GFAP

  • Official Full Name

    glial fibrillary acidic protein

  • Overview

    This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
  • Synonyms

    GFAP; glial fibrillary acidic protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Porcine
  • Rat
  • Zebrafish
  • bovine Spinal Cord
  • E.coli
  • HEK293
  • HEK293T
  • human Brain
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Spinal cord
  • Wheat Germ
  • Yeast
  • DYKDDDDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • His|SUMO
  • His|SUMO|Myc
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GFAP-19H Recombinant Human GFAP protein, His-tagged E.coli His
Human GFAP-29017TH Recombinant Human GFAP Wheat Germ N/A
Human GFAP-20H Recombinant Human GFAP protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GFAP-13227H Recombinant Human GFAP, His-tagged E.coli His
Human GFAP-885H Recombinant Human GFAP protein, His & S-tagged E.coli His/S
Human GFAP-5955HCL Recombinant Human GFAP 293 Cell Lysate HEK293 N/A
Human GFAP-01H Recombinant Human GFAP Protein, His-tagged HEK293 His
Human GFAP-188HF Recombinant Full Length Human GFAP Protein In Vitro Cell Free System
Human GFAP-1307H Active Recombinant Human GFAP protein, GST-tagged E.coli GST
Human GFAP-526H Native Human GFAP protein human Brain N/A
Human GFAP-2745H Recombinant Human GFAP Protein (Leu292-Met432), His tagged E.coli His
Human GFAP-5315HF Recombinant Full Length Human GFAP Protein, GST-tagged In Vitro Cell Free System GST
Human GFAP-02H Recombinant Human GFAP Protein, DYKDDDDK-tagged HEK293 DYKDDDDK
Human GFAP-4847H Recombinant Human GFAP Protein, GST-tagged Wheat Germ GST
Human GFAP-03H Recombinant Human GFAP protein, His-tagged E.coli His
Human GFAP-3210H Recombinant Human GFAP protein, His-tagged E.coli His
Human GFAP-2201H Recombinant Human GFAP Protein, His-tagged E.coli N-His
Human GFAP-5627H Recombinant Human GFAP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GFAP-468H Active Recombinant Human GFAP protein, His-tagged E.coli His
Human GFAP-5408HFL Recombinant Full Length Human GFAP protein, Flag-tagged Mamanlian cells Flag
Mouse Gfap-887M Recombinant Mouse Gfap protein, His & GST-tagged E.coli His/GST
Mouse Gfap-886M Recombinant Mouse Gfap protein, His & T7-tagged E.coli His/T7
Mouse Gfap-888M Recombinant Mouse Gfap protein, His & GST-tagged E.coli His/GST
Mouse Gfap-1224M Recombinant Mouse Gfap Protein, His-SUMO-tagged E.coli His/SUMO
Mouse GFAP-6307M Recombinant Mouse GFAP Protein Mammalian Cell His
Mouse GFAP-1399M Recombinant Mouse GFAP Protein (1-430 aa), His-tagged Yeast His
Mouse GFAP-3535M Recombinant Mouse GFAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GFAP-3535M-B Recombinant Mouse GFAP Protein Pre-coupled Magnetic Beads HEK293
Mouse GFAP-1902M Active Recombinant Mouse GFAP protein, His-tagged E.coli His
Mouse Gfap-3191M Recombinant Mouse Gfap Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Gfap-1575M Recombinant Mouse Gfap Protein, His-tagged E.coli N-His
Rat Gfap-889R Recombinant Rat Gfap protein, His-tagged E.coli His
Rat GFAP-2508R Recombinant Rat GFAP Protein Mammalian Cell His
Rat Gfap-890R Recombinant Rat Gfap protein, His & T7-tagged E.coli His/T7
Rat GFAP-2164R Recombinant Rat GFAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GFAP-2164R-B Recombinant Rat GFAP Protein Pre-coupled Magnetic Beads HEK293
Bovine GFAP-171B Native bovine GFAP bovine Spinal Cord N/A
Porcine GFAP-18P Native Porcine GFAP Protein Spinal cord
Zebrafish GFAP-8950Z Recombinant Zebrafish GFAP Mammalian Cell His
Zebrafish GFAP-2237Z Recombinant Zebrafish GFAP Protein (1-444 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GFAP Related Articles
  • GFAP Related Research Area
  • GFAP Related Signal Pathway

GFAP involved in several pathways and played different roles in them. We selected most pathways GFAP participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Jak-STAT signaling pathwayJAK2A;IL2RG;IL22RA2;GHRA;IFNA1;IL11RA2;PIM1;IL13RA2;GRB2

GFAP has several biochemical functions, for example, integrin binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFAP itself. We selected most functions GFAP had, and list some proteins which have the same functions with GFAP. You can find most of the proteins on our site.

Function Related Protein
integrin bindingL1CAM;ADAM22;FCER2;CD9;ACTN4;THBS4;Npnt;ITGA5;TLN1
kinase bindingLDHA;JAKMIP2;PER3;DGKQ;STRADA;DLG4;CAB39;PIP5K1A;TENC1
protein bindingPDLIM2;NUP85;RBMY1A1;PLOD3;FANCG;CTF1;MAP1B;INPP5B;CCDC24
structural constituent of cytoskeletonKRT2;GFAP;ACTL6B;TUBA4A;ARPC1B;KRT15;CCDC6;KRT16;TUBA3E

GFAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFAP here. Most of them are supplied by our site. Hope this information will be useful for your research of GFAP.

SH3YL1; KRT13; PIAS2; MOS; TRIM27; KRT15

Sun, Y; Lehmbecker, A; et al. STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 41:347-370(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the main function of GFAP in the central nervous system? 04/04/2022

GFAP is crucial for maintaining the structure and function of astrocytes in the CNS.

How is GFAP used as a biomarker in neurological studies? 03/12/2022

GFAP is used as a biomarker to assess astrocyte activation and neural damage.

How does GFAP contribute to the structure and support of astrocytes? 01/27/2022

It forms intermediate filaments, providing mechanical support and stability to astrocytes.

What role does GFAP play in the response to brain injury? 12/14/2020

It plays a protective role, participating in the glial scar formation post-injury.

How can dysregulation of GFAP affect neural function? 11/28/2020

Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.

In which conditions is an increase in GFAP levels observed? 05/16/2020

Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.

Are there therapeutic interventions targeting GFAP for neurological disorders? 01/28/2020

Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.

Customer Reviews (3)

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Reviews
05/11/2022

    Fast, efficient customer service.

    12/12/2021

      Product works great in assays.

      07/16/2021

        No problems, satisfied customer.

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