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Native Human GFAP protein

Cat.No. : GFAP-526H
Product Overview : Native Human GFAP protein purified from Human Brain.
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  • Gene Information
  • Related Products
Description : This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Source : Human Brain
Species : Human
Form : Lyophilized from urea, sodium phosphate, and sodium bicarbonate.
Molecular Mass : 43,000-49,000
Purity : ≥90% by SDS-PAGE
Notes : Prepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Stability : Following reconstitution, aliquot and freeze (-20 centigrade). Stock solutions are stable for up to 3 months at -20 centigrade.
Storage : Storage at -20 centigrade.
Reconstitution : dH2O (1 mg/ml)
Gene Name : GFAP glial fibrillary acidic protein [ Homo sapiens ]
Official Symbol : GFAP
Synonyms : GFAP; glial fibrillary acidic protein; FLJ45472; intermediate filament protein; FLJ42474;
Gene ID : 2670
mRNA Refseq : NM_001131019
Protein Refseq : NP_001124491
MIM : 137780
UniProt ID : P14136
Chromosome Location : 17q21
Pathway : Nuclear signaling by ERBB4, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by ERBB4, organism-specific biosystem;
Function : integrin binding; structural constituent of cytoskeleton;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the main function of GFAP in the central nervous system? 04/04/2022

GFAP is crucial for maintaining the structure and function of astrocytes in the CNS.

How is GFAP used as a biomarker in neurological studies? 03/12/2022

GFAP is used as a biomarker to assess astrocyte activation and neural damage.

How does GFAP contribute to the structure and support of astrocytes? 01/27/2022

It forms intermediate filaments, providing mechanical support and stability to astrocytes.

What role does GFAP play in the response to brain injury? 12/14/2020

It plays a protective role, participating in the glial scar formation post-injury.

How can dysregulation of GFAP affect neural function? 11/28/2020

Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.

In which conditions is an increase in GFAP levels observed? 05/16/2020

Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.

Are there therapeutic interventions targeting GFAP for neurological disorders? 01/28/2020

Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.

Customer Reviews (3)

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Reviews
05/11/2022

    Fast, efficient customer service.

    12/12/2021

      Product works great in assays.

      07/16/2021

        No problems, satisfied customer.

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