GFAP
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Official Full Name
glial fibrillary acidic protein
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Overview
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] -
Synonyms
GFAP; glial fibrillary acidic protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
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- Human
- Mouse
- Pongo abelii
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- S
- T7
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- N
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- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- GFAP Related Signal Pathway
GFAP involved in several pathways and played different roles in them. We selected most pathways GFAP participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | PIAS4A;Il2;IL7R;Ifnl2;AKT1;STAT4;BCL2;IFNA12;IFNA10 |
GFAP has several biochemical functions, for example, integrin binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFAP itself. We selected most functions GFAP had, and list some proteins which have the same functions with GFAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | ICAM2;THBS4;ANGPTL3;ICAM4;IGF1;FCER2;ACTN1;WISP3;ADAM2 |
| kinase binding | ATF5;LDHB;WWC1;TAX1BP1;HAP1;JAKMIP3;PFKL;STUB1;TNFAIP3 |
| protein binding | ZFP110;SORBS2;MTNR1B;BCL6;WDR12;DDX17;PACSIN3;SETD6;FRMPD1 |
| structural constituent of cytoskeleton | TUBGCP5;CCDC6;ACTB;TUBA7L;ANK1;NEFL;SPTBN2;LOR;CYLC1 |
GFAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFAP here. Most of them are supplied by our site. Hope this information will be useful for your research of GFAP.
SH3YL1; KRT13; PIAS2; MOS; TRIM27; KRT15
Research Area
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Q&As (7)
Ask a questionGFAP is crucial for maintaining the structure and function of astrocytes in the CNS.
GFAP is used as a biomarker to assess astrocyte activation and neural damage.
It forms intermediate filaments, providing mechanical support and stability to astrocytes.
It plays a protective role, participating in the glial scar formation post-injury.
Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.
Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.
Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.
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