAPEUTIC TARGETS 19:141-146(2015).
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